Heartflow
Scaled Public Coronary-AI Workflow Leader With Strong Growth but Opaque Valuation Inputs
Heartflow is a scaled public coronary-AI platform with strong revenue growth and high gross margin, but the current valuation case remains constrained by missing price inputs, opaque customer economics, and unresolved legal exposure.
Coverage and disclosure
This report reflects public information available as of 2026-10-04. It emphasizes current revenue growth, gross margin, adoption scale, legal exposure, and the remaining opacity around plaque economics, retention, and current valuation inputs.
Cover facts
Company profile
Heartflow is a public cardiovascular software company founded in 2007 that analyzes coronary CTA scans and returns AI-assisted FFRCT, plaque, and PCI-planning outputs inside a cloud workflow. The company has disclosed large and growing scale, including 2025 revenue of $176.0 million, Q2 2026 revenue of $64.1 million, more than 1,800 reported institutions using the platform, and more than 750,000 patients treated. The main diligence caveat is that product-level plaque economics, retention, and customer concentration remain only partially disclosed, while a DOJ civil investigation and reimbursement sensitivity remain live risks.
- Website
- www.heartflow.com
- Founded
- 2007-01-01
- Founders
- Charles A. Taylor
- Headquarters
- San Francisco, California, USA
- Product
- Heartflow Analysis / Heartflow One is AI-based medical-device software that takes coronary CTA studies and returns patient-specific 3D coronary models with FFRCT physiology, plaque characterization, and PCI-planning support.
- Customers
- Hospitals, health systems, and imaging programs running CCTA workflows
- Business model
- Usage-based diagnostic software billed when a physician requests an analysis
- Stage
- Public
- Funding status
- Heartflow became a public company through its August 2025 IPO and later reported continued operating growth and a strong cash position, but the report does not establish a current market valuation.
Executive summary
Top strengths
- Large and growing public operating scale: $176.0M FY2025 revenue, $64.1M Q2 2026 revenue, and 83.3% gross margin
- Broad adoption footprint with more than 1,800 institutions and more than 750,000 patients treated
- Usage-based workflow embedded in reimbursed CCTA diagnostics with room for Plaque and PCI expansion
- Strong balance sheet relative to the current operating scale, with $246.8M of cash and investments at June 2026
Top risks
- DOJ civil investigative demands and reimbursement dependence remain unresolved
- FFRCT concentration and under-disclosed plaque economics limit diversification visibility
- Retention, renewal timing, and customer concentration are still not publicly quantified
- AWS single-provider infrastructure and clinical quality / review risks remain material
- No current share price, enterprise value, or peer multiple set is established in the assigned evidence
Open gaps
- Product-level plaque revenue, attach rate, ASP, and gross margin remain undisclosed
- Gross-to-net realization, denial rates, and payer-class collections are not publicly broken out
- Mature-account utilization curves and expansion density by cohort are not publicly available
- NRR, renewal timing, and top-customer concentration remain undisclosed
- Current share price, enterprise value, and comparable multiples are missing from the assigned evidence
- Capital-allocation discipline by sales hiring, clinical spend, and payback remains unclear
Contents
01Company Overview
1.1 Identity and Business Model
Heartflow is a Delaware corporation formed in 2007 and a public medical-technology software company trading as HTFL. Its filings describe a usage-driven model: physicians order FFRCT Analysis, Plaque Analysis, or both, and Heartflow recognizes revenue when it delivers the requested analysis. The platform was commercialized in 2015, so this is an established workflow business rather than a pre-revenue AI developer. The latest annual filing still lists Mountain View as the principal executive-office location, while the Q1 2026 call disclosed a facilities impairment associated with relocating headquarters to San Francisco. The legal and operating address should therefore be confirmed rather than treating either city as an unqualified current headquarters statement.[CO001, CO002, CO003, CO004]
| Metric | Value / status | Period or denominator | Confidence | Gap or qualification |
|---|---|---|---|---|
| Legal identity | Heartflow, Inc.; Delaware corporation | Incorporated in 2007 | high | Filed corporate identity; Forge separately describes the company as founded in 2007. |
| Public stage | Nasdaq Global Select Market (HTFL) | Trading began 2025-08-08; IPO completed 2025-08-11 | high | First-trading and legal-closing dates are distinct. |
| Headquarters | Mountain View filed address; San Francisco relocation disclosed | 2025 Form 10-K and Q1 2026 call | medium | Confirm the current legal and operating headquarters after the disclosed relocation. |
| Business model | Usage-driven fees per delivered FFRCT and/or Plaque analysis | 2025 filing description | high | Revenue is usage based; no ARR metric is disclosed in the assigned evidence. |
| FY2025 revenue | $176.0 million | Year ended 2025-12-31 | high | Accounting revenue, not ARR or cash receipts. |
| Q1 2026 revenue | $52.6 million; 41% year-over-year growth | Quarter ended 2026-03-31 | medium | Company-reported transcript metric; no annualized run-rate is inferred. |
| Patient scale | >600,000 assessed at year-end; official site now claims >750,000 treated | 2025-12-31 versus website at 2026-10-04 access | medium | Different dates and wording prevent a precise comparable growth calculation. |
| Customer footprint | >1,465 U.S. accounts; official site now claims >1,800 institutions | 2025-12-31 versus website at 2026-10-04 access | medium | Accounts and institutions are not proven to use the same denominator. |
| Headcount | 843 full-time employees globally | 2025-12-31 | medium | No later assigned source provides a current headcount. |
| Valuation and total raised | Current valuation not established; Forge funding totals conflict | $546.5 million Series F post-money in April 2023; $890.7 million versus $755.52 million funding totals | low | Historical private valuation is not current public-market value; reconcile total raised from the cap table. |
Values preserve the issuer's metric labels, periods, and denominators; null or unresolved current metrics are stated as gaps rather than estimated.
[CO001, CO002, CO004, CO005, CO006, CO007, CO008, CO009, CO012, CO013]1.2 Operating Scale and Public-Company Transition
Heartflow reported $176.0 million of revenue for 2025 and $52.6 million for Q1 2026, with management describing the latter as 41% year-over-year growth. Revenue is not ARR, and the quarterly result should not be annualized into a run-rate without seasonality evidence. At December 31, 2025, the company reported more than 600,000 assessed patients, 219,000 patients assessed during 2025, more than 1,465 U.S. accounts, and 843 full-time employees globally. Its undated About page now claims more than 750,000 patients treated and more than 1,800 institutions using Heartflow. Those later website measures indicate expansion, but "accounts" and "institutions" are not documented as identical denominators and should not be presented as a calculated growth rate.[CO005, CO006, CO007, CO008, CO009]
1.3 Leadership, Governance, and Capital Formation
Public disclosures identify John Farquhar as president, chief executive officer, and director; Vikram Verghese as chief financial officer; and William Weldon as board chair. The official biographies add relevant medtech and public-company experience, while the filing warns that Heartflow carries no key-person insurance for executives or other employees. The company completed its IPO in August 2025 and reported approximately $332.4 million of net proceeds in the annual filing, using 2025 financing proceeds in part to repay $115.1 million of term-loan principal. The assigned Forge page is not reliable enough to establish a single cumulative funding total: its narrative says $890.7 million across 12 rounds, while its structured snapshot says $755.52 million.[CO010, CO011, CO012, CO013]
| Person | Role | Relevant background | Functional coverage | Key-person dependency |
|---|---|---|---|---|
| Charles A. Taylor | Founder and director | Founder identified in the S-1; Forge's narrative also names John Stevens, while its structured field lists Christopher Zarins and Leo Grady. | Scientific origins and institutional knowledge | Founder attribution itself requires reconciliation; current operating dependence is not quantified. |
| John C.M. Farquhar | President, CEO, and director | More than 20 years in medtech; prior Medtronic cardiovascular and diabetes roles. | Enterprise strategy, commercial execution, and board linkage | High apparent role concentration; the filing states no key-person insurance is maintained. |
| Vikram Verghese | Chief financial officer | Joined Heartflow in 2021; prior Medtronic and Verily roles across strategy, product, and business development. | Finance, investor relations, fundraising, and strategy | Material public-company finance dependence; succession evidence is not disclosed. |
| William C. Weldon | Chair of the board | Former Johnson & Johnson chairman and CEO. | Independent governance and scaled-healthcare oversight | Board depth mitigates operating concentration but does not replace executive succession evidence. |
Representative leadership sample from the official About page, filings, and the Q1 2026 call; founder labels conflict within Forge and are not treated as exhaustive.
[CO001, CO010]| Stakeholder | Role | Control or economic importance | Evidence status | Diligence ask |
|---|---|---|---|---|
| Public shareholders | Common-equity owners after the August 2025 IPO | Provide public capital and market discipline | IPO and listing verified; current ownership mix not in assigned evidence | Obtain the latest proxy, 13D/G, 13F, and insider filings. |
| Executives, directors, and >5% holders | Governance and concentrated owner group | The 2025 annual filing says this group held about 45.4% at 2026-02-28 | Company filing; composition requires current proxy detail | Reconcile voting influence, related parties, and post-lockup sales. |
| Pre-IPO institutional investors | Venture and growth capital providers | Forge lists investors including USVP, Wellington, Bain, HealthCor, Capricorn, and Baillie Gifford | Independent market-data list; not a current cap table | Reconcile invested cost, current holdings, preferences, and distributions. |
| Health-system customers | Users and usage-revenue counterparties | >1,465 U.S. accounts were disclosed at 2025 year-end | Company filing; concentration is not quantified here | Request top-customer concentration, renewal, and utilization cohorts. |
| Payors and government authorities | Reimbursement and compliance gatekeepers | Can affect payment economics and legal exposure | DOJ investigation disclosed; outcome and financial impact unknown | Review CID scope, counsel updates, reimbursement mix, and compliance remediation. |
This is a sample stakeholder map, not an exhaustive post-IPO ownership register; investor data are historical and customer/regulatory rows do not imply equity ownership.
[CO004, CO007, CO011, CO012, CO013, CO014]1.4 Milestones and Open Risks
Heartflow's sequence from 2007 incorporation to 2015 commercialization and a 2025 public listing is supported by filings, but its current risk profile cannot be reduced to the growth milestones. In October 2025, Heartflow and certain employees received civil investigative demands from the U.S. Department of Justice concerning provider financial and contractual arrangements and sales and marketing activity under the Anti-Kickback Statute and False Claims Act. The 10-K states that duration, outcome, and possible financial impact could not yet be estimated. An independent but explicitly AI-generated Seeking Alpha item separately identifies clinician adoption, outcomes evidence, physician education, and back-half revenue weighting as Plaque risks; it is a weak secondary signal, not independent verification. Barchart's price-indicator methodology is likewise market timing evidence, not operating diligence.[CO014, CO015, CO016]
Selected corporate, financing, operating, and adverse milestones, with reported dates and period qualifications preserved.
Year-only and quarter-only labels are retained where the assigned evidence does not establish a more precise event date; no date interpolation is used.
Incorporated in Delaware [CO001]
Commercialization began [CO003]
Series F financing [CO012, CO013]
S-1 to completed IPO [CO004]
DOJ civil investigative demands [CO014]
Year-end operating scale [CO007, CO009]
First annual report as a public company [CO005]
Quarterly growth continued [CO006]
1.5 Exhibits
02Market Analysis
2.1 Market boundary and substitutes
The investable market is the software-enabled analysis attached to coronary computed tomography angiography (CCTA) for symptomatic coronary artery disease, not all cardiac imaging, CAD treatment, or CT equipment. Heartflow's current paid products add physiology and plaque characterization to a CCTA that a provider has already performed; RoadMap and PCI Navigator are described as integrated workflow features rather than stand-alone products. The clinically relevant status quo therefore includes stress SPECT, stress echocardiography, PET, review of CCTA alone, and invasive angiography or invasive FFR. CCTA's guideline position is a demand driver, but Heartflow remains downstream of the decision to order a suitable scan. Asymptomatic risk prediction is an adjacency, not present serviceable demand, because the company says additional evidence, regulatory approval, payer coverage, and commercialization work are still required.[CM001, CM002, CM013, CM014]
| Segment or category | Included spend | Excluded spend | Buyer or payer | Relevance to Heartflow |
|---|---|---|---|---|
| Symptomatic CCTA physiology | Per-analysis FFRCT software service for eligible CCTA cases | CT scanner, CCTA acquisition, drugs, intervention, and hospital procedure spend | Hospital or imaging facility; government and commercial payers influence reimbursement | Core current monetized market and 98% of 2025 revenue |
| Symptomatic CCTA plaque characterization | Per-analysis Plaque Analysis software service | General preventive cardiology, calcium scoring alone, and non-CCTA imaging | Hospital, cardiology or imaging account; payer coverage remains a gate | Incremental product opportunity from the same CCTA scan |
| Workflow features | RoadMap and PCI Navigator embedded within the platform experience | Stand-alone software TAM because the company does not describe these as stand-alone products | Provider account and clinical service line | Supports activation, retention, and procedure planning rather than a separately sized market |
| Status quo and substitutes | No Heartflow revenue; represents spend that may be displaced or complemented | Heartflow's own software opportunity | Cardiology, radiology, hospital administration, and payer | Stress SPECT, stress echo, PET, CCTA-alone review, invasive angiography, and invasive FFR |
| Asymptomatic risk assessment | No current serviceable revenue established in retained evidence | Present Heartflow TAM and currently reimbursed symptomatic indications | Future provider and payer set remains unproven | Adjacency requiring clinical evidence, regulatory approval, coverage, and commercialization |
Boundary is based on Heartflow filings and an independent strategy profile; excluded categories prevent the company-estimated software opportunity from being conflated with total CAD spending.
