Startup Diligence
Diligence report Cardiovascular imaging AI / Medtech software Public 2026-10-04

Heartflow

Scaled Public Coronary-AI Workflow Leader With Strong Growth but Opaque Valuation Inputs

Heartflow is a scaled public coronary-AI platform with strong revenue growth and high gross margin, but the current valuation case remains constrained by missing price inputs, opaque customer economics, and unresolved legal exposure.

Coverage and disclosure

This report reflects public information available as of 2026-10-04. It emphasizes current revenue growth, gross margin, adoption scale, legal exposure, and the remaining opacity around plaque economics, retention, and current valuation inputs.

Cover facts

FY2025 revenue 01
$176.0M [CO005]
Q2 2026 revenue 02
$64.1M [CI001]
Q2 2026 gross margin 03
83.3% [CI004]
FY2026 revenue guide 04
$246M-$250M [CI002]
Cash + investments (Jun 2026) 05
$246.8M [CI006]
Global adoption 06
1,800+ institutions [CO008]
Patients treated 07
750,000+ [CO008]
Employees 08
843 [CO009]

Company profile

Heartflow is a public cardiovascular software company founded in 2007 that analyzes coronary CTA scans and returns AI-assisted FFRCT, plaque, and PCI-planning outputs inside a cloud workflow. The company has disclosed large and growing scale, including 2025 revenue of $176.0 million, Q2 2026 revenue of $64.1 million, more than 1,800 reported institutions using the platform, and more than 750,000 patients treated. The main diligence caveat is that product-level plaque economics, retention, and customer concentration remain only partially disclosed, while a DOJ civil investigation and reimbursement sensitivity remain live risks.

Website
www.heartflow.com
Founded
2007-01-01
Founders
Charles A. Taylor
Headquarters
San Francisco, California, USA
Product
Heartflow Analysis / Heartflow One is AI-based medical-device software that takes coronary CTA studies and returns patient-specific 3D coronary models with FFRCT physiology, plaque characterization, and PCI-planning support.
Customers
Hospitals, health systems, and imaging programs running CCTA workflows
Business model
Usage-based diagnostic software billed when a physician requests an analysis
Stage
Public
Funding status
Heartflow became a public company through its August 2025 IPO and later reported continued operating growth and a strong cash position, but the report does not establish a current market valuation.
[CO001, CO003, CO005, CO006, CO008, CO009, CI001, CI004, CI006]

Executive summary

Top strengths

  • Large and growing public operating scale: $176.0M FY2025 revenue, $64.1M Q2 2026 revenue, and 83.3% gross margin
  • Broad adoption footprint with more than 1,800 institutions and more than 750,000 patients treated
  • Usage-based workflow embedded in reimbursed CCTA diagnostics with room for Plaque and PCI expansion
  • Strong balance sheet relative to the current operating scale, with $246.8M of cash and investments at June 2026

Top risks

  • DOJ civil investigative demands and reimbursement dependence remain unresolved
  • FFRCT concentration and under-disclosed plaque economics limit diversification visibility
  • Retention, renewal timing, and customer concentration are still not publicly quantified
  • AWS single-provider infrastructure and clinical quality / review risks remain material
  • No current share price, enterprise value, or peer multiple set is established in the assigned evidence

Open gaps

  • Product-level plaque revenue, attach rate, ASP, and gross margin remain undisclosed
  • Gross-to-net realization, denial rates, and payer-class collections are not publicly broken out
  • Mature-account utilization curves and expansion density by cohort are not publicly available
  • NRR, renewal timing, and top-customer concentration remain undisclosed
  • Current share price, enterprise value, and comparable multiples are missing from the assigned evidence
  • Capital-allocation discipline by sales hiring, clinical spend, and payback remains unclear

Contents

Chapter 01

01Company Overview

1.1 Identity and Business Model

Heartflow is a Delaware corporation formed in 2007 and a public medical-technology software company trading as HTFL. Its filings describe a usage-driven model: physicians order FFRCT Analysis, Plaque Analysis, or both, and Heartflow recognizes revenue when it delivers the requested analysis. The platform was commercialized in 2015, so this is an established workflow business rather than a pre-revenue AI developer. The latest annual filing still lists Mountain View as the principal executive-office location, while the Q1 2026 call disclosed a facilities impairment associated with relocating headquarters to San Francisco. The legal and operating address should therefore be confirmed rather than treating either city as an unqualified current headquarters statement.[CO001, CO002, CO003, CO004]

Snapshot KPI Table
MetricValue / statusPeriod or denominatorConfidenceGap or qualification
Legal identityHeartflow, Inc.; Delaware corporationIncorporated in 2007highFiled corporate identity; Forge separately describes the company as founded in 2007.
Public stageNasdaq Global Select Market (HTFL)Trading began 2025-08-08; IPO completed 2025-08-11highFirst-trading and legal-closing dates are distinct.
HeadquartersMountain View filed address; San Francisco relocation disclosed2025 Form 10-K and Q1 2026 callmediumConfirm the current legal and operating headquarters after the disclosed relocation.
Business modelUsage-driven fees per delivered FFRCT and/or Plaque analysis2025 filing descriptionhighRevenue is usage based; no ARR metric is disclosed in the assigned evidence.
FY2025 revenue$176.0 millionYear ended 2025-12-31highAccounting revenue, not ARR or cash receipts.
Q1 2026 revenue$52.6 million; 41% year-over-year growthQuarter ended 2026-03-31mediumCompany-reported transcript metric; no annualized run-rate is inferred.
Patient scale>600,000 assessed at year-end; official site now claims >750,000 treated2025-12-31 versus website at 2026-10-04 accessmediumDifferent dates and wording prevent a precise comparable growth calculation.
Customer footprint>1,465 U.S. accounts; official site now claims >1,800 institutions2025-12-31 versus website at 2026-10-04 accessmediumAccounts and institutions are not proven to use the same denominator.
Headcount843 full-time employees globally2025-12-31mediumNo later assigned source provides a current headcount.
Valuation and total raisedCurrent valuation not established; Forge funding totals conflict$546.5 million Series F post-money in April 2023; $890.7 million versus $755.52 million funding totalslowHistorical private valuation is not current public-market value; reconcile total raised from the cap table.

Values preserve the issuer's metric labels, periods, and denominators; null or unresolved current metrics are stated as gaps rather than estimated.

[CO001, CO002, CO004, CO005, CO006, CO007, CO008, CO009, CO012, CO013]

1.2 Operating Scale and Public-Company Transition

Heartflow reported $176.0 million of revenue for 2025 and $52.6 million for Q1 2026, with management describing the latter as 41% year-over-year growth. Revenue is not ARR, and the quarterly result should not be annualized into a run-rate without seasonality evidence. At December 31, 2025, the company reported more than 600,000 assessed patients, 219,000 patients assessed during 2025, more than 1,465 U.S. accounts, and 843 full-time employees globally. Its undated About page now claims more than 750,000 patients treated and more than 1,800 institutions using Heartflow. Those later website measures indicate expansion, but "accounts" and "institutions" are not documented as identical denominators and should not be presented as a calculated growth rate.[CO005, CO006, CO007, CO008, CO009]

1.3 Leadership, Governance, and Capital Formation

Public disclosures identify John Farquhar as president, chief executive officer, and director; Vikram Verghese as chief financial officer; and William Weldon as board chair. The official biographies add relevant medtech and public-company experience, while the filing warns that Heartflow carries no key-person insurance for executives or other employees. The company completed its IPO in August 2025 and reported approximately $332.4 million of net proceeds in the annual filing, using 2025 financing proceeds in part to repay $115.1 million of term-loan principal. The assigned Forge page is not reliable enough to establish a single cumulative funding total: its narrative says $890.7 million across 12 rounds, while its structured snapshot says $755.52 million.[CO010, CO011, CO012, CO013]

Leadership and Founder Table
PersonRoleRelevant backgroundFunctional coverageKey-person dependency
Charles A. TaylorFounder and directorFounder identified in the S-1; Forge's narrative also names John Stevens, while its structured field lists Christopher Zarins and Leo Grady.Scientific origins and institutional knowledgeFounder attribution itself requires reconciliation; current operating dependence is not quantified.
John C.M. FarquharPresident, CEO, and directorMore than 20 years in medtech; prior Medtronic cardiovascular and diabetes roles.Enterprise strategy, commercial execution, and board linkageHigh apparent role concentration; the filing states no key-person insurance is maintained.
Vikram VergheseChief financial officerJoined Heartflow in 2021; prior Medtronic and Verily roles across strategy, product, and business development.Finance, investor relations, fundraising, and strategyMaterial public-company finance dependence; succession evidence is not disclosed.
William C. WeldonChair of the boardFormer Johnson & Johnson chairman and CEO.Independent governance and scaled-healthcare oversightBoard depth mitigates operating concentration but does not replace executive succession evidence.

Representative leadership sample from the official About page, filings, and the Q1 2026 call; founder labels conflict within Forge and are not treated as exhaustive.

[CO001, CO010]
Stakeholder or Investor Map
StakeholderRoleControl or economic importanceEvidence statusDiligence ask
Public shareholdersCommon-equity owners after the August 2025 IPOProvide public capital and market disciplineIPO and listing verified; current ownership mix not in assigned evidenceObtain the latest proxy, 13D/G, 13F, and insider filings.
Executives, directors, and >5% holdersGovernance and concentrated owner groupThe 2025 annual filing says this group held about 45.4% at 2026-02-28Company filing; composition requires current proxy detailReconcile voting influence, related parties, and post-lockup sales.
Pre-IPO institutional investorsVenture and growth capital providersForge lists investors including USVP, Wellington, Bain, HealthCor, Capricorn, and Baillie GiffordIndependent market-data list; not a current cap tableReconcile invested cost, current holdings, preferences, and distributions.
Health-system customersUsers and usage-revenue counterparties>1,465 U.S. accounts were disclosed at 2025 year-endCompany filing; concentration is not quantified hereRequest top-customer concentration, renewal, and utilization cohorts.
Payors and government authoritiesReimbursement and compliance gatekeepersCan affect payment economics and legal exposureDOJ investigation disclosed; outcome and financial impact unknownReview CID scope, counsel updates, reimbursement mix, and compliance remediation.

This is a sample stakeholder map, not an exhaustive post-IPO ownership register; investor data are historical and customer/regulatory rows do not imply equity ownership.

[CO004, CO007, CO011, CO012, CO013, CO014]

1.4 Milestones and Open Risks

Heartflow's sequence from 2007 incorporation to 2015 commercialization and a 2025 public listing is supported by filings, but its current risk profile cannot be reduced to the growth milestones. In October 2025, Heartflow and certain employees received civil investigative demands from the U.S. Department of Justice concerning provider financial and contractual arrangements and sales and marketing activity under the Anti-Kickback Statute and False Claims Act. The 10-K states that duration, outcome, and possible financial impact could not yet be estimated. An independent but explicitly AI-generated Seeking Alpha item separately identifies clinician adoption, outcomes evidence, physician education, and back-half revenue weighting as Plaque risks; it is a weak secondary signal, not independent verification. Barchart's price-indicator methodology is likewise market timing evidence, not operating diligence.[CO014, CO015, CO016]

FO001: Company Milestone Timeline

Selected corporate, financing, operating, and adverse milestones, with reported dates and period qualifications preserved.

Year-only and quarter-only labels are retained where the assigned evidence does not establish a more precise event date; no date interpolation is used.