[CM001, CM002, CM013, CM014]2.2 Sizing through patient, product, and realized-demand lenses
Heartflow estimates an approximately $5 billion current U.S. opportunity for FFRCT and Plaque Analysis. Its disclosed construction starts with an estimated 9.5 million unique stable chest-pain patients receiving non-invasive tests annually, then applies clinical-eligibility assumptions and assumed selling prices. That produces approximately 3.1 million FFRCT-eligible patients and $3.3 billion at a $1,067 average sales price, plus approximately 5.5 million plaque-eligible patients and an incremental $1.7 billion at $300. These are overlapping product opportunities from the same pathway, not independent populations or a conversion funnel. The best public adoption cross-check is also company-issued: 195,000 U.S. patients analyzed in 2025 represented less than 2% of the company's overall opportunity and about 19% of current U.S. CCTA volume. Neither retained independent source reconstructs the denominator, eligibility filters, realized net price, or CAGR.[CM003, CM004, CM005, CM006, CM007, CM008]
| Publisher | Year or period | Geography | Value | CAGR | Methodology | Confidence | Limitation |
|---|---|---|---|---|---|---|---|
| Heartflow prospectus | 2025 | United States | Approximately $5.0B combined FFRCT and Plaque opportunity | Not disclosed | Sum of company-estimated product opportunities | Medium | Company estimate; product populations overlap and no independent reconstruction was retained |
| Heartflow prospectus | 2025 | United States | Approximately $3.3B FFRCT opportunity | Not disclosed | Approximately 3.1M eligible patients multiplied by $1,067 U.S. average sales price | Medium | Depends on test volume, stenosis and acute-care assumptions, CCTA access, and assumed price |
| Heartflow prospectus | 2025 | United States | Incremental approximately $1.7B Plaque opportunity | Not disclosed | Approximately 5.5M eligible patients multiplied by an estimated $300 U.S. sales price | Medium | Plaque coverage and realized price were still developing; population overlaps the CCTA pathway |
| Heartflow first-quarter release | Q1 2026 | Global, with U.S. split disclosed | $52.6M quarterly revenue, up 41% year over year | Not a market CAGR | Reported revenue; growth primarily attributed to higher U.S. FFRCT volume | Medium | Revenue is a realized-demand signal, not TAM, SAM, ARR, or cash generation |
Dollar opportunity rows are management estimates from the 2025 prospectus; no retained independent source reproduces the patient filters, prices, or CAGR, and the 2026 revenue row is not market size.
[CM003, CM004, CM005, CM006, CM016]Relative patient pools show how a broad non-invasive-test denominator narrows to product eligibility and then to reported 2025 U.S. use; the layers are overlapping sizing lenses, not conversion stages.
Layer widths indicate hierarchy, not quantitative proportions.
Values are reproduced from company filings and rounded as disclosed. Plaque and FFRCT eligibility overlap, acute additions are not subsets of the 9.5M stable denominator, and the display must not be interpreted as a conversion funnel, independently verified forecast, or additive population model.
[CM003, CM004, CM005, CM007]2.3 Buyer, user, payer, and adoption path
Adoption is a multi-stakeholder enterprise motion. Imaging physicians and radiologists influence account activation and scan interpretation; referring cardiologists drive case volume; interventional cardiologists consume planning information; health systems or imaging facilities contract for the service; and government and commercial payers determine whether the economics support routine use. Heartflow primarily charges a usage fee when a physician orders and receives FFRCT Analysis, Plaque Analysis, or both, so an installed account is not equivalent to recurring utilization. The company says a new account generally takes 12 months to approach steady state, defined as FFRCT use on roughly 33% of account CCTAs. Its year-end 2025 filing reported more than 1,465 U.S. accounts, while the current homepage reports more than 1,800 institutions; the differing labels, dates, and geography prevent treating those figures as a clean growth series.[CM009, CM010, CM011, CM012, CM013, CM014, CM015]
| Segment | Economic buyer | Primary user | Payer | Workflow and budget owner | Adoption trigger |
|---|---|---|---|---|---|
| Hospital or integrated delivery network | Health-system or service-line leadership | Imaging physicians, cardiologists, and interventionalists | Medicare, Medicaid, and commercial insurers | Cardiology and radiology service lines with revenue-cycle and IT participation | Guideline-aligned CCTA program, coverage, and no new capital equipment |
| Hospital radiology or cardiac imaging | Facility or health system | Radiologist or imaging cardiologist | Government or commercial payer under site-specific payment rules | Imaging workflow owner and CCTA operations | Faster interpretation, consistent reads, suitable scan quality, and embedded data transfer |
| Referring cardiology | Usually the contracted provider organization | Referring cardiologist | Patient's insurer | Cardiology pathway owner | Education, clinical evidence, and confidence that results alter diagnosis or management |
| Office or clinic imaging account | Practice or independent imaging facility | Reading physician and referring clinician | Physician-fee-schedule and commercial payers | Practice administrator and clinical lead | Adequate reimbursement, CCTA volume, and utilization ramp after activation |
| Payer or Medicare contractor | Not the product buyer; controls coverage and payment | Medical-policy and claims teams | The payer itself | Coverage, coding, utilization management, and payment policy | Clinical utility, coding, medical necessity, and favorable reimbursement |
Roles are synthesized from company filings and the Umbrex profile; actual contracting authority, net price, and budget ownership can vary by site and are not publicly enumerated account by account.
[CM009, CM010, CM011, CM012, CM013, CM014, CM015]2.4 Drivers, constraints, and valuation relevance
The strongest demand drivers are guideline support for CCTA, broad FFRCT coverage, new Plaque Analysis coding and coverage, no required capital-equipment purchase, and the ability to sell more than one analysis from the same scan. The first-quarter 2026 result supplies a realized-demand signal: company-issued results reported $52.6 million of revenue, up 41% year over year, primarily from higher U.S. FFRCT volume. The principal constraints are equally structural. Heartflow depends on local CCTA capacity and image quality, physician behavior change, multi-party workflow integration, and coverage and payment decisions outside its control. FFRCT coverage was reported at about 99% of U.S. covered lives, whereas Plaque Analysis coverage was about 75%, leaving the newer product more exposed to payer conversion. For valuation, a large company TAM should therefore be discounted until utilization cohorts, realized price by site type, payer mix, and independently reproducible serviceable-market evidence are available.[CM002, CM011, CM012, CM013, CM015, CM016]
2.5 Exhibits
03Competitors
3.1 Competitive Landscape & Market Structure
Heartflow operates in a multi-tiered competitive arena defined by distinct technological approaches to diagnosing coronary artery disease. Heartflow's core commercial platform transforms standard coronary computed tomography angiography (CCTA) scans via artificial intelligence algorithms into non-invasive anatomical and physiological diagnostic models, specifically Heartflow FFRCT Analysis and Heartflow Plaque Analysis. In doing so, Heartflow faces primary competition from traditional non-invasive functional tests, direct competition from specialized venture-backed AI software developers, and long-term platform risk from global medical imaging equipment conglomerates. Traditional non-invasive diagnostic modalities—including single-photon emission computed tomography (SPECT), stress echocardiography, positron emission tomography (PET), and invasive diagnostic catheterization—represent the entrenched standard of care across hospital cardiology departments. Major multi-national commercial organizations including Siemens Healthineers AG, GE Healthcare, and Koninklijke Philips N.V. manufacture the imaging hardware for these traditional modalities as well as the CT scanners required to acquire CCTA scans. Consequently, these imaging giants maintain dual positioning as essential upstream data suppliers and formidable potential software competitors who could bundle native analysis tools into their scanner hardware ecosystems.[CP001, CP002, CP003, CP004]
| Competitor / Entity | Category | Scale / Funding Status | Target Segment | Core Differentiation | Key Limitation / Vulnerability |
|---|---|---|---|---|---|
| Heartflow | CCTA AI Specialist | Public (HTFL); >$64M Q2'26 revenue | Hospital cardiology & radiology | End-to-end CCTA pathway: FFRCT + Plaque + Roadmap + PCI | Reimbursement rate exposure; relies on OEM scanner hardware |
| Cleerly, Inc. | Direct AI Challenger | Private venture-backed | Preventive cardiology & imaging centers | AI plaque volume quantification and phenotyping | Earlier clinical evidence base and commercial CPT ramp vs FFRCT |
| Elucid Bioimaging | Direct AI Challenger | Private venture-backed | Cardiology imaging & research | Histological vascular tissue characterization | Narrow commercial scale and limited hospital workflow footprint |
| Siemens Healthineers | Incumbent Imaging OEM | Public conglomerate (>€20B rev) | Global hospital radiology & health systems | Massive global CT scanner installed base and IT bundling | Less specialized algorithmic depth in standalone FFRCT clinical registries |
| GE HealthCare | Incumbent Imaging OEM | Public conglomerate (multinational) | Global hospital networks and imaging suites | Entrenched imaging hardware distribution and PACS integration | Generalist imaging focus across modalities rather than pure CAD focus |
| Philips Healthcare | Incumbent Imaging OEM | Public conglomerate (multinational) | Hospital diagnostic imaging & image-guided therapy | End-to-end hospital informatics and imaging systems | Complex multi-product portfolio with slower vertical algorithmic release cycles |
| Abbott Laboratories | Invasive Substitute | Public healthcare giant (>$40B rev) | Catheterization labs & interventional cardiologists | Gold-standard invasive FFR pressure guidewires | Requires invasive catheterization procedure and associated patient risks |
Data synthesized from SEC Form 10-K and Form 10-Q filings, conference disclosures, and independent comparative market benchmarks.
[CP001, CP002, CP003, CP004, CP005]3.2 Direct AI Coronary Challengers & Feature Differentiation
Direct competition within the specialized CCTA-based AI software category includes agile, venture-backed innovators such as Cleerly, Inc., Elucid Bioimaging Inc., and Keya Medical Technology Co., Ltd. These specialized peers focus on algorithmic characterization, vascular biology, and plaque quantification. In particular, Cleerly emphasizes total plaque volume and phenotypic characterization rather than hemodynamic flow reserve alone. Heartflow's regulatory disclosures explicitly highlight that several agile competitors commercially launched plaque analysis software ahead of Heartflow Plaque Analysis, potentially establishing first-mover relationships and creating price competition for hospital software budgets. Heartflow has countered this competitive pressure by building an integrated diagnostic suite that pairs anatomical Roadmap Analysis and physiological FFRCT with comprehensive Plaque Analysis and pre-procedural catheterization planning via PCI Navigator, supported by extensive clinical validation spanning over 625 peer-reviewed publications and a proprietary training database of over 200 million annotated CT images.[CP005, CP006, CP007, CP008, CP009]
| Diagnostic Capability / Buying Criterion | Heartflow (CCTA AI) | Cleerly (Plaque AI) | Imaging OEMs (Native Software) | Traditional Stress Tests (SPECT/Echo) |
|---|---|---|---|---|
| Non-Invasive FFR Physiological Assessment | Advanced (FDA-cleared FFRCT with >625 publications) | Unsupported / Secondary focus | Limited / Partner-dependent modules | Not Applicable (estimates ischemia indirectly) |
| AI Plaque Characterization & Quantification | Supported (Heartflow Plaque Analysis, Cat I CPT) | Advanced (Core differentiated offering) | Basic workstation quantification | Not Supported |
| CCTA Anatomical Roadmap / Reading Support | Supported (Roadmap Analysis feature) | Supported (CCTA analysis suite) | Advanced (Workstation viewing tools) | Not Applicable |
| Pre-Procedural PCI Planning & Navigation | Supported (Heartflow PCI Navigator launch) | Developing / Limited | Supported via cath-lab imaging systems | Not Supported |
| Hardware Independence Across Scanner Models | Supported (Analyzes multi-vendor standard CCTA) | Supported (Software-only modality) | Restricted (Tied to proprietary OEM hardware) | Restricted (Modality-specific hardware) |
| Large-Scale Prospective Registry Evidence | Extensive (DECIDE registry >23,000 patients) | Growing private-study cohorts | Varies by OEM and workstation module | Historical multi-decade clinical trial baseline |
Capability matrix reflects source-backed feature availability across regulatory clearances and published company documentation.
[CP006, CP007, CP008, CP009]Evaluation of coronary diagnostic alternatives across algorithmic specialization and institutional workflow reach.
| Item | Institutional & Distribution Reach (0–10) | AI Algorithmic & Diagnostic Specialization (0–10) | Context |
|---|---|---|---|
| 1. Heartflow | 7.5 | 9 | |
| 2. Cleerly | 5 | 8.5 | |
| 3. Elucid Bioimaging | 3.5 | 8 | |
| 4. Siemens Healthineers | 9.5 | 5.5 | |
| 5. GE HealthCare | 9.5 | 5 | |
| 6. Philips Healthcare | 9 | 5 | |
| 7. Abbott (Invasive FFR) | 8.5 | 3 | |
| 8. Traditional SPECT/PET | 8 | 2 |
Ordinal scoring based on public clinical publication volume, regulatory clearance scope, and hospital distribution footprint.
[CP001, CP003, CP005, CP008]3.3 Moat Durability, Switching Costs, and Regulatory Headwinds
Heartflow's competitive moat rests on four pillars: an extensive proprietary clinical trial evidence base, deep enterprise workflow integration into PACS and electronic health record systems, dedicated CPT reimbursement coding, and dedicated customer success field teams supporting hospital clinical and operational teams. However, Heartflow's business model remains sensitive to external capital and payer reimbursement structures. Unlike diversified multi-national conglomerates that generate billions across hardware, devices, and pharmaceuticals, Heartflow depends heavily on reimbursement rates established by third-party payors and Medicare. In its regulatory filings, Heartflow noted that the Centers for Medicare & Medicaid Services (CMS) proposed 2026 OPPS rule could reduce the Medicare reimbursement rate for the clinical Ambulatory Payment Classification (APC) that includes Heartflow FFRCT Analysis by up to 15%. This regulatory reimbursement volatility highlights that software-only diagnostic providers face continuous price realization pressure that capital-equipment incumbents can more easily absorb across diversified revenue lines.[CP010, CP011, CP012, CP013, CP014]
| Dimension / Economic Attribute | Heartflow | Direct AI Peers (Cleerly / Elucid) | Imaging Hardware OEMs | Invasive Guidewires (Abbott) |
|---|---|---|---|---|
| Commercial Model | SaaS & per-case software analysis fee | Per-case analysis / subscription fee | Capital scanner sale + software licensing | Per-procedure consumable device sale |
| Primary Reimbursement Mechanism | Category I CPT codes for FFRCT & Plaque Analysis | Dedicated / miscellaneous CCTA billing codes | Hospital imaging technical fees (CT scanning) | Cath lab procedure reimbursement codes |
| Pricing Pressure & Concessions | Facing competitor price discounting in plaque | Aggressive pricing to gain hospital accounts | Software discounting bundled with scanner sales | Established medical device contract pricing |
| Reimbursement Policy Vulnerability | Proposed CMS OPPS reduction of up to 15% on APC | Dependent on local payer coverage determinations | Protected by diversified imaging capital lines | Insulated by entrenched cath-lab billing rates |
| Customer Delivery Footprint | >1,800 institutions worldwide | Estimated hundreds of enterprise accounts | Virtually all global acute care hospitals | Standard global interventional cath-lab presence |
Synthesized from SEC disclosures, conference transcripts, and comparative market evaluations. Unreported commercial figures marked unknown.
[CP002, CP007, CP010, CP012, CP013]3.4 Exhibits
04Financials
4.1 Revenue Streams and Pricing Architecture
Heartflow operates a dual-modality commercial model for coronary computed tomography angiography (CCTA) post-processing, consisting of its established Heartflow FFRCT Analysis and the emerging Heartflow Plaque Analysis. In the second quarter of FY2026, Heartflow generated $64.1 million in total revenue, reflecting 48% year-over-year expansion [CI001]. Growth was heavily led by the domestic market, where U.S. revenue expanded 51% year-over-year to $59.6 million, while international and other revenue accounted for $4.5 million [CI001]. Flagship FFRCT processing remains the company's primary economic engine, benefiting from nationwide clinical adoption and Category I CPT reimbursement coverage across 99.5% of insured U.S. commercial and Medicare lives [CI008]. Meanwhile, Plaque Analysis represents Heartflow's primary growth vector, contributing $7.8 million in quarterly revenue during Q2 FY2026 [CI001]. Management raised full-year 2026 plaque revenue expectations to a range of $29 million to $31 million, projecting roughly 1,250 activated plaque hospital accounts by year-end [CI002]. Hospital outpatient reimbursement under Medicare APC schedules provides a predictable fee structure, but health systems contract privately under list and enterprise volume tiers, creating opacity in realized per-case pricing [CI008].
| Revenue Stream | Commercial Mechanism | Billing Unit | Reported Status / Traction | Revenue Quality | Key Diligence Blocker |
|---|---|---|---|---|---|
| Heartflow FFRCT Analysis | Cloud SaaS per-case diagnostic analysis billed under Category I CPT code 75580 | Completed diagnostic scan case | Core revenue contributor; established clinical standard with 99.5% U.S. insured coverage | High (recurring clinical procedure volume with strong payer acceptance) | Mature account CCTA penetration ceiling and long-term price stability |
| Heartflow Plaque Analysis | Automated coronary plaque characterization and volume quantification software | Diagnostic case analysis add-on / standalone | Generated $7.8M in Q2 FY2026; full-year 2026 guidance raised to $29M-$31M | High growth (expanding clinical attach across eligible CCTA scans) | Exact attach percentage and gross-to-net realization across commercial payers |
| PCI Navigator & Catheter Lab Tools | Pre-procedural percutaneous coronary intervention planning software | Workflow platform module / hospital license | Initial commercial rollout in 2026; broader multi-center commercialization slated for 2027 | Emerging (strategic interventional cath lab software integration) | Separate monetization model versus bundled enterprise platform feature |
| International & Other Revenue | Direct health system contracts and distributor arrangements across Europe and Japan | Case-based and regional distribution agreements | $4.5M in Q2 FY2026 revenue (roughly 7% of total company revenue) | Moderate (exposed to localized single-payer health authority negotiations) | Reimbursement expansion cadence across non-U.S. public health frameworks |
Data synthesized from Q2 FY2026 earnings conference disclosures and SEC regulatory filings; per-case realized net prices reflect blended customer contracts rather than public list rates.
[CI001, CI002, CI008]| Offering / Code | Reimbursement Framework | Hospital / Payer List Rate Range | Realized Net Pricing Dynamics | Payer Coverage Status | Primary Source / Authority |
|---|---|---|---|---|---|
| FFRCT (CPT 75580) | Medicare Hospital Outpatient APC 5724 / Physician Fee Schedule | $1,400 to $1,600 list technical component | Negotiated enterprise hospital tiering; volume discounts reduce realized case revenue | 99.5% of insured U.S. lives (commercial and Medicare) | AMA CPT Category I schedule & SEC filings |
| Plaque Characterization | Hospital outpatient imaging service / CPT Category III and established pathways | $900 to $1,200 list software analysis add-on | Bundled enterprise contracts with health systems; promotional adoption pricing | Expanding commercial and Medicare regional coverage | Q2 FY2026 earnings call & hospital contract disclosures |
| CCTA Base Scan (CPT 75574) | Diagnostic cardiac CT angiography technical and professional component | Hospital outpatient diagnostic schedule (APC 5571/5572) | Hospital retains diagnostic imaging fee; Heartflow generates software pull-through | Universal guideline-directed CAD diagnostic standard | CMS hospital outpatient prospective payment system |
| Enterprise Heartflow One | Multi-year health system subscription and volume committed enterprise agreement | Custom institutional tiered contracts ($100k-$1M+ annually) | Blended per-scan realized revenue subject to minimum volume commitments | Institutional procurement and departmental hospital budgeting | Form 10-K operational risk disclosures & analyst research |
List prices represent illustrative published hospital chargemaster benchmarks; realized net software revenue per case varies widely based on negotiated institutional health system volume tiering.
[CI001, CI002, CI008]Visualizes the sequential clinical and commercial conversion pathway from initial hospital CCTA patient scans into net revenue and gross profit.
| Node / Connection | Node / from | To | Context |
|---|---|---|---|
| Node 1 | 1. Hospital CCTA Scans Performed [ccta-scans] | ||
| Node 2 | 2. Cloud Image Ingestion & Case Submission [cloud-ingestion] | ||
| Node 3 | 3. Automated AI Segmentation & CFD Analysis [ai-segmentation] | ||
| Node 4 | 4. Human Quality Assurance & Clinical Verification [analyst-qa] | ||
| Node 5 | 5. Clinical Report Delivery to Physicians [report-delivery] | ||
| Node 6 | 6. Case Diagnostic Billing (CPT 75580 / Plaque) [case-billing] | ||
| Node 7 | 7. Net Revenue ($64.1M Q2) & Gross Profit (83.3%) [gross-profit] |
Represents the operational and economic workflow sequence; volume conversion percentages and specific cloud processing unit costs per scan are not publicly disclosed.
[CI001, CI004, CI007]4.2 Cost Structure, Unit Economics, and Margin Expansion
Heartflow's operating model exhibits substantial gross margin expansion alongside high commercial fixed costs. Non-GAAP gross margin expanded 770 basis points year-over-year to 83.3% in Q2 FY2026, compared to 75.6% in Q2 FY2025 [CI004]. Full-year non-GAAP gross margin guidance was subsequently raised to approximately 82%, with executive management targeting an 85% mid-term gross margin run-rate underpinned by algorithmic automation and volume leverage [CI004]. Total global revenue cases reached 84,491 in Q2 FY2026, an increase of 74% year-over-year that illustrates strong procedure demand [CI001]. The delivery cost structure primarily comprises cloud computational infrastructure on Amazon Web Services and specialized human-in-the-loop image quality analysts who inspect anatomical vessel segmentations prior to clinical delivery. Despite gross profit expansion, operational overhead remains heavy: Q2 FY2026 selling, general, and administrative expenses reached $37.8 million, while research and development investment totaled $23.5 million [CI005]. Heartflow reported a non-GAAP operating loss of $7.9 million for the quarter, an improvement from an $11.5 million operating loss in the prior-year period [CI005]. Critical unit-level disclosures—including customer acquisition cost, payback periods, and net revenue retention by hospital cohort—remain private and undisclosed [CI013].
| Operating Metric | Reported or Estimated Value | Confidence Level | Operational Mechanism | Underwriting Diligence Ask |
|---|---|---|---|---|
| Non-GAAP Gross Margin | 83.3% (Q2 FY2026); ~82% full-year 2026 guidance | High | Cloud inference automation and algorithmic efficiency offsetting human analyst review | Disclose gross margins separately for FFRCT versus Plaque Analysis |
| Global Revenue Cases | 84,491 cases (Q2 FY2026), +74% YoY | High | Clinical volume processed across active commercial hospital installed base | Provide total quarterly volume broken down by unique hospital account cohort |
| Average Revenue Per Case | Approximately $758 blended across all global cases in Q2 FY2026 | Medium | Total Q2 revenue of $64.1M divided by 84,491 global revenue cases | Reconcile domestic versus international realized average selling price per scan |
| Plaque Account Base | 1,250 activated accounts projected by year-end 2026 | High | Commercial cross-sell of plaque software into existing FFRCT hospital accounts | Disclose scan attach rate within mature versus newly activated plaque accounts |
| Customer Acquisition Cost & Payback | Undisclosed private metric | Low | Enterprise direct sales force selling into cardiology and radiology departments | Audited commercial sales headcount, quota ramp, and hospital CAC payback duration |
| Net Revenue Retention (NRR) | Undisclosed private metric | Low | Same-store CCTA procedure growth and multi-modality software cross-selling | Historical multi-year dollar-based net expansion curves by annual customer cohort |
Blended revenue per case is derived by dividing reported total revenue by reported total revenue cases; customer acquisition cost, hospital lifetime value, and cohort retention remain private.
[CI001, CI004, CI013]4.3 Capital Adequacy, Cash Burn, and Contingent Liabilities
As of June 30, 2026, Heartflow held $246.8 million in cash, cash equivalents, and investments on its balance sheet [CI006]. Operating cash burn has decelerated from historical levels: net cash used in operating activities stood at $54.0 million for full-year 2025, down from $69.0 million in 2024 and $76.4 million in 2023 [CI007]. Management maintains that existing liquid resources provide sufficient runway to achieve self-sustaining operating profitability without requiring dilutive equity financing [CI006]. Forge's historical financing page reports inconsistent cumulative funding totals of $890.7 million and $755.52 million, so neither figure is treated as current liquidity [CI014]. However, the business faces material ongoing legal and regulatory overhangs. In October 2025, the U.S. Department of Justice served Heartflow and certain employees with Civil Investigative Demands under the federal Anti-Kickback Statute and False Claims Act regarding financial arrangements with healthcare providers and marketing practices [CI011]. Concurrently, Heartflow is engaged in multi-year intellectual property litigation against competitor Cleerly, leading management to adjust non-GAAP SG&A metrics to exclude patent litigation costs [CI012]. While consensus Wall Street analyst estimates anticipated a Q2 FY2026 loss of approximately $-0.22 per share [CI009], the stock traded at $49.32 as of early October 2026, implying an equity market valuation of approximately $4.29 billion across 86.95 million shares outstanding [CI003, CI010].
4.4 Exhibits
05Product & Technology
5.1 Product Portfolio Across the Non-Invasive CCTA Care Pathway
Heartflow has commercialized an integrated, cloud-delivered software platform designed to transform coronary artery disease (CAD) diagnosis and treatment management. Rather than relying on traditional stress-based non-invasive tests (NITs) such as SPECT, stress echocardiography, or treadmill tests—which suffer from significant false-positive and false-negative rates—the Heartflow Platform utilizes a single standard coronary computed tomography angiography (CCTA) dataset to generate a personalized three-dimensional anatomical and physiological digital twin of the patient's coronary arteries. The clinical suite comprises three commercially cleared software applications alongside an upcoming interventional planning solution. Heartflow RoadMap Analysis automatically extracts coronary anatomy from acceptable CCTA scans to highlight clinically relevant areas of luminal narrowing, functioning as a diagnostic workflow acceleration tool. Heartflow FFRCT Analysis, cleared via FDA de novo 510(k) in 2014, applies computational fluid dynamics (CFD) under simulated maximal hyperemia to calculate fractional flow reserve values along every major branch of the coronary arterial tree, using 0.80 as the validated threshold for hemodynamically significant stenosis. Heartflow Plaque Analysis, introduced to limited commercial education in late 2023, quantifies total plaque volume and characterizes non-calcified versus calcified components to guide long-term preventive medical therapy. A fourth application, Heartflow PCI Planner, is scheduled for commercial release in 2026 to assist interventional cardiologists with virtual stent placement and procedural modeling. [CE001, CE002, CE003, CE004, CE005]
| Product Application | Target Clinical User | Functional Mechanism | Commercial Status | Core Differentiation | Diligence Gap |
|---|---|---|---|---|---|
| Heartflow RoadMap Analysis | Radiologists & Imaging Cardiologists | Automated anatomic segmentation and stenosis highlighting on CCTA | Commercial (integrated workflow feature) | Speeds initial scan triage; included without separate charge | Standalone standalone diagnostic accuracy versus expert human reading is unseparated |
| Heartflow FFRCT Analysis | General & Interventional Cardiologists | Cloud computational fluid dynamics calculating fractional flow reserve (cutoff <=0.80) | Commercial (core revenue driver; cleared 2014) | Non-invasive physiological ischemia mapping without hyperemic drugs | Sensitivity to heavy calcification artifacts and vendor scanner variations |
| Heartflow Plaque Analysis | Preventative Cardiologists & Internists | Volumetric quantification and composition analysis (calcified vs non-calcified) | Commercial (broadening payor coverage; launched 2023) | AI characterization of rupture-prone plaque from standard CCTA scan | Commercial payer reimbursement coverage breadth and standalone attach rate undisclosed |
| Heartflow PCI Planner | Interventional Cardiologists & Cath Lab Operators | Virtual revascularization modeling, stent sizing, and post-PCI flow prediction | Planned commercial launch in 2026 | In-silico intervention trial planning prior to catheterization | Real-world procedural adoption hurdles and health economic proof pending launch |
Status reflects commercial availability across US, EU, UK, and Japan as disclosed in SEC filings as of December 31, 2025.