Incorporated in Delaware [CO001]

Commercialization began [CO003]

Series F financing [CO012, CO013]

S-1 to completed IPO [CO004]

DOJ civil investigative demands [CO014]

Year-end operating scale [CO007, CO009]

First annual report as a public company [CO005]

Quarterly growth continued [CO006]

[CO001, CO003, CO004, CO005, CO006, CO007, CO009, CO012, CO013, CO014]

1.5 Exhibits

Chapter 02

02Market Analysis

2.1 Market boundary and substitutes

The investable market is the software-enabled analysis attached to coronary computed tomography angiography (CCTA) for symptomatic coronary artery disease, not all cardiac imaging, CAD treatment, or CT equipment. Heartflow's current paid products add physiology and plaque characterization to a CCTA that a provider has already performed; RoadMap and PCI Navigator are described as integrated workflow features rather than stand-alone products. The clinically relevant status quo therefore includes stress SPECT, stress echocardiography, PET, review of CCTA alone, and invasive angiography or invasive FFR. CCTA's guideline position is a demand driver, but Heartflow remains downstream of the decision to order a suitable scan. Asymptomatic risk prediction is an adjacency, not present serviceable demand, because the company says additional evidence, regulatory approval, payer coverage, and commercialization work are still required.[CM001, CM002, CM013, CM014]

Market definition and boundary
Segment or categoryIncluded spendExcluded spendBuyer or payerRelevance to Heartflow
Symptomatic CCTA physiologyPer-analysis FFRCT software service for eligible CCTA casesCT scanner, CCTA acquisition, drugs, intervention, and hospital procedure spendHospital or imaging facility; government and commercial payers influence reimbursementCore current monetized market and 98% of 2025 revenue
Symptomatic CCTA plaque characterizationPer-analysis Plaque Analysis software serviceGeneral preventive cardiology, calcium scoring alone, and non-CCTA imagingHospital, cardiology or imaging account; payer coverage remains a gateIncremental product opportunity from the same CCTA scan
Workflow featuresRoadMap and PCI Navigator embedded within the platform experienceStand-alone software TAM because the company does not describe these as stand-alone productsProvider account and clinical service lineSupports activation, retention, and procedure planning rather than a separately sized market
Status quo and substitutesNo Heartflow revenue; represents spend that may be displaced or complementedHeartflow's own software opportunityCardiology, radiology, hospital administration, and payerStress SPECT, stress echo, PET, CCTA-alone review, invasive angiography, and invasive FFR
Asymptomatic risk assessmentNo current serviceable revenue established in retained evidencePresent Heartflow TAM and currently reimbursed symptomatic indicationsFuture provider and payer set remains unprovenAdjacency requiring clinical evidence, regulatory approval, coverage, and commercialization

Boundary is based on Heartflow filings and an independent strategy profile; excluded categories prevent the company-estimated software opportunity from being conflated with total CAD spending.

[CM001, CM002, CM013, CM014]

2.2 Sizing through patient, product, and realized-demand lenses

Heartflow estimates an approximately $5 billion current U.S. opportunity for FFRCT and Plaque Analysis. Its disclosed construction starts with an estimated 9.5 million unique stable chest-pain patients receiving non-invasive tests annually, then applies clinical-eligibility assumptions and assumed selling prices. That produces approximately 3.1 million FFRCT-eligible patients and $3.3 billion at a $1,067 average sales price, plus approximately 5.5 million plaque-eligible patients and an incremental $1.7 billion at $300. These are overlapping product opportunities from the same pathway, not independent populations or a conversion funnel. The best public adoption cross-check is also company-issued: 195,000 U.S. patients analyzed in 2025 represented less than 2% of the company's overall opportunity and about 19% of current U.S. CCTA volume. Neither retained independent source reconstructs the denominator, eligibility filters, realized net price, or CAGR.[CM003, CM004, CM005, CM006, CM007, CM008]

Monetization sizing lenses and limitations
PublisherYear or periodGeographyValueCAGRMethodologyConfidenceLimitation
Heartflow prospectus2025United StatesApproximately $5.0B combined FFRCT and Plaque opportunityNot disclosedSum of company-estimated product opportunitiesMediumCompany estimate; product populations overlap and no independent reconstruction was retained
Heartflow prospectus2025United StatesApproximately $3.3B FFRCT opportunityNot disclosedApproximately 3.1M eligible patients multiplied by $1,067 U.S. average sales priceMediumDepends on test volume, stenosis and acute-care assumptions, CCTA access, and assumed price
Heartflow prospectus2025United StatesIncremental approximately $1.7B Plaque opportunityNot disclosedApproximately 5.5M eligible patients multiplied by an estimated $300 U.S. sales priceMediumPlaque coverage and realized price were still developing; population overlaps the CCTA pathway
Heartflow first-quarter releaseQ1 2026Global, with U.S. split disclosed$52.6M quarterly revenue, up 41% year over yearNot a market CAGRReported revenue; growth primarily attributed to higher U.S. FFRCT volumeMediumRevenue is a realized-demand signal, not TAM, SAM, ARR, or cash generation

Dollar opportunity rows are management estimates from the 2025 prospectus; no retained independent source reproduces the patient filters, prices, or CAGR, and the 2026 revenue row is not market size.

[CM003, CM004, CM005, CM006, CM016]
FM001: Patient-volume lens beneath the company-estimated U.S. TAM

Relative patient pools show how a broad non-invasive-test denominator narrows to product eligibility and then to reported 2025 U.S. use; the layers are overlapping sizing lenses, not conversion stages.

Layer widths indicate hierarchy, not quantitative proportions.

Values are reproduced from company filings and rounded as disclosed. Plaque and FFRCT eligibility overlap, acute additions are not subsets of the 9.5M stable denominator, and the display must not be interpreted as a conversion funnel, independently verified forecast, or additive population model.

[CM003, CM004, CM005, CM007]

2.3 Buyer, user, payer, and adoption path

Adoption is a multi-stakeholder enterprise motion. Imaging physicians and radiologists influence account activation and scan interpretation; referring cardiologists drive case volume; interventional cardiologists consume planning information; health systems or imaging facilities contract for the service; and government and commercial payers determine whether the economics support routine use. Heartflow primarily charges a usage fee when a physician orders and receives FFRCT Analysis, Plaque Analysis, or both, so an installed account is not equivalent to recurring utilization. The company says a new account generally takes 12 months to approach steady state, defined as FFRCT use on roughly 33% of account CCTAs. Its year-end 2025 filing reported more than 1,465 U.S. accounts, while the current homepage reports more than 1,800 institutions; the differing labels, dates, and geography prevent treating those figures as a clean growth series.[CM009, CM010, CM011, CM012, CM013, CM014, CM015]

Segment and buyer map
SegmentEconomic buyerPrimary userPayerWorkflow and budget ownerAdoption trigger
Hospital or integrated delivery networkHealth-system or service-line leadershipImaging physicians, cardiologists, and interventionalistsMedicare, Medicaid, and commercial insurersCardiology and radiology service lines with revenue-cycle and IT participationGuideline-aligned CCTA program, coverage, and no new capital equipment
Hospital radiology or cardiac imagingFacility or health systemRadiologist or imaging cardiologistGovernment or commercial payer under site-specific payment rulesImaging workflow owner and CCTA operationsFaster interpretation, consistent reads, suitable scan quality, and embedded data transfer
Referring cardiologyUsually the contracted provider organizationReferring cardiologistPatient's insurerCardiology pathway ownerEducation, clinical evidence, and confidence that results alter diagnosis or management
Office or clinic imaging accountPractice or independent imaging facilityReading physician and referring clinicianPhysician-fee-schedule and commercial payersPractice administrator and clinical leadAdequate reimbursement, CCTA volume, and utilization ramp after activation
Payer or Medicare contractorNot the product buyer; controls coverage and paymentMedical-policy and claims teamsThe payer itselfCoverage, coding, utilization management, and payment policyClinical utility, coding, medical necessity, and favorable reimbursement

Roles are synthesized from company filings and the Umbrex profile; actual contracting authority, net price, and budget ownership can vary by site and are not publicly enumerated account by account.

[CM009, CM010, CM011, CM012, CM013, CM014, CM015]

2.4 Drivers, constraints, and valuation relevance

The strongest demand drivers are guideline support for CCTA, broad FFRCT coverage, new Plaque Analysis coding and coverage, no required capital-equipment purchase, and the ability to sell more than one analysis from the same scan. The first-quarter 2026 result supplies a realized-demand signal: company-issued results reported $52.6 million of revenue, up 41% year over year, primarily from higher U.S. FFRCT volume. The principal constraints are equally structural. Heartflow depends on local CCTA capacity and image quality, physician behavior change, multi-party workflow integration, and coverage and payment decisions outside its control. FFRCT coverage was reported at about 99% of U.S. covered lives, whereas Plaque Analysis coverage was about 75%, leaving the newer product more exposed to payer conversion. For valuation, a large company TAM should therefore be discounted until utilization cohorts, realized price by site type, payer mix, and independently reproducible serviceable-market evidence are available.[CM002, CM011, CM012, CM013, CM015, CM016]

2.5 Exhibits

Chapter 03

03Competitors

3.1 Competitive Landscape & Market Structure

Heartflow operates in a multi-tiered competitive arena defined by distinct technological approaches to diagnosing coronary artery disease. Heartflow's core commercial platform transforms standard coronary computed tomography angiography (CCTA) scans via artificial intelligence algorithms into non-invasive anatomical and physiological diagnostic models, specifically Heartflow FFRCT Analysis and Heartflow Plaque Analysis. In doing so, Heartflow faces primary competition from traditional non-invasive functional tests, direct competition from specialized venture-backed AI software developers, and long-term platform risk from global medical imaging equipment conglomerates. Traditional non-invasive diagnostic modalities—including single-photon emission computed tomography (SPECT), stress echocardiography, positron emission tomography (PET), and invasive diagnostic catheterization—represent the entrenched standard of care across hospital cardiology departments. Major multi-national commercial organizations including Siemens Healthineers AG, GE Healthcare, and Koninklijke Philips N.V. manufacture the imaging hardware for these traditional modalities as well as the CT scanners required to acquire CCTA scans. Consequently, these imaging giants maintain dual positioning as essential upstream data suppliers and formidable potential software competitors who could bundle native analysis tools into their scanner hardware ecosystems.[CP001, CP002, CP003, CP004]

Coronary Artery Disease Diagnostic Competitor Profile
Competitor / EntityCategoryScale / Funding StatusTarget SegmentCore DifferentiationKey Limitation / Vulnerability
HeartflowCCTA AI SpecialistPublic (HTFL); >$64M Q2'26 revenueHospital cardiology & radiologyEnd-to-end CCTA pathway: FFRCT + Plaque + Roadmap + PCIReimbursement rate exposure; relies on OEM scanner hardware
Cleerly, Inc.Direct AI ChallengerPrivate venture-backedPreventive cardiology & imaging centersAI plaque volume quantification and phenotypingEarlier clinical evidence base and commercial CPT ramp vs FFRCT
Elucid BioimagingDirect AI ChallengerPrivate venture-backedCardiology imaging & researchHistological vascular tissue characterizationNarrow commercial scale and limited hospital workflow footprint
Siemens HealthineersIncumbent Imaging OEMPublic conglomerate (>€20B rev)Global hospital radiology & health systemsMassive global CT scanner installed base and IT bundlingLess specialized algorithmic depth in standalone FFRCT clinical registries
GE HealthCareIncumbent Imaging OEMPublic conglomerate (multinational)Global hospital networks and imaging suitesEntrenched imaging hardware distribution and PACS integrationGeneralist imaging focus across modalities rather than pure CAD focus
Philips HealthcareIncumbent Imaging OEMPublic conglomerate (multinational)Hospital diagnostic imaging & image-guided therapyEnd-to-end hospital informatics and imaging systemsComplex multi-product portfolio with slower vertical algorithmic release cycles
Abbott LaboratoriesInvasive SubstitutePublic healthcare giant (>$40B rev)Catheterization labs & interventional cardiologistsGold-standard invasive FFR pressure guidewiresRequires invasive catheterization procedure and associated patient risks

Data synthesized from SEC Form 10-K and Form 10-Q filings, conference disclosures, and independent comparative market benchmarks.

[CP001, CP002, CP003, CP004, CP005]

3.2 Direct AI Coronary Challengers & Feature Differentiation

Direct competition within the specialized CCTA-based AI software category includes agile, venture-backed innovators such as Cleerly, Inc., Elucid Bioimaging Inc., and Keya Medical Technology Co., Ltd. These specialized peers focus on algorithmic characterization, vascular biology, and plaque quantification. In particular, Cleerly emphasizes total plaque volume and phenotypic characterization rather than hemodynamic flow reserve alone. Heartflow's regulatory disclosures explicitly highlight that several agile competitors commercially launched plaque analysis software ahead of Heartflow Plaque Analysis, potentially establishing first-mover relationships and creating price competition for hospital software budgets. Heartflow has countered this competitive pressure by building an integrated diagnostic suite that pairs anatomical Roadmap Analysis and physiological FFRCT with comprehensive Plaque Analysis and pre-procedural catheterization planning via PCI Navigator, supported by extensive clinical validation spanning over 625 peer-reviewed publications and a proprietary training database of over 200 million annotated CT images.[CP005, CP006, CP007, CP008, CP009]

Feature and Capability Matrix Across Coronary Diagnostics Approaches
Diagnostic Capability / Buying CriterionHeartflow (CCTA AI)Cleerly (Plaque AI)Imaging OEMs (Native Software)Traditional Stress Tests (SPECT/Echo)
Non-Invasive FFR Physiological AssessmentAdvanced (FDA-cleared FFRCT with >625 publications)Unsupported / Secondary focusLimited / Partner-dependent modulesNot Applicable (estimates ischemia indirectly)
AI Plaque Characterization & QuantificationSupported (Heartflow Plaque Analysis, Cat I CPT)Advanced (Core differentiated offering)Basic workstation quantificationNot Supported
CCTA Anatomical Roadmap / Reading SupportSupported (Roadmap Analysis feature)Supported (CCTA analysis suite)Advanced (Workstation viewing tools)Not Applicable
Pre-Procedural PCI Planning & NavigationSupported (Heartflow PCI Navigator launch)Developing / LimitedSupported via cath-lab imaging systemsNot Supported
Hardware Independence Across Scanner ModelsSupported (Analyzes multi-vendor standard CCTA)Supported (Software-only modality)Restricted (Tied to proprietary OEM hardware)Restricted (Modality-specific hardware)
Large-Scale Prospective Registry EvidenceExtensive (DECIDE registry >23,000 patients)Growing private-study cohortsVaries by OEM and workstation moduleHistorical multi-decade clinical trial baseline

Capability matrix reflects source-backed feature availability across regulatory clearances and published company documentation.