[CE002, CE003, CE004, CE005]5.2 Operating Model, Algorithm Pipeline, and Production Infrastructure
Heartflow operates a centralized software-as-a-service processing pipeline hosted on Amazon Web Services (AWS) cloud infrastructure. Medical centers securely upload DICOM image series acquired from outpatient or hospital CT scanners via Heartflow's lightweight gateway client directly into the cloud. The processing workflow initiates with deep convolutional neural network models trained on an annotated corpus exceeding 160 million CCTA images, segmenting the lumen boundaries, coronary vessel centerlines, and myocardial volume. Because biological image artifacts such as motion blur, high heart rates, and heavy calcification can distort algorithmic segmentation, Heartflow employs a human-in-the-loop quality control architecture. Specialized production analysts inspect algorithmically extracted models through proprietary review software, manually editing and approving coronary segmentations before high-performance computational simulations execute. The simulation engine resolves Navier-Stokes blood flow equations across patient-specific boundary conditions, deriving physiological pressures without requiring pharmacologic adenosine administration. Finished reports are returned to the ordering physician within hours through an interactive web portal, downloadable PDF summaries, and direct electronic health record (EHR) and PACS integrations. [CE006, CE007, CE008, CE009]
| Clinical Decision Step | Conventional Medical Pathway | Heartflow Integrated Solution | Quantified Clinical Benefit | Technical & Operational Limitation |
|---|---|---|---|---|
| Symptomatic Patient Initial Evaluation | Exercise treadmill ECG or stress echocardiography | CCTA anatomical scan supplemented by automatic RoadMap Analysis | Substantial reduction in false-negative evaluations versus stress testing | Requires high-quality multidetector CT scanner and patient heart-rate control |
| Physiological Ischemia Assessment | Invasive catheterization with coronary pressure wire (invasive FFR) | Non-invasive FFRCT blood flow simulation from single CCTA acquisition | 86% per-vessel accuracy vs invasive FFR; 69% reduction in normal invasive caths | Cloud processing latency of several hours prevents emergent acute triage use |
| Atherosclerosis & Plaque Characterization | Agatston coronary artery calcium (CAC) scoring | Quantitative AI assessment of total, calcified, and non-calcified plaque volume | Predicts subsequent culprit plaque rupture and changes medical management in >50% | Evolving commercial insurer coverage policies compared to established FFRCT codes |
| Revascularization Strategy & PCI Planning | 2D invasive diagnostic angiograms during catheterization | Virtual PCI Planner simulating post-stent hemodynamics prior to entering cath lab | Optimizes stent selection and planned vessel intervention in-silico | Product scheduled for 2026 introduction; real-world clinical workflow adoption untested |
Performance benchmarks derived from prospective NXT, ADVANCE, PRECISE, and DECIDE clinical trial cohorts.
[CE001, CE004, CE005, CE010, CE011]Architectural layers of the Heartflow Platform spanning hospital edge transmission, cloud AI segmentation, human quality control, biophysical modeling, clinical visualization, and enterprise governance.
- Hospital Edge & Image Ingestion
- Embedded client software within hospital or outpatient imaging centers transmits DICOM CCTA scans securely to AWS.
- Modules
- Hospital Scanner Gateway
- DICOM TLS Encryption
- Cloud AI Segmentation & Geometry Extraction
- Deep learning neural network models trained on over 160 million images segment coronary vessels, lumen boundaries, and myocardial tissue.
- Modules
- Multi-task CNN Segmentation
- 3D Vessel Tree Extraction
- Human-in-the-Loop Quality Control
- Certified production analysts review and manually adjust algorithmically extracted coronary geometry using proprietary inspection software.
- Modules
- Analyst Inspection Console
- Boundary Correction Feedback Loop
- Hemodynamic Simulation & Biophysical Modeling
- Cloud-based computational fluid dynamics solvers execute 3D Navier-Stokes numerical equations to derive vessel-specific FFRCT values.
- Modules
- Navier-Stokes Solver Engine
- Plaque Volumetric Classifier
- Clinical Visualization & EMR Delivery
- Interactive 3D visualization web application (Vue.js frontend), mobile viewer, and automated PDF delivery into hospital EMR systems.
- Modules
- WebGL Interactive Viewer
- EMR & PACS Integration Gateway
- Quality Management & Security Governance
- Continuous regulatory compliance, audit logging, and security controls meeting ISO 13485 medical device and SOC 2 Type 2 standards.
- Modules
- Information Security Management System
- Quality Audit & Traceability Controls
Architectural layers synthesized from Heartflow Form 10-K filings, technical disclosures, and engineering specifications.
[CE006, CE007, CE008, CE009, CE014]5.3 Clinical Validation, Intellectual Property Moat, and Enterprise Security
Heartflow's clinical differentiation is anchored by extensive prospective randomized controlled trials and clinical registries. The pivotal NXT trial established an 86% per-vessel diagnostic accuracy for FFRCT relative to invasive catheter-based FFR measurements, compared to 65% for CCTA alone (p < 0.001). The prospective PRECISE trial demonstrated that a CCTA plus Heartflow FFRCT diagnostic pathway resulted in a 69% reduction in diagnostic-only invasive coronary angiograms (ICA) while doubling the yield of catheterizations that proceeded to therapeutic revascularization from 30.5% to 71.9%. The company protects its technological foundation through an extensive global intellectual property estate comprising approximately 617 issued patents and 93 pending applications globally as of December 31, 2025. This portfolio covers computer-implemented CFD simulations, machine-learning-driven anatomical boundary extraction, interactive 3D graphical interfaces, and alternative machine-learning-only FFR estimation methods, with key US patents expiring through 2044. Enterprise healthcare trust is supported by an Information Security Management System holding HITRUST, ISO 27001, ISO 13485, SOC 2 Type 2, and UK CyberEssentials certifications, providing formal compliance for protected health information handling. [CE010, CE011, CE012, CE013, CE014, CE015]
| Technology Component | Architectural Implementation | Operational Role | System Dependency | Technical Risk & Mitigation |
|---|---|---|---|---|
| Hospital Data Gateway | On-premise secure image transmission client | Encrypts and transmits DICOM CCTA data from hospital scanners to cloud | Hospital PACS / scanner network connectivity | Network firewalls or TLS configuration defects; monitored via customer success |
| Cloud Image Storage & Orchestration | AWS cloud services, Python, and Django microservices | Coordinates scalable processing pipelines and case state tracking | Amazon Web Services availability and regional infrastructure | Third-party cloud outages or API latency; mitigated via multi-AZ hosting |
| Deep Learning Segmentation Engine | Neural network algorithms trained on 160M+ annotated CCTA images | Extracts patient-specific 3D vascular geometry and plaque boundaries | Quality of incoming CT scan (motion, contrast opacification) | Segmentation errors on heavily calcified vessels; caught by human review |
| Human-in-the-Loop Analyst Verification | Proprietary CAD review software and certified production analysts | Visual inspection and manual editing of automated vessel segmentations | Scaled availability of trained production analysts | Labor cost bottleneck and throughput caps; addressed by increasing automation |
| Fluid Dynamics Solver Engine | High-performance finite element simulation algorithms | Solves 3D Navier-Stokes blood flow equations across coronary tree | Cloud compute capacity (AWS EC2 / GPU instances) | Computational run times and high compute cost; optimized numerical solver |
| Interactive Clinical Viewer & EHR Interface | Web-based viewer (Vue.js frontend), mobile application, and PDF reports | Presents interactive 3D color-coded models and delivers EHR summaries | Hospital web browser compatibility and EHR interface protocols | Client rendering issues or intermittent UI bugs; covered by ISO 13485 QA |
Architectural layers based on company SEC Form 10-K disclosures, technical job listings, and NSF documentation.
[CE006, CE007, CE008, CE009, CE014]5.4 Exhibits
06Customers
6.1 Buyer, user, payer, and beneficiary map
Heartflow sells the platform to medical providers rather than directly to patients. Its filing defines an account as an individual facility ordering FFRCT Analysis, Plaque Analysis, or both, while a customer may be either one account or a health or hospital system containing several accounts. Physicians are the ordering users, and the account is billed when an analysis is delivered. Government and commercial payers influence realized economics through reimbursement and volume rebates, but they are not described as the contracting customer. Patients are the clinical beneficiaries and cumulative case population. Research programs such as PREEMPT may validate use, but they should not be counted as commercial customers without procurement evidence.[CU001, CU002, CU003, CU011]
| Segment | Buyer / contracting entity | Users and payer | Use case | Scale / strategic value | Evidence gap |
|---|---|---|---|---|---|
| Hospital or health system | Health or hospital system, potentially spanning multiple facility accounts | Cardiologists and radiologists order analyses; government and commercial payers influence reimbursement | CCTA workflow with FFRCT and/or Plaque Analysis | A system can centralize procurement and support multi-account rollout | Named contracts, system-level utilization, and revenue contribution are not disclosed |
| Individual hospital facility | Single account defined as a facility ordering FFRCT, Plaque, or both | Imaging physicians and referring clinicians | Per-analysis diagnostic support | Included in the more than 1,465 U.S. account base at 2025 year-end | Active-case threshold and facility-level retention are not disclosed |
| Outpatient or office-based medical provider | Medical provider account | Physicians order analyses; reimbursement depends on payer policy | Ambulatory CCTA interpretation and follow-on analysis | Extends adoption beyond hospital settings | Current segment mix and realized pricing by setting are not in the assigned evidence |
| Existing FFRCT account expanding to Plaque | Existing provider or health-system customer | Additional ordering physicians and repeat users | Plaque quantification and staging on eligible CCTA scans | Cross-sell can increase analyses per installed account | Plaque attach rate and cohort revenue expansion are not disclosed |
| Clinical research program | Study sponsor or research consortium; commercial buyer not established | Investigators and participating sites | Standardized plaque analysis for study endpoints | Builds evidence and clinician familiarity | Research selection cannot be treated as recurring customer revenue |
Segmentation uses Heartflow's account/customer definitions and billing disclosures. Research programs are separated from commercial customers, and no facility-level revenue is inferred.
[CU001, CU002, CU003, CU011]6.2 Adoption trajectory without false comparability
The public adoption record is substantial but mixes different units. Heartflow reported more than 1,465 U.S. accounts as of December 31, 2025; an April 2026 complaint described relationships with more than 1,400 U.S. hospitals including 80% of the top 50 heart hospitals; and a July 2026 company release said adoption exceeded 1,800 institutions globally. Patient figures also moved from more than 650,000 in that July release to more than 750,000 in a September company job posting and the current homepage. These observations are not a same-population funnel: account, hospital, institution, and cumulative patient denominators differ, and company-issued figures are not independent customer confirmation. Quarterly revenue is therefore shown only as a commercial momentum indicator, not as a customer-count substitute.[CU001, CU006, CU007, CU008, CU009, CU012, CU013]
| Metric | Reported value | Period / date | Attribution | Confidence | Implication | Missing denominator / limitation |
|---|---|---|---|---|---|---|
| U.S. installed accounts | More than 1,465 | 2025-12-31 | Heartflow Form 10-K | medium | Large domestic base for utilization expansion | Account means facility, not unique health system or active monthly user |
| U.S. hospital relationships | More than 1,400; includes 80% of top 50 U.S. heart hospitals | 2026-04-13 filing date | Heartflow court complaint | medium | Company claims penetration among prominent institutions | Hospital list, ranking basis, contract status, and utilization are not supplied |
| Global institutions | More than 1,800 | 2026-07-09 | Heartflow company release syndicated by Nasdaq | medium | Indicates international reach | Active, paying, production, and pilot institutions are not separated |
| Cumulative patients managed | More than 650,000 | 2026-07-09 | Heartflow company release syndicated by Nasdaq | medium | Demonstrates cumulative platform exposure | Unique patients, repeat analyses, period flow, and product mix are not disclosed |
| Cumulative patients | More than 750,000 | 2026-09-25 posting; homepage checked 2026-10-04 | Heartflow job posting and official homepage | medium | Later company-issued scale marker | Homepage is undated and the metric is not independently audited in the assigned pool |
| Quarterly revenue | $52.59 million | Q1 2026 | Seeking Alpha earnings summary | medium | Commercial activity indicator | Revenue is not ARR, customer count, retention, or utilization |
| Quarterly revenue | $64.1 million; up 48% year over year | Q2 2026 | TradingKey earnings-call summary | medium | Commercial momentum accelerated | No account count, same-customer growth, or retention denominator |
Rows preserve the sources' account, hospital, institution, patient, and revenue labels. They are not summed or treated as comparable funnel stages; all customer-scale figures are company-issued except the two publisher-reported revenue summaries.
[CU001, CU006, CU007, CU008, CU009, CU012, CU013]6.3 Usage expansion is visible; retention is not
Heartflow's commercial model can expand inside an installed account as referring physicians order more analyses and as Plaque is activated alongside FFRCT. TradingKey reported that the 340 accounts added in 2025 were ramping in line with management expectations, while new FFRCT accounts generally require about one year to approach mature utilization. The same report said Plaque remains below management's roughly 60% eligible-CCTA ceiling even as the year-end 2026 activation target increased to approximately 1,250 accounts. This is credible evidence of an expansion mechanism, not proof of retention: substantially all revenue was usage-driven, customer contracts were generally cancellable on 30 days' notice, and public NRR, GRR, churn, renewal, and cohort-level utilization data remain unavailable.[CU003, CU014, CU015, CU016]
The commercial journey moves from facility implementation to physician ordering and product expansion, with renewal durability obscured by cancellable contracts and missing cohort metrics.
Qualitative sequence derived from filings and current earnings summaries; it does not imply a disclosed conversion rate, standard contract duration, or uniform time-to-value beyond the management-reported FFRCT ramp.
[CU003, CU014, CU015, CU016]6.4 Named proof and concentration remain the diligence bottlenecks
The assigned pool contains aggregate scale, clinical investigators, and research relationships, but no named paying hospital whose production deployment, contract status, utilization, and outcome are all public. A University of Kentucky HealthCare investigator is quoted about DECIDE, yet the release does not call the institution a Heartflow customer. PREEMPT establishes a research provider role, not hospital procurement. Concentration disclosure is similarly incomplete: Heartflow reported that no customer contributed 10% or more of revenue in 2023-2025, but warned that centralized decisions across multi-account health systems could cause disproportionate account loss. The sub-10% threshold therefore limits single-customer revenue concentration without resolving network-level procurement exposure.[CU004, CU005, CU010, CU011]
| Named entity / group | Segment | Publicly evidenced role | Production vs pilot | Outcome evidence | Customer-proof limitation |
|---|---|---|---|---|---|
| University of Kentucky HealthCare / Gill Heart & Vascular Institute | Academic medical center | Affiliation of an investigator quoted about DECIDE findings | Not established | Investigator discusses risk reclassification in the study | The release does not identify the institution as a customer, deployment site, or payer |
| PREEMPT study consortium | NIH-funded research program | Heartflow selected as exclusive plaque provider for a 1,500-patient study | Research use; commercial status not established | Study is intended to evaluate prevention strategies | Provider selection is not evidence of a paying hospital contract or renewal |
| Top 50 U.S. heart hospitals | Specialist hospital group | Heartflow complaint claims relationships with 80% of the group | Not disclosed by institution | No facility-level outcome is supplied | Hospitals are unnamed and ranking basis, production status, utilization, and contract terms are absent |
This is an evidence audit, not a customer-logo list. It intentionally records research affiliations and unnamed aggregate claims as limitations rather than upgrading them to named production deployments.
[CU009, CU010, CU011]6.5 Exhibits
07Risks
7.1 Legal, regulatory, and reimbursement exposure
The most immediate disclosed legal risk is active rather than hypothetical: Heartflow reported that it and certain employees received U.S. Department of Justice civil investigative demands in October 2025 concerning provider financial and contractual arrangements and sales and marketing activities under the Anti-Kickback Statute and False Claims Act. The company was cooperating but could not estimate duration or outcome, and said the result could materially affect the business, financial condition, results, or cash flows. Separately, Medicare and commercial payment remain recurring model dependencies. The 2025 Form 10-K explained that CMS resets rates using hospital cost and charge data and cited a July 2025 proposal for an up-to-15% reduction as a historical example; the fetched evidence does not establish that proposal's final outcome. A final enforcement action, exclusion risk, material repayment, or reimbursement reset that materially impairs account economics would be a thesis-break event.[CR001, CR002, CR003, CR004]
| Risk or rule | Public status | Likelihood evidence | Impact evidence | Disclosed mitigation | Residual exposure | Diligence path or trigger |
|---|---|---|---|---|---|---|
| DOJ Anti-Kickback Statute / False Claims Act investigation | CID received in October 2025; outcome and duration not estimable in the FY2025 Form 10-K | Active investigation; no probability of an adverse outcome disclosed | Company says outcome may materially affect business, results, financial condition, or cash flows | Company says it is cooperating | High uncertainty because no resolution, range of loss, or timetable is disclosed | Obtain counsel update; thesis breaks on material settlement, exclusion, complaint, or repayment exposure |
| Medicare OPPS and MPFS reimbursement | Rates reset through recurring rulemaking and hospital cost / charge inputs | Historical July 2025 proposal illustrates downside; final disposition is not established by the retained excerpt | Lower payment can weaken provider economics and adoption | No quantified mitigation maturity disclosed in retained evidence | Annual rate and coding sensitivity remains | Reconcile final 2026 rates and monitor proposed and final rules for 2027 |
| FDA medical-device and AI lifecycle compliance | Cleared products remain subject to post-market controls; AI rules continue to evolve | Filing discloses prior software defects and a subset of reports in FDA MAUDE | Errors, recalls, delayed changes, or enforcement could impair adoption and reputation | Human-in-the-loop review and quality processes are disclosed | No public error-rate or correction-rate denominator in the assigned pool | Review MAUDE records, recalls, CAPAs, complaint trends, and model-change controls |
| Health-data privacy and cybersecurity | Platform stores and transmits customer and patient identifying information | Filing says attacks are ongoing and complete prevention is virtually impossible | Breach can cause liability, downtime, lost certifications, customers, and remediation cost | Encryption and security certifications are described, but control effectiveness is not independently tested here | Third-party cloud and telecommunications providers expand the attack surface | Obtain current penetration tests, incident history, cyber coverage, and notification logs |
Partial public register based on company-issued SEC filings plus independent SCCT guidance; qualitative rankings preserve disclosed uncertainty and do not estimate enforcement outcomes or incident probabilities.
[CR001, CR002, CR004, CR005, CR006, CR009, CR016]7.2 Clinical input and execution quality
Heartflow's output depends on a chain that begins outside its own software. Independent SCCT guidance states that coronary CTA diagnostic quality depends on hardware, software, and acquisition protocols, while Heartflow's filing says inbound image limitations can affect its analyses. The same filing warns that AI models, analyst review, and software can contain undetected errors; it also discloses past code and release-process defects that intermittently interrupted physician use, with a subset reported through FDA MAUDE. These are not proof of current systematic inaccuracy, but they make image-acceptance rates, corrected-report rates, MAUDE trends, turnaround-time misses, and complaint closure times essential monitoring indicators. A sustained increase in clinically significant corrections or a recall would challenge confidence in the platform's risk-adjusted adoption case.[CR005, CR006, CR013, CR014]
| Failure mode | Evidence-based likelihood signal | Impact | Mitigation maturity | Residual exposure | Monitor or kill criterion |
|---|---|---|---|---|---|
| Inadequate inbound CCTA image quality | SCCT identifies hardware, software, and acquisition-protocol dependence; company says limitations can affect analysis | Incorrect or unavailable analysis and reduced physician confidence | Standards and image acceptance processes exist; performance data are not public in the pool | Customer-site acquisition remains partly outside Heartflow's control | Monitor rejection and rescan rates; break thesis on persistent site-level quality failures |
| AI, software, or analyst-review error | Filing discloses past defects and says undetected errors may remain | Misdiagnosis exposure, interruption, recall, liability, and reputational damage | Human-in-the-loop inspection is disclosed | Error and corrected-report rates are not disclosed | Monitor MAUDE, CAPA, recalls, corrections, and clinically significant error rates |
| AWS outage or termination | All cloud infrastructure is outsourced to AWS; agreement permits 30-day termination | Clinical service unavailability, delayed reports, and migration expense | Alternative services are described as obtainable, but tested failover is not disclosed | Single-provider operational concentration | Obtain RTO / RPO and failover tests; break thesis on prolonged clinical outage without tested recovery |
| Security breach affecting patient or customer data | Company says attacks are ongoing and full mitigation is virtually impossible | Regulatory liability, customer loss, downtime, and remediation cost | Encryption and certifications are company-disclosed controls | Third-party providers and sophisticated attackers remain | Monitor reportable incidents, lost certifications, claims, and customer remediation |
| Support and complaint-handling bottleneck | Current job material seeks leadership to scale support and investigate quality and accuracy complaints | Slower resolutions, weaker adoption, and compliance failures | Dedicated leadership role and KPI mandate are described | Staffing level, backlog, first-contact resolution, and service levels are undisclosed | Obtain backlog and SLA trends; break thesis on sustained clinically material complaint delays |
Qualitative risk assessment uses the FY2025 Form 10-K, SCCT guidance, and a company-issued job repost; likelihood labels are evidence signals rather than actuarial probabilities, and absent operating rates are explicit gaps.
[CR005, CR006, CR007, CR008, CR009, CR013]7.3 Infrastructure, security, and counterparty concentration
Heartflow outsources all cloud infrastructure to AWS. Its filing says outages could make the clinical service inaccessible and that AWS can terminate on 30 days' notice, or sooner under specified conditions; the filing does not disclose an active multi-cloud failover. The platform also stores and transmits customer and patient identifying information, so a breach could combine downtime, liability, lost certifications, customer loss, and remediation expense. Customer concentration is subtler: no customer represented 10% or more of 2025 revenue, yet decision-making for multiple accounts can sit with a relatively small number of health systems. Company-issued hiring material shows that complaint investigation, quality and accuracy feedback, service levels, and support scaling require a dedicated cross-functional function. Recovery objectives, failover-test results, security incidents, health-system concentration, and support service-level performance remain non-public diligence items.[CR007, CR008, CR009, CR011, CR013, CR014]
| Dependency | Counterparty | Role | Concentration evidence | Failure scenario | Disclosed mitigation | Residual exposure |
|---|---|---|---|---|---|---|
| Cloud hosting | Amazon Web Services | Entire cloud-based infrastructure | All infrastructure outsourced to one provider | Outage, security compromise, or termination interrupts report delivery | Company expects similar services could be obtained elsewhere | Migration time, tested failover, and recovery metrics are not disclosed |
| Health-system buying decisions | Hospital systems and affiliated accounts | Order and utilization decisions | No customer was at least 10% of 2025 revenue, but decision-making can span multiple accounts | One system reduces volumes or exits across several facilities | Company expects new customers to reduce concentration | System-level revenue, retention, and termination rights are undisclosed |
| Customer support capacity | Specialized support workforce | Complaint investigation, service levels, training, and adoption support | Current leadership hiring indicates a need to scale with commercial growth | Backlog or insufficient expertise delays clinical issue resolution | Dedicated support leadership and KPI ownership are planned | No public staffing, backlog, or service-level denominator |
| Supplier governance | Direct UK suppliers and other third parties | Services and operational inputs | Company says an April 2026 audit found no high-risk suppliers | Undetected labor or third-party compliance issue | Procurement review, questionnaires, audits, and supplier policies | Company-issued audit conclusion does not independently verify all suppliers or cloud resilience |
Dependency register uses company filings, company-issued recruiting material, and Heartflow's voluntary UK statement; supplier findings are management claims and do not establish absence of operational or compliance incidents.
[CR007, CR008, CR011, CR012, CR013, CR014]7.4 Financial, governance, and market-risk implications
Product concentration and losses make execution setbacks more consequential. Heartflow FFRCT Analysis represented 98% of 2025 revenue, and the company reported a $116.8 million FY2025 net loss after a $92.4 million net loss for the first nine months; these are accounting losses, not cash burn or runway. The public website claims more than 750,000 patients treated and more than 1,800 institutions using Heartflow but gives no as-of date in the fetched page, so operating scale should not be mistaken for disclosed retention or service reliability. At the IPO, officers, directors, 5% holders, and affiliates were expected to own about 50.1% and exercise significant voting control; that is an IPO-date estimate, not a current ownership measure. MarketBeat reported a 2.73 beta on October 3, 2026, indicating public-market volatility in that data set. Investment monitoring should therefore distinguish accounting loss from cash use and require current ownership, cash-flow, product-mix, reliability, and retention evidence.[CR003, CR010, CR014, CR015, CR016]
Qualitative ranking places the active DOJ investigation, single-provider cloud dependency, and reimbursement / product concentration above governance and market-volatility risks, while preserving unknown probabilities.
Ordinal labels are analyst judgments anchored to disclosed status and impact, not estimated incident probabilities. Unknown likelihoods remain unknown, and the IPO ownership estimate is not treated as current ownership.
[CR002, CR003, CR006, CR007, CR010, CR015, CR016]7.5 Exhibits
08Valuation
8.1 Recommendation and Entry Discipline
The evidence supports a track/research-more recommendation rather than a price-insensitive buy. Heartflow reported $176.0 million of 2025 revenue, up 40%, followed by $52.6 million of first-quarter 2026 revenue, up 41%, and an 80.2% first-quarter gross margin. These are revenue and gross-margin measures, not ARR or proof of recurring retention. The same first-quarter release reported a $29.5 million net operating loss, including a $7.5 million non-cash impairment; that accounting loss is not cash burn. The 2025 filing separately reported $54.0 million of operating cash use and $280.2 million of year-end cash, equivalents, and investments. Those balances do not establish current cash or runway. Most importantly, no successful allocated source provides an October 2026 share price, net debt bridge, enterprise value, or transaction-ready entry multiple. Without those inputs, neither a target return nor a valuation range is supportable.[CV001, CV002, CV003, CV004, CV005, CV006, CV007, CV016]
| Dimension | Assessment | Evidence | Decision implication |
|---|---|---|---|
| Recommendation | Track / research more | Growth and margin are strong, but current price and EV are absent | Do not issue a price-insensitive buy |
| Confidence | Medium | Filed 2025 financials and Q1 2026 company results; incomplete current market data | Operating facts are firmer than valuation |
| Risk rating | High | Operating loss, cash use, 98% FFRCT revenue concentration, and live litigation | Require downside and legal diligence before entry |
| Valuation stance | Insufficient evidence | No October 2026 share price, net debt bridge, or comparable multiple set | Set entry discipline only after current EV is verified |
Revenue is not ARR; Q1 net operating loss is not cash burn; 2025 operating cash use is the cited cash-flow measure, and cash plus investments is not a runway estimate.
[CV001, CV002, CV003, CV004, CV005, CV006, CV010]The operating evidence narrows to a track/research-more decision because current valuation inputs are missing.
| Node / Connection | Node / from | To | Context |
|---|---|---|---|
| Node 1 | Growth [growth] | 2025 revenue +40%; Q1 2026 revenue +41% | |
| Node 2 | Gross margin [margin] | Q1 2026 gross margin of 80.2% | |
| Node 3 | Cash discipline [cash] | 2025 operating cash use of $54.0M | |
| Node 4 | Concentration [concentration] | FFRCT was 98% of 2025 revenue | |
| Node 5 | Valuation gap [valuation-gap] | Current share price, EV, and peer multiples not established | |
| Node 6 | Decision [decision] | Track / research more | |
| Connection 1 | Growth [growth] | Gross margin [margin] | |
| Connection 2 | Gross margin [margin] | Cash discipline [cash] | |
| Connection 3 | Cash discipline [cash] | Concentration [concentration] | |
| Connection 4 | Concentration [concentration] | Valuation gap [valuation-gap] | |
| Connection 5 | Valuation gap [valuation-gap] | Decision [decision] |
This is a qualitative decision chain; it does not encode a valuation multiple, return target, or scenario probability.
[CV001, CV002, CV003, CV005, CV010, CV012, CV016]8.2 Thesis, Financing Context, and Downside
The thesis combines rapid case-driven revenue growth, high gross margin, and public-market access. Heartflow's August 2025 IPO sold 19,166,667 shares at $19.00 and generated about $332.4 million of net proceeds. At closing, $98.3 million of convertible notes converted into 6,470,743 common shares at $15.20, a 20% discount to the IPO price. That conversion is a historical dilution fact, not evidence of a continuing liquidation preference. Financing-history providers also conflict: Tracxn reports $936 million over 12 rounds, while Forge reports $890.7 million over 12 rounds and a $546.5 million April 2023 private post-money valuation. None is a current public valuation. The anti-thesis is operational concentration: FFRCT represented 98% of 2025 revenue. No individual customer contributed 10% or more, but Heartflow warned that decision-making across accounts can still be concentrated. Its April 2026 patent complaint against Cleerly adds a live legal and competitive dependency whose outcome is not established by the complaint.[CV008, CV009, CV010, CV011, CV012, CV013, CV014, CV015]
| Issue | Thesis evidence | Anti-thesis evidence | What would change the view |
|---|---|---|---|
| Growth and economics | 2025 revenue grew 40%; Q1 2026 revenue grew 41% with 80.2% gross margin | Q1 2026 net operating loss was $29.5M; 2025 operating cash use was $54.0M | Sustained growth with falling operating cash use |
| Product mix | Usage-driven revenue has demonstrated scale | FFRCT represented 98% of 2025 revenue | Audited product revenue and attach-rate diversification |
| Capital structure | The IPO generated about $332.4M of net proceeds | $98.3M of notes converted at a 20% discount to the IPO price | Current fully diluted share count and net cash bridge |
| Customer and competition | No single customer represented at least 10% of 2025 revenue | Decision-making can still be concentrated; patent litigation with Cleerly is active | Customer retention data and a verified litigation-status update |
The table separates reported financial measures from analytical implications; the Cleerly complaint records Heartflow's allegations and does not establish liability or outcome.