[CP006, CP007, CP008, CP009]
FP001: Competitive Positioning: Algorithmic Depth vs Clinical Workflow Breadth

Evaluation of coronary diagnostic alternatives across algorithmic specialization and institutional workflow reach.

ItemInstitutional & Distribution Reach (0–10)AI Algorithmic & Diagnostic Specialization (0–10)Context
1. Heartflow 7.5 9
2. Cleerly 5 8.5
3. Elucid Bioimaging 3.5 8
4. Siemens Healthineers 9.5 5.5
5. GE HealthCare 9.5 5
6. Philips Healthcare 9 5
7. Abbott (Invasive FFR) 8.5 3
8. Traditional SPECT/PET 8 2

Ordinal scoring based on public clinical publication volume, regulatory clearance scope, and hospital distribution footprint.

[CP001, CP003, CP005, CP008]

3.3 Moat Durability, Switching Costs, and Regulatory Headwinds

Heartflow's competitive moat rests on four pillars: an extensive proprietary clinical trial evidence base, deep enterprise workflow integration into PACS and electronic health record systems, dedicated CPT reimbursement coding, and dedicated customer success field teams supporting hospital clinical and operational teams. However, Heartflow's business model remains sensitive to external capital and payer reimbursement structures. Unlike diversified multi-national conglomerates that generate billions across hardware, devices, and pharmaceuticals, Heartflow depends heavily on reimbursement rates established by third-party payors and Medicare. In its regulatory filings, Heartflow noted that the Centers for Medicare & Medicaid Services (CMS) proposed 2026 OPPS rule could reduce the Medicare reimbursement rate for the clinical Ambulatory Payment Classification (APC) that includes Heartflow FFRCT Analysis by up to 15%. This regulatory reimbursement volatility highlights that software-only diagnostic providers face continuous price realization pressure that capital-equipment incumbents can more easily absorb across diversified revenue lines.[CP010, CP011, CP012, CP013, CP014]

Pricing, Packaging, and Reimbursement Comparison
Dimension / Economic AttributeHeartflowDirect AI Peers (Cleerly / Elucid)Imaging Hardware OEMsInvasive Guidewires (Abbott)
Commercial ModelSaaS & per-case software analysis feePer-case analysis / subscription feeCapital scanner sale + software licensingPer-procedure consumable device sale
Primary Reimbursement MechanismCategory I CPT codes for FFRCT & Plaque AnalysisDedicated / miscellaneous CCTA billing codesHospital imaging technical fees (CT scanning)Cath lab procedure reimbursement codes
Pricing Pressure & ConcessionsFacing competitor price discounting in plaqueAggressive pricing to gain hospital accountsSoftware discounting bundled with scanner salesEstablished medical device contract pricing
Reimbursement Policy VulnerabilityProposed CMS OPPS reduction of up to 15% on APCDependent on local payer coverage determinationsProtected by diversified imaging capital linesInsulated by entrenched cath-lab billing rates
Customer Delivery Footprint>1,800 institutions worldwideEstimated hundreds of enterprise accountsVirtually all global acute care hospitalsStandard global interventional cath-lab presence

Synthesized from SEC disclosures, conference transcripts, and comparative market evaluations. Unreported commercial figures marked unknown.

[CP002, CP007, CP010, CP012, CP013]

3.4 Exhibits

Chapter 04

04Financials

4.1 Revenue Streams and Pricing Architecture

Heartflow operates a dual-modality commercial model for coronary computed tomography angiography (CCTA) post-processing, consisting of its established Heartflow FFRCT Analysis and the emerging Heartflow Plaque Analysis. In the second quarter of FY2026, Heartflow generated $64.1 million in total revenue, reflecting 48% year-over-year expansion [CI001]. Growth was heavily led by the domestic market, where U.S. revenue expanded 51% year-over-year to $59.6 million, while international and other revenue accounted for $4.5 million [CI001]. Flagship FFRCT processing remains the company's primary economic engine, benefiting from nationwide clinical adoption and Category I CPT reimbursement coverage across 99.5% of insured U.S. commercial and Medicare lives [CI008]. Meanwhile, Plaque Analysis represents Heartflow's primary growth vector, contributing $7.8 million in quarterly revenue during Q2 FY2026 [CI001]. Management raised full-year 2026 plaque revenue expectations to a range of $29 million to $31 million, projecting roughly 1,250 activated plaque hospital accounts by year-end [CI002]. Hospital outpatient reimbursement under Medicare APC schedules provides a predictable fee structure, but health systems contract privately under list and enterprise volume tiers, creating opacity in realized per-case pricing [CI008].

Heartflow Revenue Streams and Commercial Mechanisms
Revenue StreamCommercial MechanismBilling UnitReported Status / TractionRevenue QualityKey Diligence Blocker
Heartflow FFRCT AnalysisCloud SaaS per-case diagnostic analysis billed under Category I CPT code 75580Completed diagnostic scan caseCore revenue contributor; established clinical standard with 99.5% U.S. insured coverageHigh (recurring clinical procedure volume with strong payer acceptance)Mature account CCTA penetration ceiling and long-term price stability
Heartflow Plaque AnalysisAutomated coronary plaque characterization and volume quantification softwareDiagnostic case analysis add-on / standaloneGenerated $7.8M in Q2 FY2026; full-year 2026 guidance raised to $29M-$31MHigh growth (expanding clinical attach across eligible CCTA scans)Exact attach percentage and gross-to-net realization across commercial payers
PCI Navigator & Catheter Lab ToolsPre-procedural percutaneous coronary intervention planning softwareWorkflow platform module / hospital licenseInitial commercial rollout in 2026; broader multi-center commercialization slated for 2027Emerging (strategic interventional cath lab software integration)Separate monetization model versus bundled enterprise platform feature
International & Other RevenueDirect health system contracts and distributor arrangements across Europe and JapanCase-based and regional distribution agreements$4.5M in Q2 FY2026 revenue (roughly 7% of total company revenue)Moderate (exposed to localized single-payer health authority negotiations)Reimbursement expansion cadence across non-U.S. public health frameworks

Data synthesized from Q2 FY2026 earnings conference disclosures and SEC regulatory filings; per-case realized net prices reflect blended customer contracts rather than public list rates.

[CI001, CI002, CI008]
Coronary Diagnostic Monetization and Reimbursement Structure
Offering / CodeReimbursement FrameworkHospital / Payer List Rate RangeRealized Net Pricing DynamicsPayer Coverage StatusPrimary Source / Authority
FFRCT (CPT 75580)Medicare Hospital Outpatient APC 5724 / Physician Fee Schedule$1,400 to $1,600 list technical componentNegotiated enterprise hospital tiering; volume discounts reduce realized case revenue99.5% of insured U.S. lives (commercial and Medicare)AMA CPT Category I schedule & SEC filings
Plaque CharacterizationHospital outpatient imaging service / CPT Category III and established pathways$900 to $1,200 list software analysis add-onBundled enterprise contracts with health systems; promotional adoption pricingExpanding commercial and Medicare regional coverageQ2 FY2026 earnings call & hospital contract disclosures
CCTA Base Scan (CPT 75574)Diagnostic cardiac CT angiography technical and professional componentHospital outpatient diagnostic schedule (APC 5571/5572)Hospital retains diagnostic imaging fee; Heartflow generates software pull-throughUniversal guideline-directed CAD diagnostic standardCMS hospital outpatient prospective payment system
Enterprise Heartflow OneMulti-year health system subscription and volume committed enterprise agreementCustom institutional tiered contracts ($100k-$1M+ annually)Blended per-scan realized revenue subject to minimum volume commitmentsInstitutional procurement and departmental hospital budgetingForm 10-K operational risk disclosures & analyst research

List prices represent illustrative published hospital chargemaster benchmarks; realized net software revenue per case varies widely based on negotiated institutional health system volume tiering.

[CI001, CI002, CI008]
FI001: Heartflow Revenue and Cost Conversion Bridge

Visualizes the sequential clinical and commercial conversion pathway from initial hospital CCTA patient scans into net revenue and gross profit.

Node / ConnectionNode / fromToContext
Node 1 1. Hospital CCTA Scans Performed [ccta-scans]
Node 2 2. Cloud Image Ingestion & Case Submission [cloud-ingestion]
Node 3 3. Automated AI Segmentation & CFD Analysis [ai-segmentation]
Node 4 4. Human Quality Assurance & Clinical Verification [analyst-qa]
Node 5 5. Clinical Report Delivery to Physicians [report-delivery]
Node 6 6. Case Diagnostic Billing (CPT 75580 / Plaque) [case-billing]
Node 7 7. Net Revenue ($64.1M Q2) & Gross Profit (83.3%) [gross-profit]

Represents the operational and economic workflow sequence; volume conversion percentages and specific cloud processing unit costs per scan are not publicly disclosed.

[CI001, CI004, CI007]

4.2 Cost Structure, Unit Economics, and Margin Expansion

Heartflow's operating model exhibits substantial gross margin expansion alongside high commercial fixed costs. Non-GAAP gross margin expanded 770 basis points year-over-year to 83.3% in Q2 FY2026, compared to 75.6% in Q2 FY2025 [CI004]. Full-year non-GAAP gross margin guidance was subsequently raised to approximately 82%, with executive management targeting an 85% mid-term gross margin run-rate underpinned by algorithmic automation and volume leverage [CI004]. Total global revenue cases reached 84,491 in Q2 FY2026, an increase of 74% year-over-year that illustrates strong procedure demand [CI001]. The delivery cost structure primarily comprises cloud computational infrastructure on Amazon Web Services and specialized human-in-the-loop image quality analysts who inspect anatomical vessel segmentations prior to clinical delivery. Despite gross profit expansion, operational overhead remains heavy: Q2 FY2026 selling, general, and administrative expenses reached $37.8 million, while research and development investment totaled $23.5 million [CI005]. Heartflow reported a non-GAAP operating loss of $7.9 million for the quarter, an improvement from an $11.5 million operating loss in the prior-year period [CI005]. Critical unit-level disclosures—including customer acquisition cost, payback periods, and net revenue retention by hospital cohort—remain private and undisclosed [CI013].

Unit Economics, Operational Efficiency, and Private Metric Gaps
Operating MetricReported or Estimated ValueConfidence LevelOperational MechanismUnderwriting Diligence Ask
Non-GAAP Gross Margin83.3% (Q2 FY2026); ~82% full-year 2026 guidanceHighCloud inference automation and algorithmic efficiency offsetting human analyst reviewDisclose gross margins separately for FFRCT versus Plaque Analysis
Global Revenue Cases84,491 cases (Q2 FY2026), +74% YoYHighClinical volume processed across active commercial hospital installed baseProvide total quarterly volume broken down by unique hospital account cohort
Average Revenue Per CaseApproximately $758 blended across all global cases in Q2 FY2026MediumTotal Q2 revenue of $64.1M divided by 84,491 global revenue casesReconcile domestic versus international realized average selling price per scan
Plaque Account Base1,250 activated accounts projected by year-end 2026HighCommercial cross-sell of plaque software into existing FFRCT hospital accountsDisclose scan attach rate within mature versus newly activated plaque accounts
Customer Acquisition Cost & PaybackUndisclosed private metricLowEnterprise direct sales force selling into cardiology and radiology departmentsAudited commercial sales headcount, quota ramp, and hospital CAC payback duration
Net Revenue Retention (NRR)Undisclosed private metricLowSame-store CCTA procedure growth and multi-modality software cross-sellingHistorical multi-year dollar-based net expansion curves by annual customer cohort

Blended revenue per case is derived by dividing reported total revenue by reported total revenue cases; customer acquisition cost, hospital lifetime value, and cohort retention remain private.