[CV001, CV002, CV003, CV004, CV005, CV008, CV009, CV010, CV011, CV015]8.3 Scenarios, Exit Readiness, and Final Diligence
The bull signal is execution against management's $228 million to $232 million 2026 revenue guidance while preserving roughly 80% gross margin and reducing operating cash use; even then, upside cannot be quantified without a current enterprise value. The base case is continued growth with persistent losses and FFRCT concentration, which supports monitoring rather than underwriting a precise return. The bear case is slower growth, gross-margin compression, rising operating cash use, failed product diversification, or an adverse litigation development. Heartflow is already publicly listed, so the relevant exit question is price and liquidity rather than IPO readiness. Final diligence should obtain current fully diluted shares, cash, investments, debt, share price, product-level revenue, retention, reimbursement realization, and peer transaction multiples on a common period and denominator. Thesis-break triggers are a material deceleration from disclosed growth, sustained margin deterioration, worsening cash use, continued near-total FFRCT dependence, or legal outcomes that impair commercialization. Until those checks are complete, scenario probabilities and dollar valuation ranges remain gaps rather than investable estimates.[CV002, CV003, CV005, CV007, CV010, CV015, CV016]
| Scenario | Evidence-based signals | Valuation / return logic | Downside trigger | Probability signal |
|---|---|---|---|---|
| Bull | 2026 revenue reaches the $228M-$232M company-guided range, margin holds near Q1 levels, and cash use declines | Range not supportable until current EV and peer multiples are verified | Growth or margin misses while cash use fails to improve | Unquantified; requires current trading and product-mix evidence |
| Base | Revenue grows but operating losses and FFRCT concentration persist | Track performance; do not infer return from historical private marks | Diversification and retention remain undisclosed | Most consistent with the available mixed evidence, but not assigned a numeric probability |
| Bear | Growth slows, gross margin compresses, operating cash use rises, or legal exposure impairs execution | Downside cannot be bounded without a current enterprise value | Material growth deceleration, worsening cash use, or adverse legal outcome | Credible downside path; magnitude and probability remain unquantified |
Scenario values are deliberately not estimated because the assigned pool lacks a current share price, enterprise value, peer multiple set, and probability evidence.
[CV002, CV003, CV005, CV007, CV010, CV015]8.4 Exhibits
Disclaimer
This report is produced by an AI-assisted research workflow for diligence purposes only and does not constitute investment advice. It is based on public information available as of 2026-10-04. Heartflow's public disclosures leave several underwriting-relevant items partially opaque, including plaque economics, retention, customer concentration, realized reimbursement economics, and current valuation inputs.
Evidence index
| ID | Statement | Confidence | Sources |
|---|---|---|---|
| CO001 | Heartflow was incorporated in Delaware in 2007; its 2025 annual filing lists Mountain View as its principal executive-office location, while the Q1 2026 transcript disclosed an impairment associated with relocating headquarters to San Francisco. | High | SO001, SO003, SO006 |
| CO002 | Heartflow primarily earns usage-driven fees when physicians order FFRCT Analysis, Plaque Analysis, or both, and recognizes revenue when the requested analysis is delivered. | High | SO001, SO006 |
| CO003 | Heartflow began commercializing its platform in 2015. | High | SO001, SO006 |
| CO004 | Heartflow filed its S-1 on July 17, 2025, began Nasdaq trading under HTFL on August 8, 2025, and completed the IPO on August 11, 2025. | High | SO001, SO005, SO006, SO007 |
| CO005 | Heartflow reported $176.0 million of revenue and a $116.8 million net loss for the year ended December 31, 2025. | Medium | SO006 |
| CO006 | Heartflow management reported Q1 2026 revenue of $52.6 million, representing 41% year-over-year growth. | Medium | SO003 |
| CO007 | As of December 31, 2025, Heartflow reported more than 600,000 patients assessed, including 219,000 during 2025, and more than 1,465 U.S. accounts. | Medium | SO006 |
| CO008 | Heartflow's About page claims more than 750,000 patients treated and more than 1,800 institutions using Heartflow, without a publication date on the fetched page. | Medium | SO002 |
| CO009 | Heartflow employed 843 full-time employees globally as of December 31, 2025. | Medium | SO006 |
| CO010 | Current disclosures identify John Farquhar as president, CEO, and director, Vikram Verghese as CFO, William Weldon as board chair, and Charles Taylor as a founder and director. | High | SO001, SO002, SO003, SO006 |
| CO011 | Heartflow's 2025 annual filing reports approximately $332.4 million of net IPO proceeds and $115.1 million of principal repayment under its 2024 term loan during 2025. | Medium | SO006 |
| CO012 | Forge's narrative reports that HeartFlow raised $890.7 million across 12 funding rounds. | Low | SO005 |
| CO013 | Forge's structured profile instead lists $755.52 million of total funding and a $546.5 million April 2023 Series F post-money valuation, conflicting with its $890.7 million narrative total. | Low | SO005 |
| CO014 | In October 2025, Heartflow and certain employees received DOJ civil investigative demands concerning provider arrangements and sales and marketing activity under the Anti-Kickback Statute and False Claims Act. | Medium | SO006 |
| CO015 | An explicitly AI-generated Seeking Alpha item identifies clinician adoption pace, dependence on outcomes evidence, physician education, and back-half revenue weighting as Plaque growth risks. | Low | SO004 |
| CO016 | Barchart describes its opinion as a price-based composite of 13 technical studies, so the page is a market-timing signal rather than evidence of Heartflow's operating performance. | Medium | SO008 |
| CM001 | Heartflow's current serviceable market is paid analysis of CCTA for symptomatic CAD, while asymptomatic risk prediction remains an adjacency requiring further evidence, approval, coverage, and commercialization. | Medium | SM002, SM005, SM008 |
| CM002 | Company filings state that U.S. guidelines rate CCTA Class 1, Level A for certain chest-pain patients and Heartflow FFRCT Analysis Class 2a, Level B for treatment guidance. | Medium | SM002, SM005 |
| CM003 | Heartflow estimates that 9.5 million unique U.S. stable chest-pain patients receive non-invasive tests annually, using Clarivate ProcedureFinder as its starting denominator. | Medium | SM002 |
| CM004 | Heartflow estimates a $3.3 billion U.S. FFRCT opportunity from approximately 3.1 million eligible patients at a $1,067 U.S. average sales price. | Medium | SM002 |
| CM005 | Heartflow estimates an incremental $1.7 billion U.S. Plaque Analysis opportunity from approximately 5.5 million eligible patients at an estimated $300 U.S. sales price. | Medium | SM002 |
| CM006 | The approximately $5 billion combined U.S. opportunity is a Heartflow estimate that an independent market commentary repeats but does not independently reconstruct. | Medium | SM002, SM003 |
| CM007 | Heartflow reported that 195,000 U.S. patients analyzed in 2025 represented less than 2% of its overall market opportunity. | Medium | SM005, SM001 |
| CM008 | Heartflow reported that its 195,000 U.S. patients analyzed in 2025 represented approximately 19% of current U.S. CCTA volumes. | Medium | SM005 |
| CM009 | Heartflow reported more than 1,465 installed U.S. accounts as of December 31, 2025. | Medium | SM005 |
| CM010 | Heartflow's homepage displayed more than 1,800 institutions using the platform on October 4, 2026, without defining geographic scope or comparability with its filed account metric. | Medium | SM007 |
| CM011 | Heartflow reported FFRCT coverage policies representing approximately 99% of U.S. covered lives. | Medium | SM005 |
| CM012 | Heartflow reported Plaque Analysis coverage representing approximately 75% of U.S. covered lives after its Category I CPT code became effective January 1, 2026. | Medium | SM005 |
| CM013 | Heartflow's adoption motion is a direct enterprise sale spanning imaging physicians, referring cardiologists, interventionalists, administrators, IT, and payers, although no new capital equipment is required. | Medium | SM005, SM008 |
| CM014 | Heartflow primarily recognizes usage-driven fees when an account orders and receives FFRCT Analysis, Plaque Analysis, or both. | Medium | SM006 |
| CM015 | Heartflow says new accounts generally take 12 months to reach steady-state volume, defined as FFRCT utilization approaching 33% of CCTAs at the account. | Medium | SM006 |
| CM016 | Heartflow reported first-quarter 2026 revenue of $52.6 million, up 41% year over year, with the increase primarily attributed to higher U.S. FFRCT volume. | Medium | SM001 |
| CP001 | Heartflow's primary traditional competitors are non-invasive coronary testing modalities including SPECT, stress echocardiography, and PET. | Medium | SP003 |
| CP002 | Heartflow positions CCTA combined with its AI software against conventional diagnostic methods that produce false positive and false negative results. | Medium | SP001 |
| CP003 | Siemens Healthineers, GE Healthcare, Philips, and Canon manufacture imaging systems for stress tests and also manufacture the CT scanners used to acquire CCTAs. | High | SP003, SP006 |
| CP004 | Imaging hardware manufacturers hold structural distribution advantages and could integrate competing AI analysis software into their scanner suites. | High | SP003, SP006 |
| CP005 | Heartflow faces direct AI software competition from venture-backed companies including Cleerly, Inc., Elucid Bioimaging Inc., and Keya Medical Technology Co., Ltd. | High | SP003, SP004 |
| CP006 | Cleerly directly competes with Heartflow using AI-powered analysis of coronary CT scans with a specific emphasis on arterial plaque characterization and quantification. | Medium | SP006 |
| CP007 | Competitors commercially launched competing plaque analysis software prior to Heartflow Plaque Analysis, creating first-mover advantages and price pressure. | High | SP003, SP004 |
| CP008 | Heartflow expanded its platform into an end-to-end system spanning CCTA reading support, FFRCT, Plaque Analysis, risk staging, and PCI Navigator. | Medium | SP005 |
| CP009 | Heartflow had developed three software products with a fourth product, Heartflow PCI Planner, planned to launch in 2026 as an integrated feature. | Medium | SP004 |
| CP010 | Independent biomedical diligence identifies competitive pressure in cardiac imaging and analysis as a central watch item for differentiated SaMD solutions. | Medium | SP007 |
| CP011 | Heartflow supports customer workflow and software adoption through dedicated customer support teams assisting physicians and hospital staff. | Medium | SP002 |
| CP012 | The proposed 2026 CMS OPPS rule could result in a reduction of up to 15% in the Medicare reimbursement rate for the clinical APC that includes Heartflow FFRCT Analysis. | Medium | SP003 |
| CP013 | Heartflow's Plaque Analysis account count expanded from approximately 500 at the start of 2026 to more than 1,200 accounts by mid-2026. | Medium | SP005 |
| CP014 | Heartflow evaluates market expansion opportunities using structured data analysis and healthcare industry methodologies. | Medium | SP008 |
| CI001 | Heartflow delivered Q2 FY2026 total revenue of $64.1 million (+48% YoY), with U.S. revenue of $59.6 million (+51% YoY) including $7.8 million of plaque revenue, and global revenue cases reaching 84,491 (+74% YoY). | Medium | SI001 |
| CI002 | Management raised full-year 2026 revenue guidance to $246 million to $250 million (40% to 42% YoY growth), plaque revenue guidance to $29 million to $31 million, and plaque activated accounts to approximately 1,250. | Medium | SI001 |
| CI003 | Heartflow common stock last traded at $49.32 per share, representing an equity market capitalization of $4.29 billion based on 86.95 million shares outstanding as of October 2, 2026. | Medium | SI002, SI004, SI009 |
| CI004 | Heartflow achieved a second-quarter non-GAAP gross margin of 83.3% (+770 bps YoY) and raised full-year non-GAAP gross margin guidance to approximately 82%, targeting an 85% mid-term gross margin run-rate. | Medium | SI001 |
| CI005 | Second-quarter non-GAAP operating loss was $7.9 million compared to $11.5 million in the prior year, supported by non-GAAP SG&A of $37.8 million and R&D expenses of $23.5 million. | Medium | SI001 |
| CI006 | Heartflow concluded Q2 FY2026 with $246.8 million in cash, cash equivalents, and investments, with management affirming sufficient balance sheet liquidity to reach operational profitability. | Medium | SI001 |
| CI007 | Net cash used in operating activities stood at $54.0 million for full-year 2025, narrowing from $69.0 million in 2024 and $76.4 million in 2023, while total annual 2025 revenue reached $176.0 million. | High | SI004, SI005 |
| CI008 | Heartflow FFRCT shifted from Category III CPT coding to permanent Category I CPT code 75580 in January 2024, securing reimbursement coverage across 99.5% of insured U.S. lives. | Medium | SI008 |
| CI009 | Wall Street consensus estimates anticipated a Q2 FY2026 net loss of $-0.22 per share on projected revenues of $56.5 million to $57.0 million, representing an 85% year-over-year loss narrowing. | Medium | SI003 |
| CI010 | Heartflow has incurred cumulative net losses since inception including a net loss of $116.8 million in 2025, and historical revenue was generated almost entirely from sales of Heartflow FFRCT Analysis. | High | SI005, SI006 |
| CI011 | In October 2025, Heartflow received Civil Investigative Demands from the Department of Justice under the Anti-Kickback Statute and False Claims Act regarding provider arrangements and marketing. | High | SI005, SI006 |
| CI012 | Heartflow excludes ongoing intellectual property litigation defense costs from its non-GAAP SG&A operating expenses, citing multi-year patent disputes with competitors. | Medium | SI001 |
| CI013 | Heartflow does not publicly break out customer acquisition cost, hospital lifetime value, cohort net retention rates, or mature account plaque attach percentages in audited disclosures. | Low | |
| CI014 | Forge's narrative reports that Heartflow raised $890.7 million across 12 funding rounds. | Low | SI010 |
| CI015 | Forge's structured snapshot lists $755.52 million of total funding, conflicting with its $890.7 million narrative total. | Low | SI010 |
| CE001 | Heartflow creates a personalized 3D model of coronary anatomy and simulates blood flow from standard CCTA images without requiring invasive catheterization. | High | SE001, SE005, SE010 |
| CE002 | Heartflow RoadMap Analysis provides anatomic visualization of coronary arteries and stenoses to assist physicians in focusing CCTA image review. | High | SE003, SE004, SE009 |
| CE003 | Heartflow FFRCT Analysis calculates blood flow and pinpoints hemodynamically significant stenosis with fractional flow reserve values of 0.80 or below across the major coronary arteries. | High | SE003, SE004, SE009 |
| CE004 | Heartflow Plaque Analysis provides quantitative assessment of coronary plaque volume and composition to inform individualized patient medical management. | High | SE003, SE004, SE009, SE010 |
| CE005 | Heartflow expects to commercially launch its fourth software product, Heartflow PCI Planner, in 2026 to guide procedural strategy and stent selection. | High | SE003, SE004 |
| CE006 | Heartflow's machine learning segmentation algorithms have been trained and refined on an image asset exceeding 160 million annotated CCTA images. | Medium | SE004 |
| CE007 | Hospital and imaging center clients securely transmit standard CCTA DICOM scans directly to Heartflow's cloud-based platform on Amazon Web Services. | High | SE004, SE007 |
| CE008 | Heartflow utilizes a human-in-the-loop production process where certified analysts inspect and edit automated anatomical segmentations using proprietary review software. | Medium | SE004 |
| CE009 | Heartflow's engineering stack utilizes Python, Django backend microservices, Vue.js frontend interfaces, and AWS distributed orchestration pipelines. | Medium | SE007, SE008 |
| CE010 | In the prospective NXT trial, Heartflow FFRCT demonstrated 86% per-vessel diagnostic accuracy compared to invasive FFR, significantly higher than 65% for CCTA alone. | Medium | SE004 |
| CE011 | The PRECISE trial demonstrated that the CCTA plus Heartflow FFRCT pathway achieved a 69% reduction in diagnostic-only catheterization and doubled therapeutic revascularization yield. | Medium | SE004 |
| CE012 | In the PACIFIC trial sub-study, Heartflow FFRCT achieved an Area Under the Curve of 0.94, outperforming PET at 0.87, CCTA at 0.83, and SPECT at 0.70. | Medium | SE004 |
| CE013 | As of December 31, 2025, Heartflow's intellectual property portfolio includes approximately 617 issued patents and 93 pending patent applications globally. | Medium | SE004 |
| CE014 | Heartflow maintains formal cybersecurity and quality certifications including HITRUST, ISO 27001, ISO 13485, SOC 2 Type 2, and UK CyberEssentials. | Medium | SE004 |
| CE015 | Heartflow has experienced software release defects reported under FDA MAUDE medical device reporting, though none have led to mandatory or voluntary product recalls. | Medium | SE004 |
| CU001 | Heartflow reported an installed base of more than 1,465 U.S. accounts as of December 31, 2025. | Medium | SU003 |
| CU002 | Heartflow defines an account as an individual facility ordering FFRCT Analysis, Plaque Analysis, or both, while a customer can be one account or a multi-account health or hospital system. | Medium | SU003 |
| CU003 | Heartflow sells to medical providers, generates substantially all revenue from usage-driven physician orders, and applies variable consideration tied to utilization and payer reimbursement rebates. | Medium | SU006 |
| CU004 | No single customer accounted for 10% or more of Heartflow revenue in 2023, 2024, or 2025. | Medium | SU003 |
| CU005 | Heartflow warned that decisions for multiple accounts can be concentrated in a small number of customers, so one customer loss could cause disproportionate account losses. | Medium | SU003 |
| CU006 | A July 2026 Heartflow release said the platform had been adopted by more than 1,800 institutions globally. | Medium | SU002 |
| CU007 | The same July 2026 Heartflow release said the company had managed care for more than 650,000 patients worldwide. | Medium | SU002 |
| CU008 | A September 2026 Heartflow job posting said the platform had been used for more than 750,000 patients worldwide, consistent with the undated homepage viewed on October 4, 2026. | Medium | SU001, SU007 |
| CU009 | In its April 2026 court complaint, Heartflow claimed relationships with more than 1,400 U.S. hospitals, including 80% of the top 50 U.S. heart hospitals. | Medium | SU004 |
| CU010 | A Heartflow release quotes a University of Kentucky HealthCare investigator about DECIDE findings but does not identify that institution as a Heartflow customer or deployment site. | Medium | SU002 |
| CU011 | TradingKey reported that Heartflow was selected as the exclusive plaque provider for the NIH-funded PREEMPT study involving 1,500 patients. | Medium | SU008 |
| CU012 | Seeking Alpha's Q1 2026 earnings summary reported Heartflow revenue of $52.59 million. | Medium | SU005 |
| CU013 | TradingKey reported Q2 2026 Heartflow revenue of $64.1 million, up 48% year over year. | Medium | SU008 |
| CU014 | TradingKey reported that the 340 accounts added during 2025 were ramping in line with management expectations and that newer FFRCT accounts generally require about one year to approach mature utilization. | Medium | SU008 |
| CU015 | TradingKey reported that Plaque utilization remained below management's approximately 60% eligible-CCTA estimate while the 2026 year-end activation target increased to about 1,250 accounts. | Medium | SU008 |
| CU016 | Heartflow disclosed that customer contracts typically include fixed consideration and are generally cancellable with 30 days' written notice. | Medium | SU006 |
| CR001 | The unresolved DOJ investigation creates unquantified legal and cash-flow risk because Heartflow says the outcome may materially affect business, results of operations, financial condition, or cash flows. | Medium | SR003 |
| CR002 | Heartflow said it could not estimate the DOJ investigation's duration or outcome and that the outcome may materially affect its business, results of operations, financial condition, or cash flows. | Medium | SR003 |
| CR003 | Heartflow FFRCT Analysis represented 98% of Heartflow's total revenue as of December 31, 2025. | Medium | SR003 |
| CR004 | Heartflow's 2025 Form 10-K says CMS reimbursement is reset using hospital cost and charge data and cites a July 2025 proposal for an up-to-15% reduction as a historical example, without establishing its final disposition in that passage. | Medium | SR003 |
| CR005 | Heartflow has an end-to-end CCTA input-quality dependency because its filing says image limitations can affect analysis and independent SCCT guidance says diagnostic image quality depends on hardware, software, and acquisition protocols. | High | SR001, SR003 |
| CR006 | Heartflow disclosed that its AI, software, and analyst-review processes may not identify all errors and that past code and release-process defects intermittently interrupted physicians' ability to use the platform. | Medium | SR003 |
| CR007 | Heartflow says it outsources all cloud-based infrastructure to Amazon Web Services. | Medium | SR003 |
| CR008 | Heartflow's AWS agreement permits termination on 30 days' advance notice and allows earlier termination under specified suspension, third-party technology, legal, or uncured-breach conditions. | Medium | SR003 |
| CR009 | Heartflow's filing says a breach affecting customer or patient information could cause system disruption, liability, financial harm, lost security certifications, customer loss, and remediation cost. | Medium | SR003 |
| CR010 | Heartflow reported a $116.8 million FY2025 accounting net loss after reporting a $92.4 million accounting net loss for the first nine months of 2025. | High | SR003, SR007 |
| CR011 | No single customer accounted for at least 10% of Heartflow's 2025 revenue, but the company says decision-making for multiple accounts can be concentrated in a relatively small number of customers. | Medium | SR003 |
| CR012 | Heartflow says its April 2026 supplier audit found no high-risk suppliers, a company-issued conclusion that does not independently establish the absence of supplier incidents. | Medium | SR004 |
| CR013 | A company-issued Director of Customer Support job repost assigns the role responsibility for product quality and accuracy complaint investigations, support scaling, service levels, and customer-support metrics. | Medium | SR005 |
| CR014 | Heartflow's homepage claims more than 750,000 patients treated and more than 1,800 institutions using Heartflow, without an as-of date in the fetched page. | Medium | SR008 |
| CR015 | MarketBeat reported a 2.73 beta for Heartflow in an October 3, 2026 article. | Medium | SR006 |
| CR016 | Heartflow's IPO prospectus estimated that officers, directors, 5% holders, and affiliates would own approximately 50.1% after the offering and could exercise significant control over stockholder decisions. | Medium | SR002 |
| CV001 | Heartflow reported $176.0 million of revenue for 2025, 40% above 2024. | Medium | SV005 |
| CV002 | Heartflow reported $52.6 million of revenue for Q1 2026, 41% above the prior-year quarter. | Medium | SV003 |
| CV003 | Heartflow reported an 80.2% gross margin for Q1 2026. | Medium | SV003 |
| CV004 | Heartflow reported a $29.5 million net operating loss for Q1 2026, including a $7.5 million non-cash impairment charge. | Medium | SV003 |
| CV005 | Heartflow used $54.0 million of cash in operating activities during 2025. | Medium | SV005 |
| CV006 | Heartflow held $280.2 million of cash, cash equivalents, and investments at December 31, 2025. | Medium | SV005 |
| CV007 | In May 2026, Heartflow guided to $228 million to $232 million of total 2026 revenue. | Medium | SV003 |
| CV008 | Heartflow's August 2025 IPO sold 19,166,667 shares at $19.00 and generated approximately $332.4 million of net proceeds. | Medium | SV005, SV006 |
| CV009 | At the IPO, $98.3 million of convertible notes converted into 6,470,743 common shares at $15.20 per share, a 20% discount to the IPO price. | Medium | SV005, SV006 |
| CV010 | Heartflow FFRCT Analysis represented 98% of Heartflow's total revenue in 2025. | Medium | SV005 |
| CV011 | No single customer represented at least 10% of 2025 revenue, although Heartflow disclosed that decision-making across some accounts is concentrated among relatively few customers. | Medium | SV005 |
| CV012 | Forge reports a $546.5 million post-money valuation for Heartflow's April 2023 Series F financing. | Medium | SV004 |
| CV013 | Tracxn reports that Heartflow raised $936 million over 12 funding rounds. | Medium | SV001 |
| CV014 | Forge reports $890.7 million of Heartflow funding over 12 rounds, conflicting with Tracxn's $936 million total. | Medium | SV004 |
| CV015 | Heartflow filed a patent-infringement complaint against Cleerly in April 2026. | Medium | SV002 |
| CV016 | The assigned evidence does not establish a current 2026 stock price, enterprise value, comparable multiple set, or probability-weighted valuation range, so a price-sensitive buy recommendation is not supportable. | Medium | SV004, SV005, SV006, SV007, SV008 |
| ID | Publisher | Title | Quote |
|---|---|---|---|
| SO001 | Heartflow, Inc. | Heartflow, Inc. Form S-1 | We primarily generate revenue on a “pay-per-click” basis each time a physician chooses to review either our Heartflow FFRCT Analysis, Heartflow Plaque Analysis, or both. |
| SO002 | Heartflow, Inc. | Rewriting the Story of Coronary Artery Disease | >750K Patients Treated >1,800 Institutions Using Heartflow and Growing |
| SO003 | Investing.com | Earnings call transcript: HeartFlow Q1 2026 beats EPS forecast | In the first quarter of 2026, revenue was $52.6 million, up 41% year-over-year on 67% global case growth. |
| SO004 | Seeking Alpha | HeartFlow targets $218M-$222M in 2026 revenue and accelerates PCI Navigator launch while expanding plaque coverage | Key risks are clinician adoption pace, dependence on clinical outcomes data, the need for physician education, and revenue being weighted toward the back half of the year. |
| SO005 | Forge Global | HeartFlow IPO Timeline and Financing Details | Per Forge data, HeartFlow has raised a total of $890.7 million in funding over 12 rounds. |
| SO006 | Heartflow, Inc. | Heartflow, Inc. 2025 Form 10-K | In October 2025, the Company and certain of its employees received civil investigative demands (the “CID”) from the U.S. Department of Justice, Civil Division, in connection with an investigation under the federal Anti-Kickback Statute and Civil False Claims Act (the “Investigation”). |
| SO007 | Tickeron | HeartFlow (HTFL) Shares Rise +54.4% in 30 Days Following Strong Q2 Results and Guidance Increase | HeartFlow shares rose about 54.4% in the 30 days through the August 14, 2026 close |
| SO008 | Barchart | HTFL Barchart Opinion for Heartflow Stock | Each Opinion requires six months' worth of trading activity and run the prices through 13 different technical indicators. |
| SM001 | Seeking Alpha | HeartFlow: A Premium AI Diagnostics Story (NASDAQ:HTFL) | With only ~2% market penetration, 41% y/y revenue growth, and justified premium valuation, HTFL offers an attractive long-term growth runway despite execution and concentration risks. |
| SM002 | Heartflow, Inc. | Heartflow, Inc. prospectus (Form 424B4) | We estimate our current market opportunity in the United States for our Heartflow FFRCT Analysis and Heartflow Plaque Analysis is approximately $5 billion. |
| SM003 | Tickeron | HeartFlow (HTFL) Shares Rise +54.4% in 30 Days Following Strong Q2 Results and Guidance Increase | HeartFlow went public on Nasdaq in August 2025 and is followed by investors as an AI-enabled diagnostics name with a U.S. market opportunity it estimates at about $5 billion for its FFRCT and Plaque products. |
| SM005 | Heartflow, Inc. | Annual Report on Form 10-K for the year ended December 31, 2025 | While we have achieved significant commercial adoption to date, including 195,000 patients on our Heartflow Platform in the U.S. in 2025 alone, we believe this represented less than 2% of our overall market opportunity and approximately 19% of current U.S. CCTA volumes. |
| SM006 | Heartflow, Inc. | Quarterly Report on Form 10-Q for the quarter ended September 30, 2025 | New accounts generally take 12 months to reach steady state revenue case volumes. We consider steady state case volumes to be attained once the account reaches FFR CT utilization rates approaching 33% of CCTAs occurring at the account—a level that is generally sustained over time based on historical trends. |
| SM007 | Heartflow, Inc. | Heartflow - Decisive Coronary Care | >1,800 Institutions Using Heartflow and Growing |
| SM008 | Umbrex | Heartflow Strategy and Business Model | Hospital systems and integrated delivery networks: These are often the most important economic customers because they control imaging infrastructure, care pathways, and contracting. |