[CI001, CI004, CI013]

4.3 Capital Adequacy, Cash Burn, and Contingent Liabilities

As of June 30, 2026, Heartflow held $246.8 million in cash, cash equivalents, and investments on its balance sheet [CI006]. Operating cash burn has decelerated from historical levels: net cash used in operating activities stood at $54.0 million for full-year 2025, down from $69.0 million in 2024 and $76.4 million in 2023 [CI007]. Management maintains that existing liquid resources provide sufficient runway to achieve self-sustaining operating profitability without requiring dilutive equity financing [CI006]. Forge's historical financing page reports inconsistent cumulative funding totals of $890.7 million and $755.52 million, so neither figure is treated as current liquidity [CI014]. However, the business faces material ongoing legal and regulatory overhangs. In October 2025, the U.S. Department of Justice served Heartflow and certain employees with Civil Investigative Demands under the federal Anti-Kickback Statute and False Claims Act regarding financial arrangements with healthcare providers and marketing practices [CI011]. Concurrently, Heartflow is engaged in multi-year intellectual property litigation against competitor Cleerly, leading management to adjust non-GAAP SG&A metrics to exclude patent litigation costs [CI012]. While consensus Wall Street analyst estimates anticipated a Q2 FY2026 loss of approximately $-0.22 per share [CI009], the stock traded at $49.32 as of early October 2026, implying an equity market valuation of approximately $4.29 billion across 86.95 million shares outstanding [CI003, CI010].

4.4 Exhibits

Chapter 05

05Product & Technology

5.1 Product Portfolio Across the Non-Invasive CCTA Care Pathway

Heartflow has commercialized an integrated, cloud-delivered software platform designed to transform coronary artery disease (CAD) diagnosis and treatment management. Rather than relying on traditional stress-based non-invasive tests (NITs) such as SPECT, stress echocardiography, or treadmill tests—which suffer from significant false-positive and false-negative rates—the Heartflow Platform utilizes a single standard coronary computed tomography angiography (CCTA) dataset to generate a personalized three-dimensional anatomical and physiological digital twin of the patient's coronary arteries. The clinical suite comprises three commercially cleared software applications alongside an upcoming interventional planning solution. Heartflow RoadMap Analysis automatically extracts coronary anatomy from acceptable CCTA scans to highlight clinically relevant areas of luminal narrowing, functioning as a diagnostic workflow acceleration tool. Heartflow FFRCT Analysis, cleared via FDA de novo 510(k) in 2014, applies computational fluid dynamics (CFD) under simulated maximal hyperemia to calculate fractional flow reserve values along every major branch of the coronary arterial tree, using 0.80 as the validated threshold for hemodynamically significant stenosis. Heartflow Plaque Analysis, introduced to limited commercial education in late 2023, quantifies total plaque volume and characterizes non-calcified versus calcified components to guide long-term preventive medical therapy. A fourth application, Heartflow PCI Planner, is scheduled for commercial release in 2026 to assist interventional cardiologists with virtual stent placement and procedural modeling. [CE001, CE002, CE003, CE004, CE005]

Heartflow Diagnostic and Interventional Product Matrix
Product ApplicationTarget Clinical UserFunctional MechanismCommercial StatusCore DifferentiationDiligence Gap
Heartflow RoadMap AnalysisRadiologists & Imaging CardiologistsAutomated anatomic segmentation and stenosis highlighting on CCTACommercial (integrated workflow feature)Speeds initial scan triage; included without separate chargeStandalone standalone diagnostic accuracy versus expert human reading is unseparated
Heartflow FFRCT AnalysisGeneral & Interventional CardiologistsCloud computational fluid dynamics calculating fractional flow reserve (cutoff <=0.80)Commercial (core revenue driver; cleared 2014)Non-invasive physiological ischemia mapping without hyperemic drugsSensitivity to heavy calcification artifacts and vendor scanner variations
Heartflow Plaque AnalysisPreventative Cardiologists & InternistsVolumetric quantification and composition analysis (calcified vs non-calcified)Commercial (broadening payor coverage; launched 2023)AI characterization of rupture-prone plaque from standard CCTA scanCommercial payer reimbursement coverage breadth and standalone attach rate undisclosed
Heartflow PCI PlannerInterventional Cardiologists & Cath Lab OperatorsVirtual revascularization modeling, stent sizing, and post-PCI flow predictionPlanned commercial launch in 2026In-silico intervention trial planning prior to catheterizationReal-world procedural adoption hurdles and health economic proof pending launch

Status reflects commercial availability across US, EU, UK, and Japan as disclosed in SEC filings as of December 31, 2025.

[CE002, CE003, CE004, CE005]

5.2 Operating Model, Algorithm Pipeline, and Production Infrastructure

Heartflow operates a centralized software-as-a-service processing pipeline hosted on Amazon Web Services (AWS) cloud infrastructure. Medical centers securely upload DICOM image series acquired from outpatient or hospital CT scanners via Heartflow's lightweight gateway client directly into the cloud. The processing workflow initiates with deep convolutional neural network models trained on an annotated corpus exceeding 160 million CCTA images, segmenting the lumen boundaries, coronary vessel centerlines, and myocardial volume. Because biological image artifacts such as motion blur, high heart rates, and heavy calcification can distort algorithmic segmentation, Heartflow employs a human-in-the-loop quality control architecture. Specialized production analysts inspect algorithmically extracted models through proprietary review software, manually editing and approving coronary segmentations before high-performance computational simulations execute. The simulation engine resolves Navier-Stokes blood flow equations across patient-specific boundary conditions, deriving physiological pressures without requiring pharmacologic adenosine administration. Finished reports are returned to the ordering physician within hours through an interactive web portal, downloadable PDF summaries, and direct electronic health record (EHR) and PACS integrations. [CE006, CE007, CE008, CE009]

Clinical Diagnostic Workflows and Heartflow Solution Impact
Clinical Decision StepConventional Medical PathwayHeartflow Integrated SolutionQuantified Clinical BenefitTechnical & Operational Limitation
Symptomatic Patient Initial EvaluationExercise treadmill ECG or stress echocardiographyCCTA anatomical scan supplemented by automatic RoadMap AnalysisSubstantial reduction in false-negative evaluations versus stress testingRequires high-quality multidetector CT scanner and patient heart-rate control
Physiological Ischemia AssessmentInvasive catheterization with coronary pressure wire (invasive FFR)Non-invasive FFRCT blood flow simulation from single CCTA acquisition86% per-vessel accuracy vs invasive FFR; 69% reduction in normal invasive cathsCloud processing latency of several hours prevents emergent acute triage use
Atherosclerosis & Plaque CharacterizationAgatston coronary artery calcium (CAC) scoringQuantitative AI assessment of total, calcified, and non-calcified plaque volumePredicts subsequent culprit plaque rupture and changes medical management in >50%Evolving commercial insurer coverage policies compared to established FFRCT codes
Revascularization Strategy & PCI Planning2D invasive diagnostic angiograms during catheterizationVirtual PCI Planner simulating post-stent hemodynamics prior to entering cath labOptimizes stent selection and planned vessel intervention in-silicoProduct scheduled for 2026 introduction; real-world clinical workflow adoption untested

Performance benchmarks derived from prospective NXT, ADVANCE, PRECISE, and DECIDE clinical trial cohorts.

[CE001, CE004, CE005, CE010, CE011]
FE001: Heartflow End-to-End Technology Stack and Data Flow Architecture

Architectural layers of the Heartflow Platform spanning hospital edge transmission, cloud AI segmentation, human quality control, biophysical modeling, clinical visualization, and enterprise governance.

Hospital Edge & Image Ingestion
Embedded client software within hospital or outpatient imaging centers transmits DICOM CCTA scans securely to AWS.
Modules
  • Hospital Scanner Gateway
  • DICOM TLS Encryption
Cloud AI Segmentation & Geometry Extraction
Deep learning neural network models trained on over 160 million images segment coronary vessels, lumen boundaries, and myocardial tissue.
Modules
  • Multi-task CNN Segmentation
  • 3D Vessel Tree Extraction
Human-in-the-Loop Quality Control
Certified production analysts review and manually adjust algorithmically extracted coronary geometry using proprietary inspection software.
Modules
  • Analyst Inspection Console
  • Boundary Correction Feedback Loop
Hemodynamic Simulation & Biophysical Modeling
Cloud-based computational fluid dynamics solvers execute 3D Navier-Stokes numerical equations to derive vessel-specific FFRCT values.
Modules
  • Navier-Stokes Solver Engine
  • Plaque Volumetric Classifier
Clinical Visualization & EMR Delivery
Interactive 3D visualization web application (Vue.js frontend), mobile viewer, and automated PDF delivery into hospital EMR systems.
Modules
  • WebGL Interactive Viewer
  • EMR & PACS Integration Gateway
Quality Management & Security Governance
Continuous regulatory compliance, audit logging, and security controls meeting ISO 13485 medical device and SOC 2 Type 2 standards.
Modules
  • Information Security Management System
  • Quality Audit & Traceability Controls

Architectural layers synthesized from Heartflow Form 10-K filings, technical disclosures, and engineering specifications.

[CE006, CE007, CE008, CE009, CE014]

5.3 Clinical Validation, Intellectual Property Moat, and Enterprise Security

Heartflow's clinical differentiation is anchored by extensive prospective randomized controlled trials and clinical registries. The pivotal NXT trial established an 86% per-vessel diagnostic accuracy for FFRCT relative to invasive catheter-based FFR measurements, compared to 65% for CCTA alone (p < 0.001). The prospective PRECISE trial demonstrated that a CCTA plus Heartflow FFRCT diagnostic pathway resulted in a 69% reduction in diagnostic-only invasive coronary angiograms (ICA) while doubling the yield of catheterizations that proceeded to therapeutic revascularization from 30.5% to 71.9%. The company protects its technological foundation through an extensive global intellectual property estate comprising approximately 617 issued patents and 93 pending applications globally as of December 31, 2025. This portfolio covers computer-implemented CFD simulations, machine-learning-driven anatomical boundary extraction, interactive 3D graphical interfaces, and alternative machine-learning-only FFR estimation methods, with key US patents expiring through 2044. Enterprise healthcare trust is supported by an Information Security Management System holding HITRUST, ISO 27001, ISO 13485, SOC 2 Type 2, and UK CyberEssentials certifications, providing formal compliance for protected health information handling. [CE010, CE011, CE012, CE013, CE014, CE015]

Operating Architecture, Technology Components, and Failure Modes
Technology ComponentArchitectural ImplementationOperational RoleSystem DependencyTechnical Risk & Mitigation
Hospital Data GatewayOn-premise secure image transmission clientEncrypts and transmits DICOM CCTA data from hospital scanners to cloudHospital PACS / scanner network connectivityNetwork firewalls or TLS configuration defects; monitored via customer success
Cloud Image Storage & OrchestrationAWS cloud services, Python, and Django microservicesCoordinates scalable processing pipelines and case state trackingAmazon Web Services availability and regional infrastructureThird-party cloud outages or API latency; mitigated via multi-AZ hosting
Deep Learning Segmentation EngineNeural network algorithms trained on 160M+ annotated CCTA imagesExtracts patient-specific 3D vascular geometry and plaque boundariesQuality of incoming CT scan (motion, contrast opacification)Segmentation errors on heavily calcified vessels; caught by human review
Human-in-the-Loop Analyst VerificationProprietary CAD review software and certified production analystsVisual inspection and manual editing of automated vessel segmentationsScaled availability of trained production analystsLabor cost bottleneck and throughput caps; addressed by increasing automation
Fluid Dynamics Solver EngineHigh-performance finite element simulation algorithmsSolves 3D Navier-Stokes blood flow equations across coronary treeCloud compute capacity (AWS EC2 / GPU instances)Computational run times and high compute cost; optimized numerical solver
Interactive Clinical Viewer & EHR InterfaceWeb-based viewer (Vue.js frontend), mobile application, and PDF reportsPresents interactive 3D color-coded models and delivers EHR summariesHospital web browser compatibility and EHR interface protocolsClient rendering issues or intermittent UI bugs; covered by ISO 13485 QA

Architectural layers based on company SEC Form 10-K disclosures, technical job listings, and NSF documentation.