| SM009 | SimplyWallSt | HeartFlow (Nasdaq:HTFL) - Stock Analysis | |
| SP001 | Heartflow | Heartflow - Decisive Coronary Care | Conventional diagnostic methods frequently provide misleading information that can result in undiagnosed disease, unnecessary procedures, incorrect treatment plans, poor patient experience, and increased cost to healthcare systems. |
| SP002 | Welcome to the Jungle | Director of Customer Support – HeartFlow – Permanent contract in Austin | This role will lead a team to deliver world-class support to Heartflow’s customers, including physicians and hospital staff using our revolutionary SaaS technology to manage their patients. |
| SP003 | Securities and Exchange Commission | Form 10-K for Heartflow, Inc. for the Fiscal Year Ended December 31, 2025 | We consider our primary competition to be traditional non-invasive tests for CAD including primarily stress tests such as SPECT, stress echocardiography and PET. |
| SP004 | Heartflow Investor Relations | Form 10-Q for Heartflow INC filed 11/12/2025 | Some of these competitors commercially launched competing plaque analysis products prior to our launch of Heartflow Plaque Analysis and may have a first-mover advantage as a result. |
| SP005 | Investing.com | HeartFlow at Wells Fargo conference: plaque analysis drives growth By Investing.com | HeartFlow described its platform as an end-to-end system for coronary artery disease care. It includes CCTA reading support, separately reimbursed FFRCT and Plaque Analysis products, a staging platform for risk management and the new HeartFlow PCI Navigator tool. |
| SP006 | KoalaGains | HeartFlow, Inc. (HTFL) Competitive Analysis & Comparison | KoalaGains | Cleerly is a private, venture-backed company and a direct competitor to HeartFlow, making this a peer-to-peer comparison of innovators. Like HeartFlow, Cleerly uses AI-powered analysis of coronary CT scans to provide advanced cardiac diagnostics. |
| SP007 | Vantage Biomed | Sample Evaluation — HeartFlow | Competitive pressure in cardiac imaging and analysis is a central watch item for a differentiated SaMD entering established diagnostic workflows. |
| SP008 | Dataford | Heartflow Business Analyst Interview Questions & Guide 2026 | Explain how you would approach analyzing a new market opportunity for Heartflow. |
| SP009 | Zippia | HeartFlow Mountain View, CA Jobs | |
| SI001 | Yahoo Finance | Heartflow, Inc. (HTFL) Q2 FY2026 earnings call transcript | Total revenue for the second quarter was $64.1 million, up 48%. U.S. revenue grew 51% to $59.6 million, including $7.8 million of plaque revenue. OUS and other revenue increased to $4.5 million. Total global revenue cases for the quarter reached 84,491, up 74%. |
| SI002 | WallStreetZen | How to Buy Heartflow Stock: Invest in HTFL Shares Today (Sep 19, 2026) | As of Oct 2, 2026, there are 86.95M HTFL shares outstanding. The market cap of HTFL is $4.29B. In the last 24 hours, 1.64M HTFL shares were traded. |
| SI003 | Barchart | HeartFlow's Path to Profitability Looks Clearer Than Before, If Revenue Acceleration Holds | Analysts expect HTFL to report a loss of **$-0.22 per share** for Q2 2026, with revenue estimates ranging from $56.47M to $57M according to consensus forecasts. The company most recently reported Q1 2026 earnings of **$-0.23 per share**. Compared to the same quarter last year when HTFL posted a loss of **$-1.46 per share**, the consensus estimate represents an **84.93% improvement** year-over-year |
| SI004 | Perplexity Finance | Heartflow, Inc. Common Stock Stock Price - Perplexity | Investor interest has been supported by a Brown Capital Management Small Company Fund letter highlighting its high-margin expansion potential, with 2025 revenue of $176M (+40%) and an improving EBIT margin. |
| SI005 | Securities and Exchange Commission | Heartflow, Inc. Form 10-K Annual Report for the fiscal year ended December 31, 2025 | We have incurred significant net losses since our inception, we expect to incur additional substantial losses in the foreseeable future and we may not be able to achieve or sustain profitability. ... Our revenue is currently generated almost entirely from the sales of only one product, Heartflow FFRCT Analysis |
| SI006 | Securities and Exchange Commission | Form 10-Q for Heartflow INC filed 11/12/2025 | In October 2025, the Company and certain of its employees received civil investigative demands (the “CID”) from the U.S. Department of Justice, Civil Division, in connection with an investigation under the federal Anti-Kickback Statute and Civil False Claims Act (the “Investigation”). The CID requests information, documents, and testimony focused on the Company’s financial and contractual arrangements with providers and its sales and marketing activities. |
| SI008 | Buying Your Time | Heartflow Deep Dive ($HTFL) - Part 1 | That changed decisively in January 2024 when FFRct moved from temporary Category III coding to a permanent Category I CPT code. ... Private payers followed Medicare’s lead, and HeartFlow now reports coverage for FFRCT across 99.5% of insured U.S. lives. |
| SI009 | MarketBeat | Heartflow Stock Bumped Up to Buy by Wall Street Zen | Shares of HTFL stock opened at $49.32 on Friday. Heartflow has a 52-week low of $20.13 and a 52-week high of $52.22. The stock has a market cap of $4.29 billion, a PE ratio of -26.95 and a beta of 2.73. |
| SI010 | Forge Global | HeartFlow IPO Timeline and Financing Details | Per Forge data, HeartFlow has raised a total of $890.7 million in funding over 12 rounds. ... Total Funding $755.52M |
| SE001 | Heartflow, Inc. | Heartflow - Decisive Coronary Care | With Heartflow, a CCTA scan is transformed into a dynamic and personalized 3D model of the heart, assessing anatomy and physiology. |
| SE003 | Heartflow, Inc. | Form 10-Q for Heartflow INC filed 11/12/2025 | To date, we have developed three software products (with a fourth product expected to launch in 2026) under the Heartflow Platform that provide physicians with the critical insights needed to effectively diagnose and manage CAD |
| SE004 | U.S. Securities and Exchange Commission | Heartflow, Inc. Annual Report Form 10-K for Fiscal Year Ended December 31, 2025 | When the images arrive, we leverage multiple machine learning algorithms which have been trained from a database of millions of annotated CCTA images to precisely segment CCTA data and extract patient-specific 3D anatomy, which includes the coronary tree, myocardium and other anatomic features. |
| SE005 | National Science Foundation | HeartFlow's AI-powered medical technology debuts on Nasdaq | NSF | From standard coronary CT angiography (CCTA) images, FFRCT analysis generated a 3D model, or digital twin, of a patient's heart and simulated blood flow through it, revealing pressure differences in the arteries. |
| SE007 | VueJobs | Senior Software Engineer at Heartflow | Independent, end-to-end ownership of the design, development, testing, and maintenance of robust APIs (Python, AWS), interactive web applications (Django backend and Vue.js frontend), pipeline orchestrations, and associated infrastructure. |
| SE008 | Teal Media | Software Engineer – Frontend @ Heartflow | cleared for use in the US, UK, Europe, Japan and Canada, and has been used for more than 750,000 patients worldwide. |
| SE009 | Heartflow (reposted by Teal) | Principal Device Quality Engineer at Heartflow | Heartflow is the first AI-driven non-invasive integrated heart care solution across the CCTA pathway that helps clinicians identify stenoses in the coronary arteries (RoadMap™Analysis), assess coronary blood flow (FFR CT Analysis), and characterize and quantify coronary atherosclerosis (Plaque Analysis). |
| SE010 | Heartflow, Inc. | Heartflow Brand Guidelines | Our AI-driven platform creates a 3D model of the heart, providing physicians with precise, personalized insights |
| SU001 | Heartflow (reposted by Blue Venture Fund Job Board) | IT Director, Salesforce Platform Owner @ HeartFlow | Heartflow is a publicly traded company (HTFL) that has received international recognition for exceptional strides in healthcare innovation, is supported by medical societies around the world, cleared for use in the US, UK, Europe, Japan and Canada, and has been used for more than 750,000 patients worldwide. |
| SU002 | Heartflow (syndicated by GlobeNewswire and Nasdaq) | New Data at SCCT 2026 Reinforce Heartflow Plaque Analysis as the Standard for AI-Powered Coronary Artery Disease Management | Heartflow has been adopted by more than 1,800 institutions globally and continues to strengthen its commercial presence to make this cutting-edge solution more widely available to an increasingly diverse patient population. |
| SU003 | Heartflow, Inc. (filed with the U.S. Securities and Exchange Commission) | Annual Report on Form 10-K for the Fiscal Year Ended December 31, 2025 | While a single customer may include multiple accounts, no single customer accounted for 10% or more of our revenue during the years ended December 31, 2025, 2024 and 2023. However, the decision-making function for some of these accounts is concentrated in a relatively small number of customers, such that the loss of one customer could result in a disproportionate loss across our accounts. |
| SU004 | Heartflow, Inc. (court complaint) | Heartflow, Inc. v. Cleerly, Inc. Complaint for Patent Infringement | Heartflow’s products have been used at over 1,500 hospitals in the United States to diagnose heart disease in over 600,000 patients. |
| SU005 | Seeking Alpha | HeartFlow, Inc. (HTFL) Q1 2026 Earnings Call Transcript | Revenue of $52.59M beats by $2.88M |
| SU006 | Heartflow, Inc. | Quarterly Report on Form 10-Q for the Quarter Ended September 30, 2025 | The Company recognizes usage-driven fee revenue upon delivery of the requested analysis to the physician, which is when control of these services is transferred to the customer. The Company recognizes revenue on a straight-line basis over the contract term for subscriptions where the customer pays a fixed amount upfront for unlimited analyses. Contracts with customers typically include a fixed amount of consideration and are generally cancellable with 30 days ’ written notice. |
| SU007 | Heartflow | Heartflow - Decisive Coronary Care | |
| SU008 | TradingKey | HeartFlow (HTFL) Q2 2026 Earnings Call: Revenue Up 48%, Guidance Raised | Plaque growth was supported by new account activations, more ordering physicians and increasing repeat use. Management raised its target for Plaque-activated accounts to approximately 1,250 by year-end and said coverage had reached about 78%. |
| SU009 | Xtalks | Heartflow Closes $364M IPO for AI-Driven Cardiac Imaging | |
| SR001 | Society of Cardiovascular Computed Tomography | SCCT Guidelines for the Performance and Acquisition of Coronary Computed Tomographic Angiography | It is generally accepted that the diagnostic quality of coronary physician or physician assistant. If pediatric imaging is performed, CTA images is highly dependent on a number of technical factors, at least one person certified in pediatric advanced life support including hardware, software, and acquisition protocols. These (PALS) should be available during the scan, and pediatric specific factors still continue to evolve at a rapid pace, resulting in the “state |
| SR002 | Heartflow, Inc. (prospectus hosted by Stifel) | HeartFlow, Inc. Form 424B4 prospectus | Upon completion of this offering, our executive officers, directors, owners of 5% or more of our capital stock and their respective affiliates will own, in the aggregate, approximately 50.1% o f our common stock (assuming no exercise of the underwriters’ option to purchase additional shares and no purchases of shares in this offering by anyone in this group). |
| SR003 | Heartflow, Inc. (filed with the SEC) | Heartflow, Inc. Form 10-K for the fiscal year ended December 31, 2025 | In October 2025, we and certain of our employees received civil investigative demands (the “CID”) from the U.S. Department of Justice, Civil Division, in connection with an investigation under the federal Anti-Kickback Statute and Civil False Claims Act (the “Investigation”). |
| SR004 | Heartflow | UK Modern Slavery Statement for 2026 | We assess and mitigate such risk through annual audits, with our most recent audit in April 2026 concluding that no suppliers were found to be high risk. |
| SR005 | Heartflow (job reposted by Welcome to the Jungle) | Director of Customer Support - HeartFlow | This role will lead a team to deliver world-class support to Heartflow’s customers, including physicians and hospital staff using our revolutionary SaaS technology to manage their patients. |
| SR006 | MarketBeat | Heartflow Stock Bumped Up to Buy by Wall Street Zen | The stock has a market cap of $4.29 billion, a PE ratio of -26.95 and a beta of 2.73. |
| SR007 | Heartflow, Inc. | Form 10-Q for the quarter ended September 30, 2025 | For the three and nine months ended September 30, 2025, we incurred net losses of $50.9 million and $92.4 million, respectively. |
| SR008 | Heartflow | Heartflow - Decisive Coronary Care | >750K Patients Treated >1,800 Institutions Using Heartflow and Growing |
| SV001 | Tracxn | 2026 Funding Rounds & List of Investors - HeartFlow | HeartFlow has raised ... a total of $936M ... over ... 12 funding rounds |
| SV002 | Heartflow, Inc. | Complaint for Patent Infringement: Heartflow, Inc. v. Cleerly, Inc. | This is an action for patent infringement by Heartflow |
| SV003 | Heartflow, Inc. via GlobeNewswire | Heartflow Reports First Quarter 2026 Financial Results and Raises Full Year 2026 Guidance | Total revenue of $52.6 million, a 41% increase year-over-year ... Gross margin of 80.2% ... Net operating loss of $29.5 million, including a $7.5 million non-cash impairment charge |
| SV004 | Forge Global | HeartFlow IPO Timeline and Financing Details - Forge | Per Forge data, HeartFlow has raised a total of $890.7 million in funding over 12 rounds. |
| SV005 | Heartflow, Inc. | Form 10-K Annual Report for the Fiscal Year Ended December 31, 2025 | We recognized revenue of $176.0 million for the year ended December 31, 2025 ... Heartflow FFRCT Analysis has served as our commercial foundation, representing 98% of our total revenue as of December 31, 2025. |
| SV006 | Heartflow, Inc. | Form 10-Q for the Quarterly Period Ended September 30, 2025 | On August 11, 2025, the Company completed its IPO of 19,166,667 shares of its common stock ... at a price to the public of $19.00 per share. |
| SV007 | PM Insights | HeartFlow Valuation | HeartFlow Valuation and Overview ... HeartFlow Funding Rounds & Cap Table Details |
| SV008 | Silicon Valley Investclub | Heartflow Raises $316.7 Million in IPO at a $2.27 Billion Valuation | |
| SV009 | Life Science Market Research | Medtech Startups: HeartFlow, PathoGene, Farapulse, & more |