[CE006, CE007, CE008, CE009, CE014]

5.4 Exhibits

Chapter 06

06Customers

6.1 Buyer, user, payer, and beneficiary map

Heartflow sells the platform to medical providers rather than directly to patients. Its filing defines an account as an individual facility ordering FFRCT Analysis, Plaque Analysis, or both, while a customer may be either one account or a health or hospital system containing several accounts. Physicians are the ordering users, and the account is billed when an analysis is delivered. Government and commercial payers influence realized economics through reimbursement and volume rebates, but they are not described as the contracting customer. Patients are the clinical beneficiaries and cumulative case population. Research programs such as PREEMPT may validate use, but they should not be counted as commercial customers without procurement evidence.[CU001, CU002, CU003, CU011]

Customer segmentation table
SegmentBuyer / contracting entityUsers and payerUse caseScale / strategic valueEvidence gap
Hospital or health systemHealth or hospital system, potentially spanning multiple facility accountsCardiologists and radiologists order analyses; government and commercial payers influence reimbursementCCTA workflow with FFRCT and/or Plaque AnalysisA system can centralize procurement and support multi-account rolloutNamed contracts, system-level utilization, and revenue contribution are not disclosed
Individual hospital facilitySingle account defined as a facility ordering FFRCT, Plaque, or bothImaging physicians and referring cliniciansPer-analysis diagnostic supportIncluded in the more than 1,465 U.S. account base at 2025 year-endActive-case threshold and facility-level retention are not disclosed
Outpatient or office-based medical providerMedical provider accountPhysicians order analyses; reimbursement depends on payer policyAmbulatory CCTA interpretation and follow-on analysisExtends adoption beyond hospital settingsCurrent segment mix and realized pricing by setting are not in the assigned evidence
Existing FFRCT account expanding to PlaqueExisting provider or health-system customerAdditional ordering physicians and repeat usersPlaque quantification and staging on eligible CCTA scansCross-sell can increase analyses per installed accountPlaque attach rate and cohort revenue expansion are not disclosed
Clinical research programStudy sponsor or research consortium; commercial buyer not establishedInvestigators and participating sitesStandardized plaque analysis for study endpointsBuilds evidence and clinician familiarityResearch selection cannot be treated as recurring customer revenue

Segmentation uses Heartflow's account/customer definitions and billing disclosures. Research programs are separated from commercial customers, and no facility-level revenue is inferred.

[CU001, CU002, CU003, CU011]

6.2 Adoption trajectory without false comparability

The public adoption record is substantial but mixes different units. Heartflow reported more than 1,465 U.S. accounts as of December 31, 2025; an April 2026 complaint described relationships with more than 1,400 U.S. hospitals including 80% of the top 50 heart hospitals; and a July 2026 company release said adoption exceeded 1,800 institutions globally. Patient figures also moved from more than 650,000 in that July release to more than 750,000 in a September company job posting and the current homepage. These observations are not a same-population funnel: account, hospital, institution, and cumulative patient denominators differ, and company-issued figures are not independent customer confirmation. Quarterly revenue is therefore shown only as a commercial momentum indicator, not as a customer-count substitute.[CU001, CU006, CU007, CU008, CU009, CU012, CU013]

Customer growth / adoption trajectory table
MetricReported valuePeriod / dateAttributionConfidenceImplicationMissing denominator / limitation
U.S. installed accountsMore than 1,4652025-12-31Heartflow Form 10-KmediumLarge domestic base for utilization expansionAccount means facility, not unique health system or active monthly user
U.S. hospital relationshipsMore than 1,400; includes 80% of top 50 U.S. heart hospitals2026-04-13 filing dateHeartflow court complaintmediumCompany claims penetration among prominent institutionsHospital list, ranking basis, contract status, and utilization are not supplied
Global institutionsMore than 1,8002026-07-09Heartflow company release syndicated by NasdaqmediumIndicates international reachActive, paying, production, and pilot institutions are not separated
Cumulative patients managedMore than 650,0002026-07-09Heartflow company release syndicated by NasdaqmediumDemonstrates cumulative platform exposureUnique patients, repeat analyses, period flow, and product mix are not disclosed
Cumulative patientsMore than 750,0002026-09-25 posting; homepage checked 2026-10-04Heartflow job posting and official homepagemediumLater company-issued scale markerHomepage is undated and the metric is not independently audited in the assigned pool
Quarterly revenue$52.59 millionQ1 2026Seeking Alpha earnings summarymediumCommercial activity indicatorRevenue is not ARR, customer count, retention, or utilization
Quarterly revenue$64.1 million; up 48% year over yearQ2 2026TradingKey earnings-call summarymediumCommercial momentum acceleratedNo account count, same-customer growth, or retention denominator

Rows preserve the sources' account, hospital, institution, patient, and revenue labels. They are not summed or treated as comparable funnel stages; all customer-scale figures are company-issued except the two publisher-reported revenue summaries.

[CU001, CU006, CU007, CU008, CU009, CU012, CU013]

6.3 Usage expansion is visible; retention is not

Heartflow's commercial model can expand inside an installed account as referring physicians order more analyses and as Plaque is activated alongside FFRCT. TradingKey reported that the 340 accounts added in 2025 were ramping in line with management expectations, while new FFRCT accounts generally require about one year to approach mature utilization. The same report said Plaque remains below management's roughly 60% eligible-CCTA ceiling even as the year-end 2026 activation target increased to approximately 1,250 accounts. This is credible evidence of an expansion mechanism, not proof of retention: substantially all revenue was usage-driven, customer contracts were generally cancellable on 30 days' notice, and public NRR, GRR, churn, renewal, and cohort-level utilization data remain unavailable.[CU003, CU014, CU015, CU016]

FU001: Usage-led customer journey and expansion loop

The commercial journey moves from facility implementation to physician ordering and product expansion, with renewal durability obscured by cancellable contracts and missing cohort metrics.

Qualitative sequence derived from filings and current earnings summaries; it does not imply a disclosed conversion rate, standard contract duration, or uniform time-to-value beyond the management-reported FFRCT ramp.

[CU003, CU014, CU015, CU016]

6.4 Named proof and concentration remain the diligence bottlenecks

The assigned pool contains aggregate scale, clinical investigators, and research relationships, but no named paying hospital whose production deployment, contract status, utilization, and outcome are all public. A University of Kentucky HealthCare investigator is quoted about DECIDE, yet the release does not call the institution a Heartflow customer. PREEMPT establishes a research provider role, not hospital procurement. Concentration disclosure is similarly incomplete: Heartflow reported that no customer contributed 10% or more of revenue in 2023-2025, but warned that centralized decisions across multi-account health systems could cause disproportionate account loss. The sub-10% threshold therefore limits single-customer revenue concentration without resolving network-level procurement exposure.[CU004, CU005, CU010, CU011]

Named customer proof table
Named entity / groupSegmentPublicly evidenced roleProduction vs pilotOutcome evidenceCustomer-proof limitation
University of Kentucky HealthCare / Gill Heart & Vascular InstituteAcademic medical centerAffiliation of an investigator quoted about DECIDE findingsNot establishedInvestigator discusses risk reclassification in the studyThe release does not identify the institution as a customer, deployment site, or payer
PREEMPT study consortiumNIH-funded research programHeartflow selected as exclusive plaque provider for a 1,500-patient studyResearch use; commercial status not establishedStudy is intended to evaluate prevention strategiesProvider selection is not evidence of a paying hospital contract or renewal
Top 50 U.S. heart hospitalsSpecialist hospital groupHeartflow complaint claims relationships with 80% of the groupNot disclosed by institutionNo facility-level outcome is suppliedHospitals are unnamed and ranking basis, production status, utilization, and contract terms are absent

This is an evidence audit, not a customer-logo list. It intentionally records research affiliations and unnamed aggregate claims as limitations rather than upgrading them to named production deployments.

[CU009, CU010, CU011]

6.5 Exhibits

Chapter 07

07Risks

7.1 Legal, regulatory, and reimbursement exposure

The most immediate disclosed legal risk is active rather than hypothetical: Heartflow reported that it and certain employees received U.S. Department of Justice civil investigative demands in October 2025 concerning provider financial and contractual arrangements and sales and marketing activities under the Anti-Kickback Statute and False Claims Act. The company was cooperating but could not estimate duration or outcome, and said the result could materially affect the business, financial condition, results, or cash flows. Separately, Medicare and commercial payment remain recurring model dependencies. The 2025 Form 10-K explained that CMS resets rates using hospital cost and charge data and cited a July 2025 proposal for an up-to-15% reduction as a historical example; the fetched evidence does not establish that proposal's final outcome. A final enforcement action, exclusion risk, material repayment, or reimbursement reset that materially impairs account economics would be a thesis-break event.[CR001, CR002, CR003, CR004]

Regulatory / legal risk register
Risk or rulePublic statusLikelihood evidenceImpact evidenceDisclosed mitigationResidual exposureDiligence path or trigger
DOJ Anti-Kickback Statute / False Claims Act investigationCID received in October 2025; outcome and duration not estimable in the FY2025 Form 10-KActive investigation; no probability of an adverse outcome disclosedCompany says outcome may materially affect business, results, financial condition, or cash flowsCompany says it is cooperatingHigh uncertainty because no resolution, range of loss, or timetable is disclosedObtain counsel update; thesis breaks on material settlement, exclusion, complaint, or repayment exposure
Medicare OPPS and MPFS reimbursementRates reset through recurring rulemaking and hospital cost / charge inputsHistorical July 2025 proposal illustrates downside; final disposition is not established by the retained excerptLower payment can weaken provider economics and adoptionNo quantified mitigation maturity disclosed in retained evidenceAnnual rate and coding sensitivity remainsReconcile final 2026 rates and monitor proposed and final rules for 2027
FDA medical-device and AI lifecycle complianceCleared products remain subject to post-market controls; AI rules continue to evolveFiling discloses prior software defects and a subset of reports in FDA MAUDEErrors, recalls, delayed changes, or enforcement could impair adoption and reputationHuman-in-the-loop review and quality processes are disclosedNo public error-rate or correction-rate denominator in the assigned poolReview MAUDE records, recalls, CAPAs, complaint trends, and model-change controls
Health-data privacy and cybersecurityPlatform stores and transmits customer and patient identifying informationFiling says attacks are ongoing and complete prevention is virtually impossibleBreach can cause liability, downtime, lost certifications, customers, and remediation costEncryption and security certifications are described, but control effectiveness is not independently tested hereThird-party cloud and telecommunications providers expand the attack surfaceObtain current penetration tests, incident history, cyber coverage, and notification logs

Partial public register based on company-issued SEC filings plus independent SCCT guidance; qualitative rankings preserve disclosed uncertainty and do not estimate enforcement outcomes or incident probabilities.

[CR001, CR002, CR004, CR005, CR006, CR009, CR016]

7.2 Clinical input and execution quality

Heartflow's output depends on a chain that begins outside its own software. Independent SCCT guidance states that coronary CTA diagnostic quality depends on hardware, software, and acquisition protocols, while Heartflow's filing says inbound image limitations can affect its analyses. The same filing warns that AI models, analyst review, and software can contain undetected errors; it also discloses past code and release-process defects that intermittently interrupted physician use, with a subset reported through FDA MAUDE. These are not proof of current systematic inaccuracy, but they make image-acceptance rates, corrected-report rates, MAUDE trends, turnaround-time misses, and complaint closure times essential monitoring indicators. A sustained increase in clinically significant corrections or a recall would challenge confidence in the platform's risk-adjusted adoption case.[CR005, CR006, CR013, CR014]

Operational / quality / security risk register
Failure modeEvidence-based likelihood signalImpactMitigation maturityResidual exposureMonitor or kill criterion
Inadequate inbound CCTA image qualitySCCT identifies hardware, software, and acquisition-protocol dependence; company says limitations can affect analysisIncorrect or unavailable analysis and reduced physician confidenceStandards and image acceptance processes exist; performance data are not public in the poolCustomer-site acquisition remains partly outside Heartflow's controlMonitor rejection and rescan rates; break thesis on persistent site-level quality failures
AI, software, or analyst-review errorFiling discloses past defects and says undetected errors may remainMisdiagnosis exposure, interruption, recall, liability, and reputational damageHuman-in-the-loop inspection is disclosedError and corrected-report rates are not disclosedMonitor MAUDE, CAPA, recalls, corrections, and clinically significant error rates
AWS outage or terminationAll cloud infrastructure is outsourced to AWS; agreement permits 30-day terminationClinical service unavailability, delayed reports, and migration expenseAlternative services are described as obtainable, but tested failover is not disclosedSingle-provider operational concentrationObtain RTO / RPO and failover tests; break thesis on prolonged clinical outage without tested recovery
Security breach affecting patient or customer dataCompany says attacks are ongoing and full mitigation is virtually impossibleRegulatory liability, customer loss, downtime, and remediation costEncryption and certifications are company-disclosed controlsThird-party providers and sophisticated attackers remainMonitor reportable incidents, lost certifications, claims, and customer remediation
Support and complaint-handling bottleneckCurrent job material seeks leadership to scale support and investigate quality and accuracy complaintsSlower resolutions, weaker adoption, and compliance failuresDedicated leadership role and KPI mandate are describedStaffing level, backlog, first-contact resolution, and service levels are undisclosedObtain backlog and SLA trends; break thesis on sustained clinically material complaint delays

Qualitative risk assessment uses the FY2025 Form 10-K, SCCT guidance, and a company-issued job repost; likelihood labels are evidence signals rather than actuarial probabilities, and absent operating rates are explicit gaps.

[CR005, CR006, CR007, CR008, CR009, CR013]

7.3 Infrastructure, security, and counterparty concentration

Heartflow outsources all cloud infrastructure to AWS. Its filing says outages could make the clinical service inaccessible and that AWS can terminate on 30 days' notice, or sooner under specified conditions; the filing does not disclose an active multi-cloud failover. The platform also stores and transmits customer and patient identifying information, so a breach could combine downtime, liability, lost certifications, customer loss, and remediation expense. Customer concentration is subtler: no customer represented 10% or more of 2025 revenue, yet decision-making for multiple accounts can sit with a relatively small number of health systems. Company-issued hiring material shows that complaint investigation, quality and accuracy feedback, service levels, and support scaling require a dedicated cross-functional function. Recovery objectives, failover-test results, security incidents, health-system concentration, and support service-level performance remain non-public diligence items.[CR007, CR008, CR009, CR011, CR013, CR014]

Partner / dependency risk register
DependencyCounterpartyRoleConcentration evidenceFailure scenarioDisclosed mitigationResidual exposure
Cloud hostingAmazon Web ServicesEntire cloud-based infrastructureAll infrastructure outsourced to one providerOutage, security compromise, or termination interrupts report deliveryCompany expects similar services could be obtained elsewhereMigration time, tested failover, and recovery metrics are not disclosed
Health-system buying decisionsHospital systems and affiliated accountsOrder and utilization decisionsNo customer was at least 10% of 2025 revenue, but decision-making can span multiple accountsOne system reduces volumes or exits across several facilitiesCompany expects new customers to reduce concentrationSystem-level revenue, retention, and termination rights are undisclosed
Customer support capacitySpecialized support workforceComplaint investigation, service levels, training, and adoption supportCurrent leadership hiring indicates a need to scale with commercial growthBacklog or insufficient expertise delays clinical issue resolutionDedicated support leadership and KPI ownership are plannedNo public staffing, backlog, or service-level denominator
Supplier governanceDirect UK suppliers and other third partiesServices and operational inputsCompany says an April 2026 audit found no high-risk suppliersUndetected labor or third-party compliance issueProcurement review, questionnaires, audits, and supplier policiesCompany-issued audit conclusion does not independently verify all suppliers or cloud resilience

Dependency register uses company filings, company-issued recruiting material, and Heartflow's voluntary UK statement; supplier findings are management claims and do not establish absence of operational or compliance incidents.

[CR007, CR008, CR011, CR012, CR013, CR014]

7.4 Financial, governance, and market-risk implications

Product concentration and losses make execution setbacks more consequential. Heartflow FFRCT Analysis represented 98% of 2025 revenue, and the company reported a $116.8 million FY2025 net loss after a $92.4 million net loss for the first nine months; these are accounting losses, not cash burn or runway. The public website claims more than 750,000 patients treated and more than 1,800 institutions using Heartflow but gives no as-of date in the fetched page, so operating scale should not be mistaken for disclosed retention or service reliability. At the IPO, officers, directors, 5% holders, and affiliates were expected to own about 50.1% and exercise significant voting control; that is an IPO-date estimate, not a current ownership measure. MarketBeat reported a 2.73 beta on October 3, 2026, indicating public-market volatility in that data set. Investment monitoring should therefore distinguish accounting loss from cash use and require current ownership, cash-flow, product-mix, reliability, and retention evidence.[CR003, CR010, CR014, CR015, CR016]

FR001: Residual risk heatmap

Qualitative ranking places the active DOJ investigation, single-provider cloud dependency, and reimbursement / product concentration above governance and market-volatility risks, while preserving unknown probabilities.

Ordinal labels are analyst judgments anchored to disclosed status and impact, not estimated incident probabilities. Unknown likelihoods remain unknown, and the IPO ownership estimate is not treated as current ownership.

[CR002, CR003, CR006, CR007, CR010, CR015, CR016]

7.5 Exhibits

Chapter 08

08Valuation

8.1 Recommendation and Entry Discipline

The evidence supports a track/research-more recommendation rather than a price-insensitive buy. Heartflow reported $176.0 million of 2025 revenue, up 40%, followed by $52.6 million of first-quarter 2026 revenue, up 41%, and an 80.2% first-quarter gross margin. These are revenue and gross-margin measures, not ARR or proof of recurring retention. The same first-quarter release reported a $29.5 million net operating loss, including a $7.5 million non-cash impairment; that accounting loss is not cash burn. The 2025 filing separately reported $54.0 million of operating cash use and $280.2 million of year-end cash, equivalents, and investments. Those balances do not establish current cash or runway. Most importantly, no successful allocated source provides an October 2026 share price, net debt bridge, enterprise value, or transaction-ready entry multiple. Without those inputs, neither a target return nor a valuation range is supportable.[CV001, CV002, CV003, CV004, CV005, CV006, CV007, CV016]

Recommendation Summary
DimensionAssessmentEvidenceDecision implication
RecommendationTrack / research moreGrowth and margin are strong, but current price and EV are absentDo not issue a price-insensitive buy
ConfidenceMediumFiled 2025 financials and Q1 2026 company results; incomplete current market dataOperating facts are firmer than valuation
Risk ratingHighOperating loss, cash use, 98% FFRCT revenue concentration, and live litigationRequire downside and legal diligence before entry
Valuation stanceInsufficient evidenceNo October 2026 share price, net debt bridge, or comparable multiple setSet entry discipline only after current EV is verified

Revenue is not ARR; Q1 net operating loss is not cash burn; 2025 operating cash use is the cited cash-flow measure, and cash plus investments is not a runway estimate.

[CV001, CV002, CV003, CV004, CV005, CV006, CV010]
FV001: Recommendation Logic

The operating evidence narrows to a track/research-more decision because current valuation inputs are missing.

Node / ConnectionNode / fromToContext
Node 1 Growth [growth]2025 revenue +40%; Q1 2026 revenue +41%
Node 2 Gross margin [margin]Q1 2026 gross margin of 80.2%
Node 3 Cash discipline [cash]2025 operating cash use of $54.0M
Node 4 Concentration [concentration]FFRCT was 98% of 2025 revenue
Node 5 Valuation gap [valuation-gap]Current share price, EV, and peer multiples not established
Node 6 Decision [decision]Track / research more
Connection 1 Growth [growth]Gross margin [margin]
Connection 2 Gross margin [margin]Cash discipline [cash]
Connection 3 Cash discipline [cash]Concentration [concentration]
Connection 4 Concentration [concentration]Valuation gap [valuation-gap]
Connection 5 Valuation gap [valuation-gap]Decision [decision]

This is a qualitative decision chain; it does not encode a valuation multiple, return target, or scenario probability.

[CV001, CV002, CV003, CV005, CV010, CV012, CV016]

8.2 Thesis, Financing Context, and Downside

The thesis combines rapid case-driven revenue growth, high gross margin, and public-market access. Heartflow's August 2025 IPO sold 19,166,667 shares at $19.00 and generated about $332.4 million of net proceeds. At closing, $98.3 million of convertible notes converted into 6,470,743 common shares at $15.20, a 20% discount to the IPO price. That conversion is a historical dilution fact, not evidence of a continuing liquidation preference. Financing-history providers also conflict: Tracxn reports $936 million over 12 rounds, while Forge reports $890.7 million over 12 rounds and a $546.5 million April 2023 private post-money valuation. None is a current public valuation. The anti-thesis is operational concentration: FFRCT represented 98% of 2025 revenue. No individual customer contributed 10% or more, but Heartflow warned that decision-making across accounts can still be concentrated. Its April 2026 patent complaint against Cleerly adds a live legal and competitive dependency whose outcome is not established by the complaint.[CV008, CV009, CV010, CV011, CV012, CV013, CV014, CV015]

Thesis and Anti-Thesis
IssueThesis evidenceAnti-thesis evidenceWhat would change the view
Growth and economics2025 revenue grew 40%; Q1 2026 revenue grew 41% with 80.2% gross marginQ1 2026 net operating loss was $29.5M; 2025 operating cash use was $54.0MSustained growth with falling operating cash use
Product mixUsage-driven revenue has demonstrated scaleFFRCT represented 98% of 2025 revenueAudited product revenue and attach-rate diversification
Capital structureThe IPO generated about $332.4M of net proceeds$98.3M of notes converted at a 20% discount to the IPO priceCurrent fully diluted share count and net cash bridge
Customer and competitionNo single customer represented at least 10% of 2025 revenueDecision-making can still be concentrated; patent litigation with Cleerly is activeCustomer retention data and a verified litigation-status update

The table separates reported financial measures from analytical implications; the Cleerly complaint records Heartflow's allegations and does not establish liability or outcome.

[CV001, CV002, CV003, CV004, CV005, CV008, CV009, CV010, CV011, CV015]

8.3 Scenarios, Exit Readiness, and Final Diligence

The bull signal is execution against management's $228 million to $232 million 2026 revenue guidance while preserving roughly 80% gross margin and reducing operating cash use; even then, upside cannot be quantified without a current enterprise value. The base case is continued growth with persistent losses and FFRCT concentration, which supports monitoring rather than underwriting a precise return. The bear case is slower growth, gross-margin compression, rising operating cash use, failed product diversification, or an adverse litigation development. Heartflow is already publicly listed, so the relevant exit question is price and liquidity rather than IPO readiness. Final diligence should obtain current fully diluted shares, cash, investments, debt, share price, product-level revenue, retention, reimbursement realization, and peer transaction multiples on a common period and denominator. Thesis-break triggers are a material deceleration from disclosed growth, sustained margin deterioration, worsening cash use, continued near-total FFRCT dependence, or legal outcomes that impair commercialization. Until those checks are complete, scenario probabilities and dollar valuation ranges remain gaps rather than investable estimates.[CV002, CV003, CV005, CV007, CV010, CV015, CV016]

Bull, Base, and Bear Scenario Framework
ScenarioEvidence-based signalsValuation / return logicDownside triggerProbability signal
Bull2026 revenue reaches the $228M-$232M company-guided range, margin holds near Q1 levels, and cash use declinesRange not supportable until current EV and peer multiples are verifiedGrowth or margin misses while cash use fails to improveUnquantified; requires current trading and product-mix evidence
BaseRevenue grows but operating losses and FFRCT concentration persistTrack performance; do not infer return from historical private marksDiversification and retention remain undisclosedMost consistent with the available mixed evidence, but not assigned a numeric probability
BearGrowth slows, gross margin compresses, operating cash use rises, or legal exposure impairs executionDownside cannot be bounded without a current enterprise valueMaterial growth deceleration, worsening cash use, or adverse legal outcomeCredible downside path; magnitude and probability remain unquantified

Scenario values are deliberately not estimated because the assigned pool lacks a current share price, enterprise value, peer multiple set, and probability evidence.

[CV002, CV003, CV005, CV007, CV010, CV015]

8.4 Exhibits

Disclaimer

This report is produced by an AI-assisted research workflow for diligence purposes only and does not constitute investment advice. It is based on public information available as of 2026-10-04. Heartflow's public disclosures leave several underwriting-relevant items partially opaque, including plaque economics, retention, customer concentration, realized reimbursement economics, and current valuation inputs.

Evidence index

Claims
IDStatementConfidenceSources
CO001 Heartflow was incorporated in Delaware in 2007; its 2025 annual filing lists Mountain View as its principal executive-office location, while the Q1 2026 transcript disclosed an impairment associated with relocating headquarters to San Francisco. High SO001, SO003, SO006
CO002 Heartflow primarily earns usage-driven fees when physicians order FFRCT Analysis, Plaque Analysis, or both, and recognizes revenue when the requested analysis is delivered. High SO001, SO006
CO003 Heartflow began commercializing its platform in 2015. High SO001, SO006
CO004 Heartflow filed its S-1 on July 17, 2025, began Nasdaq trading under HTFL on August 8, 2025, and completed the IPO on August 11, 2025. High SO001, SO005, SO006, SO007
CO005 Heartflow reported $176.0 million of revenue and a $116.8 million net loss for the year ended December 31, 2025. Medium SO006
CO006 Heartflow management reported Q1 2026 revenue of $52.6 million, representing 41% year-over-year growth. Medium SO003
CO007 As of December 31, 2025, Heartflow reported more than 600,000 patients assessed, including 219,000 during 2025, and more than 1,465 U.S. accounts. Medium SO006
CO008 Heartflow's About page claims more than 750,000 patients treated and more than 1,800 institutions using Heartflow, without a publication date on the fetched page. Medium SO002
CO009 Heartflow employed 843 full-time employees globally as of December 31, 2025. Medium SO006
CO010 Current disclosures identify John Farquhar as president, CEO, and director, Vikram Verghese as CFO, William Weldon as board chair, and Charles Taylor as a founder and director. High SO001, SO002, SO003, SO006
CO011 Heartflow's 2025 annual filing reports approximately $332.4 million of net IPO proceeds and $115.1 million of principal repayment under its 2024 term loan during 2025. Medium SO006
CO012 Forge's narrative reports that HeartFlow raised $890.7 million across 12 funding rounds. Low SO005
CO013 Forge's structured profile instead lists $755.52 million of total funding and a $546.5 million April 2023 Series F post-money valuation, conflicting with its $890.7 million narrative total. Low SO005
CO014 In October 2025, Heartflow and certain employees received DOJ civil investigative demands concerning provider arrangements and sales and marketing activity under the Anti-Kickback Statute and False Claims Act. Medium SO006
CO015 An explicitly AI-generated Seeking Alpha item identifies clinician adoption pace, dependence on outcomes evidence, physician education, and back-half revenue weighting as Plaque growth risks. Low SO004
CO016 Barchart describes its opinion as a price-based composite of 13 technical studies, so the page is a market-timing signal rather than evidence of Heartflow's operating performance. Medium SO008
CM001 Heartflow's current serviceable market is paid analysis of CCTA for symptomatic CAD, while asymptomatic risk prediction remains an adjacency requiring further evidence, approval, coverage, and commercialization. Medium SM002, SM005, SM008
CM002 Company filings state that U.S. guidelines rate CCTA Class 1, Level A for certain chest-pain patients and Heartflow FFRCT Analysis Class 2a, Level B for treatment guidance. Medium SM002, SM005
CM003 Heartflow estimates that 9.5 million unique U.S. stable chest-pain patients receive non-invasive tests annually, using Clarivate ProcedureFinder as its starting denominator. Medium SM002
CM004 Heartflow estimates a $3.3 billion U.S. FFRCT opportunity from approximately 3.1 million eligible patients at a $1,067 U.S. average sales price. Medium SM002
CM005 Heartflow estimates an incremental $1.7 billion U.S. Plaque Analysis opportunity from approximately 5.5 million eligible patients at an estimated $300 U.S. sales price. Medium SM002
CM006 The approximately $5 billion combined U.S. opportunity is a Heartflow estimate that an independent market commentary repeats but does not independently reconstruct. Medium SM002, SM003
CM007 Heartflow reported that 195,000 U.S. patients analyzed in 2025 represented less than 2% of its overall market opportunity. Medium SM005, SM001
CM008 Heartflow reported that its 195,000 U.S. patients analyzed in 2025 represented approximately 19% of current U.S. CCTA volumes. Medium SM005
CM009 Heartflow reported more than 1,465 installed U.S. accounts as of December 31, 2025. Medium SM005
CM010 Heartflow's homepage displayed more than 1,800 institutions using the platform on October 4, 2026, without defining geographic scope or comparability with its filed account metric. Medium SM007
CM011 Heartflow reported FFRCT coverage policies representing approximately 99% of U.S. covered lives. Medium SM005
CM012 Heartflow reported Plaque Analysis coverage representing approximately 75% of U.S. covered lives after its Category I CPT code became effective January 1, 2026. Medium SM005
CM013 Heartflow's adoption motion is a direct enterprise sale spanning imaging physicians, referring cardiologists, interventionalists, administrators, IT, and payers, although no new capital equipment is required. Medium SM005, SM008
CM014 Heartflow primarily recognizes usage-driven fees when an account orders and receives FFRCT Analysis, Plaque Analysis, or both. Medium SM006
CM015 Heartflow says new accounts generally take 12 months to reach steady-state volume, defined as FFRCT utilization approaching 33% of CCTAs at the account. Medium SM006
CM016 Heartflow reported first-quarter 2026 revenue of $52.6 million, up 41% year over year, with the increase primarily attributed to higher U.S. FFRCT volume. Medium SM001
CP001 Heartflow's primary traditional competitors are non-invasive coronary testing modalities including SPECT, stress echocardiography, and PET. Medium SP003
CP002 Heartflow positions CCTA combined with its AI software against conventional diagnostic methods that produce false positive and false negative results. Medium SP001
CP003 Siemens Healthineers, GE Healthcare, Philips, and Canon manufacture imaging systems for stress tests and also manufacture the CT scanners used to acquire CCTAs. High SP003, SP006
CP004 Imaging hardware manufacturers hold structural distribution advantages and could integrate competing AI analysis software into their scanner suites. High SP003, SP006
CP005 Heartflow faces direct AI software competition from venture-backed companies including Cleerly, Inc., Elucid Bioimaging Inc., and Keya Medical Technology Co., Ltd. High SP003, SP004
CP006 Cleerly directly competes with Heartflow using AI-powered analysis of coronary CT scans with a specific emphasis on arterial plaque characterization and quantification. Medium SP006
CP007 Competitors commercially launched competing plaque analysis software prior to Heartflow Plaque Analysis, creating first-mover advantages and price pressure. High SP003, SP004
CP008 Heartflow expanded its platform into an end-to-end system spanning CCTA reading support, FFRCT, Plaque Analysis, risk staging, and PCI Navigator. Medium SP005
CP009 Heartflow had developed three software products with a fourth product, Heartflow PCI Planner, planned to launch in 2026 as an integrated feature. Medium SP004
CP010 Independent biomedical diligence identifies competitive pressure in cardiac imaging and analysis as a central watch item for differentiated SaMD solutions. Medium SP007
CP011 Heartflow supports customer workflow and software adoption through dedicated customer support teams assisting physicians and hospital staff. Medium SP002
CP012 The proposed 2026 CMS OPPS rule could result in a reduction of up to 15% in the Medicare reimbursement rate for the clinical APC that includes Heartflow FFRCT Analysis. Medium SP003
CP013 Heartflow's Plaque Analysis account count expanded from approximately 500 at the start of 2026 to more than 1,200 accounts by mid-2026. Medium SP005
CP014 Heartflow evaluates market expansion opportunities using structured data analysis and healthcare industry methodologies. Medium SP008
CI001 Heartflow delivered Q2 FY2026 total revenue of $64.1 million (+48% YoY), with U.S. revenue of $59.6 million (+51% YoY) including $7.8 million of plaque revenue, and global revenue cases reaching 84,491 (+74% YoY). Medium SI001
CI002 Management raised full-year 2026 revenue guidance to $246 million to $250 million (40% to 42% YoY growth), plaque revenue guidance to $29 million to $31 million, and plaque activated accounts to approximately 1,250. Medium SI001
CI003 Heartflow common stock last traded at $49.32 per share, representing an equity market capitalization of $4.29 billion based on 86.95 million shares outstanding as of October 2, 2026. Medium SI002, SI004, SI009
CI004 Heartflow achieved a second-quarter non-GAAP gross margin of 83.3% (+770 bps YoY) and raised full-year non-GAAP gross margin guidance to approximately 82%, targeting an 85% mid-term gross margin run-rate. Medium SI001
CI005 Second-quarter non-GAAP operating loss was $7.9 million compared to $11.5 million in the prior year, supported by non-GAAP SG&A of $37.8 million and R&D expenses of $23.5 million. Medium SI001
CI006 Heartflow concluded Q2 FY2026 with $246.8 million in cash, cash equivalents, and investments, with management affirming sufficient balance sheet liquidity to reach operational profitability. Medium SI001
CI007 Net cash used in operating activities stood at $54.0 million for full-year 2025, narrowing from $69.0 million in 2024 and $76.4 million in 2023, while total annual 2025 revenue reached $176.0 million. High SI004, SI005
CI008 Heartflow FFRCT shifted from Category III CPT coding to permanent Category I CPT code 75580 in January 2024, securing reimbursement coverage across 99.5% of insured U.S. lives. Medium SI008
CI009 Wall Street consensus estimates anticipated a Q2 FY2026 net loss of $-0.22 per share on projected revenues of $56.5 million to $57.0 million, representing an 85% year-over-year loss narrowing. Medium SI003
CI010 Heartflow has incurred cumulative net losses since inception including a net loss of $116.8 million in 2025, and historical revenue was generated almost entirely from sales of Heartflow FFRCT Analysis. High SI005, SI006
CI011 In October 2025, Heartflow received Civil Investigative Demands from the Department of Justice under the Anti-Kickback Statute and False Claims Act regarding provider arrangements and marketing. High SI005, SI006
CI012 Heartflow excludes ongoing intellectual property litigation defense costs from its non-GAAP SG&A operating expenses, citing multi-year patent disputes with competitors. Medium SI001
CI013 Heartflow does not publicly break out customer acquisition cost, hospital lifetime value, cohort net retention rates, or mature account plaque attach percentages in audited disclosures. Low
CI014 Forge's narrative reports that Heartflow raised $890.7 million across 12 funding rounds. Low SI010
CI015 Forge's structured snapshot lists $755.52 million of total funding, conflicting with its $890.7 million narrative total. Low SI010
CE001 Heartflow creates a personalized 3D model of coronary anatomy and simulates blood flow from standard CCTA images without requiring invasive catheterization. High SE001, SE005, SE010
CE002 Heartflow RoadMap Analysis provides anatomic visualization of coronary arteries and stenoses to assist physicians in focusing CCTA image review. High SE003, SE004, SE009
CE003 Heartflow FFRCT Analysis calculates blood flow and pinpoints hemodynamically significant stenosis with fractional flow reserve values of 0.80 or below across the major coronary arteries. High SE003, SE004, SE009
CE004 Heartflow Plaque Analysis provides quantitative assessment of coronary plaque volume and composition to inform individualized patient medical management. High SE003, SE004, SE009, SE010
CE005 Heartflow expects to commercially launch its fourth software product, Heartflow PCI Planner, in 2026 to guide procedural strategy and stent selection. High SE003, SE004
CE006 Heartflow's machine learning segmentation algorithms have been trained and refined on an image asset exceeding 160 million annotated CCTA images. Medium SE004
CE007 Hospital and imaging center clients securely transmit standard CCTA DICOM scans directly to Heartflow's cloud-based platform on Amazon Web Services. High SE004, SE007
CE008 Heartflow utilizes a human-in-the-loop production process where certified analysts inspect and edit automated anatomical segmentations using proprietary review software. Medium SE004
CE009 Heartflow's engineering stack utilizes Python, Django backend microservices, Vue.js frontend interfaces, and AWS distributed orchestration pipelines. Medium SE007, SE008
CE010 In the prospective NXT trial, Heartflow FFRCT demonstrated 86% per-vessel diagnostic accuracy compared to invasive FFR, significantly higher than 65% for CCTA alone. Medium SE004
CE011 The PRECISE trial demonstrated that the CCTA plus Heartflow FFRCT pathway achieved a 69% reduction in diagnostic-only catheterization and doubled therapeutic revascularization yield. Medium SE004
CE012 In the PACIFIC trial sub-study, Heartflow FFRCT achieved an Area Under the Curve of 0.94, outperforming PET at 0.87, CCTA at 0.83, and SPECT at 0.70. Medium SE004
CE013 As of December 31, 2025, Heartflow's intellectual property portfolio includes approximately 617 issued patents and 93 pending patent applications globally. Medium SE004
CE014 Heartflow maintains formal cybersecurity and quality certifications including HITRUST, ISO 27001, ISO 13485, SOC 2 Type 2, and UK CyberEssentials. Medium SE004
CE015 Heartflow has experienced software release defects reported under FDA MAUDE medical device reporting, though none have led to mandatory or voluntary product recalls. Medium SE004
CU001 Heartflow reported an installed base of more than 1,465 U.S. accounts as of December 31, 2025. Medium SU003
CU002 Heartflow defines an account as an individual facility ordering FFRCT Analysis, Plaque Analysis, or both, while a customer can be one account or a multi-account health or hospital system. Medium SU003
CU003 Heartflow sells to medical providers, generates substantially all revenue from usage-driven physician orders, and applies variable consideration tied to utilization and payer reimbursement rebates. Medium SU006
CU004 No single customer accounted for 10% or more of Heartflow revenue in 2023, 2024, or 2025. Medium SU003
CU005 Heartflow warned that decisions for multiple accounts can be concentrated in a small number of customers, so one customer loss could cause disproportionate account losses. Medium SU003
CU006 A July 2026 Heartflow release said the platform had been adopted by more than 1,800 institutions globally. Medium SU002
CU007 The same July 2026 Heartflow release said the company had managed care for more than 650,000 patients worldwide. Medium SU002
CU008 A September 2026 Heartflow job posting said the platform had been used for more than 750,000 patients worldwide, consistent with the undated homepage viewed on October 4, 2026. Medium SU001, SU007
CU009 In its April 2026 court complaint, Heartflow claimed relationships with more than 1,400 U.S. hospitals, including 80% of the top 50 U.S. heart hospitals. Medium SU004
CU010 A Heartflow release quotes a University of Kentucky HealthCare investigator about DECIDE findings but does not identify that institution as a Heartflow customer or deployment site. Medium SU002
CU011 TradingKey reported that Heartflow was selected as the exclusive plaque provider for the NIH-funded PREEMPT study involving 1,500 patients. Medium SU008
CU012 Seeking Alpha's Q1 2026 earnings summary reported Heartflow revenue of $52.59 million. Medium SU005
CU013 TradingKey reported Q2 2026 Heartflow revenue of $64.1 million, up 48% year over year. Medium SU008
CU014 TradingKey reported that the 340 accounts added during 2025 were ramping in line with management expectations and that newer FFRCT accounts generally require about one year to approach mature utilization. Medium SU008
CU015 TradingKey reported that Plaque utilization remained below management's approximately 60% eligible-CCTA estimate while the 2026 year-end activation target increased to about 1,250 accounts. Medium SU008
CU016 Heartflow disclosed that customer contracts typically include fixed consideration and are generally cancellable with 30 days' written notice. Medium SU006
CR001 The unresolved DOJ investigation creates unquantified legal and cash-flow risk because Heartflow says the outcome may materially affect business, results of operations, financial condition, or cash flows. Medium SR003
CR002 Heartflow said it could not estimate the DOJ investigation's duration or outcome and that the outcome may materially affect its business, results of operations, financial condition, or cash flows. Medium SR003
CR003 Heartflow FFRCT Analysis represented 98% of Heartflow's total revenue as of December 31, 2025. Medium SR003
CR004 Heartflow's 2025 Form 10-K says CMS reimbursement is reset using hospital cost and charge data and cites a July 2025 proposal for an up-to-15% reduction as a historical example, without establishing its final disposition in that passage. Medium SR003
CR005 Heartflow has an end-to-end CCTA input-quality dependency because its filing says image limitations can affect analysis and independent SCCT guidance says diagnostic image quality depends on hardware, software, and acquisition protocols. High SR001, SR003
CR006 Heartflow disclosed that its AI, software, and analyst-review processes may not identify all errors and that past code and release-process defects intermittently interrupted physicians' ability to use the platform. Medium SR003
CR007 Heartflow says it outsources all cloud-based infrastructure to Amazon Web Services. Medium SR003
CR008 Heartflow's AWS agreement permits termination on 30 days' advance notice and allows earlier termination under specified suspension, third-party technology, legal, or uncured-breach conditions. Medium SR003
CR009 Heartflow's filing says a breach affecting customer or patient information could cause system disruption, liability, financial harm, lost security certifications, customer loss, and remediation cost. Medium SR003
CR010 Heartflow reported a $116.8 million FY2025 accounting net loss after reporting a $92.4 million accounting net loss for the first nine months of 2025. High SR003, SR007
CR011 No single customer accounted for at least 10% of Heartflow's 2025 revenue, but the company says decision-making for multiple accounts can be concentrated in a relatively small number of customers. Medium SR003
CR012 Heartflow says its April 2026 supplier audit found no high-risk suppliers, a company-issued conclusion that does not independently establish the absence of supplier incidents. Medium SR004
CR013 A company-issued Director of Customer Support job repost assigns the role responsibility for product quality and accuracy complaint investigations, support scaling, service levels, and customer-support metrics. Medium SR005
CR014 Heartflow's homepage claims more than 750,000 patients treated and more than 1,800 institutions using Heartflow, without an as-of date in the fetched page. Medium SR008
CR015 MarketBeat reported a 2.73 beta for Heartflow in an October 3, 2026 article. Medium SR006
CR016 Heartflow's IPO prospectus estimated that officers, directors, 5% holders, and affiliates would own approximately 50.1% after the offering and could exercise significant control over stockholder decisions. Medium SR002
CV001 Heartflow reported $176.0 million of revenue for 2025, 40% above 2024. Medium SV005
CV002 Heartflow reported $52.6 million of revenue for Q1 2026, 41% above the prior-year quarter. Medium SV003
CV003 Heartflow reported an 80.2% gross margin for Q1 2026. Medium SV003
CV004 Heartflow reported a $29.5 million net operating loss for Q1 2026, including a $7.5 million non-cash impairment charge. Medium SV003
CV005 Heartflow used $54.0 million of cash in operating activities during 2025. Medium SV005
CV006 Heartflow held $280.2 million of cash, cash equivalents, and investments at December 31, 2025. Medium SV005
CV007 In May 2026, Heartflow guided to $228 million to $232 million of total 2026 revenue. Medium SV003
CV008 Heartflow's August 2025 IPO sold 19,166,667 shares at $19.00 and generated approximately $332.4 million of net proceeds. Medium SV005, SV006
CV009 At the IPO, $98.3 million of convertible notes converted into 6,470,743 common shares at $15.20 per share, a 20% discount to the IPO price. Medium SV005, SV006
CV010 Heartflow FFRCT Analysis represented 98% of Heartflow's total revenue in 2025. Medium SV005
CV011 No single customer represented at least 10% of 2025 revenue, although Heartflow disclosed that decision-making across some accounts is concentrated among relatively few customers. Medium SV005
CV012 Forge reports a $546.5 million post-money valuation for Heartflow's April 2023 Series F financing. Medium SV004
CV013 Tracxn reports that Heartflow raised $936 million over 12 funding rounds. Medium SV001
CV014 Forge reports $890.7 million of Heartflow funding over 12 rounds, conflicting with Tracxn's $936 million total. Medium SV004
CV015 Heartflow filed a patent-infringement complaint against Cleerly in April 2026. Medium SV002
CV016 The assigned evidence does not establish a current 2026 stock price, enterprise value, comparable multiple set, or probability-weighted valuation range, so a price-sensitive buy recommendation is not supportable. Medium SV004, SV005, SV006, SV007, SV008
Sources
IDPublisherTitleQuote
SO001 Heartflow, Inc. Heartflow, Inc. Form S-1 We primarily generate revenue on a “pay-per-click” basis each time a physician chooses to review either our Heartflow FFRCT Analysis, Heartflow Plaque Analysis, or both.
SO002 Heartflow, Inc. Rewriting the Story of Coronary Artery Disease >750K Patients Treated >1,800 Institutions Using Heartflow and Growing
SO003 Investing.com Earnings call transcript: HeartFlow Q1 2026 beats EPS forecast In the first quarter of 2026, revenue was $52.6 million, up 41% year-over-year on 67% global case growth.
SO004 Seeking Alpha HeartFlow targets $218M-$222M in 2026 revenue and accelerates PCI Navigator launch while expanding plaque coverage Key risks are clinician adoption pace, dependence on clinical outcomes data, the need for physician education, and revenue being weighted toward the back half of the year.
SO005 Forge Global HeartFlow IPO Timeline and Financing Details Per Forge data, HeartFlow has raised a total of $890.7 million in funding over 12 rounds.
SO006 Heartflow, Inc. Heartflow, Inc. 2025 Form 10-K In October 2025, the Company and certain of its employees received civil investigative demands (the “CID”) from the U.S. Department of Justice, Civil Division, in connection with an investigation under the federal Anti-Kickback Statute and Civil False Claims Act (the “Investigation”).
SO007 Tickeron HeartFlow (HTFL) Shares Rise +54.4% in 30 Days Following Strong Q2 Results and Guidance Increase HeartFlow shares rose about 54.4% in the 30 days through the August 14, 2026 close
SO008 Barchart HTFL Barchart Opinion for Heartflow Stock Each Opinion requires six months' worth of trading activity and run the prices through 13 different technical indicators.
SM001 Seeking Alpha HeartFlow: A Premium AI Diagnostics Story (NASDAQ:HTFL) With only ~2% market penetration, 41% y/y revenue growth, and justified premium valuation, HTFL offers an attractive long-term growth runway despite execution and concentration risks.
SM002 Heartflow, Inc. Heartflow, Inc. prospectus (Form 424B4) We estimate our current market opportunity in the United States for our Heartflow FFRCT Analysis and Heartflow Plaque Analysis is approximately $5 billion.
SM003 Tickeron HeartFlow (HTFL) Shares Rise +54.4% in 30 Days Following Strong Q2 Results and Guidance Increase HeartFlow went public on Nasdaq in August 2025 and is followed by investors as an AI-enabled diagnostics name with a U.S. market opportunity it estimates at about $5 billion for its FFRCT and Plaque products.
SM005 Heartflow, Inc. Annual Report on Form 10-K for the year ended December 31, 2025 While we have achieved significant commercial adoption to date, including 195,000 patients on our Heartflow Platform in the U.S. in 2025 alone, we believe this represented less than 2% of our overall market opportunity and approximately 19% of current U.S. CCTA volumes.
SM006 Heartflow, Inc. Quarterly Report on Form 10-Q for the quarter ended September 30, 2025 New accounts generally take 12 months to reach steady state revenue case volumes. We consider steady state case volumes to be attained once the account reaches FFR CT utilization rates approaching 33% of CCTAs occurring at the account—a level that is generally sustained over time based on historical trends.
SM007 Heartflow, Inc. Heartflow - Decisive Coronary Care >1,800 Institutions Using Heartflow and Growing
SM008 Umbrex Heartflow Strategy and Business Model Hospital systems and integrated delivery networks: These are often the most important economic customers because they control imaging infrastructure, care pathways, and contracting.
SM009 SimplyWallSt HeartFlow (Nasdaq:HTFL) - Stock Analysis
SP001 Heartflow Heartflow - Decisive Coronary Care Conventional diagnostic methods frequently provide misleading information that can result in undiagnosed disease, unnecessary procedures, incorrect treatment plans, poor patient experience, and increased cost to healthcare systems.
SP002 Welcome to the Jungle Director of Customer Support – HeartFlow – Permanent contract in Austin This role will lead a team to deliver world-class support to Heartflow’s customers, including physicians and hospital staff using our revolutionary SaaS technology to manage their patients.
SP003 Securities and Exchange Commission Form 10-K for Heartflow, Inc. for the Fiscal Year Ended December 31, 2025 We consider our primary competition to be traditional non-invasive tests for CAD including primarily stress tests such as SPECT, stress echocardiography and PET.
SP004 Heartflow Investor Relations Form 10-Q for Heartflow INC filed 11/12/2025 Some of these competitors commercially launched competing plaque analysis products prior to our launch of Heartflow Plaque Analysis and may have a first-mover advantage as a result.
SP005 Investing.com HeartFlow at Wells Fargo conference: plaque analysis drives growth By Investing.com HeartFlow described its platform as an end-to-end system for coronary artery disease care. It includes CCTA reading support, separately reimbursed FFRCT and Plaque Analysis products, a staging platform for risk management and the new HeartFlow PCI Navigator tool.
SP006 KoalaGains HeartFlow, Inc. (HTFL) Competitive Analysis & Comparison | KoalaGains Cleerly is a private, venture-backed company and a direct competitor to HeartFlow, making this a peer-to-peer comparison of innovators. Like HeartFlow, Cleerly uses AI-powered analysis of coronary CT scans to provide advanced cardiac diagnostics.
SP007 Vantage Biomed Sample Evaluation — HeartFlow Competitive pressure in cardiac imaging and analysis is a central watch item for a differentiated SaMD entering established diagnostic workflows.
SP008 Dataford Heartflow Business Analyst Interview Questions & Guide 2026 Explain how you would approach analyzing a new market opportunity for Heartflow.
SP009 Zippia HeartFlow Mountain View, CA Jobs
SI001 Yahoo Finance Heartflow, Inc. (HTFL) Q2 FY2026 earnings call transcript Total revenue for the second quarter was $64.1 million, up 48%. U.S. revenue grew 51% to $59.6 million, including $7.8 million of plaque revenue. OUS and other revenue increased to $4.5 million. Total global revenue cases for the quarter reached 84,491, up 74%.
SI002 WallStreetZen How to Buy Heartflow Stock: Invest in HTFL Shares Today (Sep 19, 2026) As of Oct 2, 2026, there are 86.95M HTFL shares outstanding. The market cap of HTFL is $4.29B. In the last 24 hours, 1.64M HTFL shares were traded.
SI003 Barchart HeartFlow's Path to Profitability Looks Clearer Than Before, If Revenue Acceleration Holds Analysts expect HTFL to report a loss of **$-0.22 per share** for Q2 2026, with revenue estimates ranging from $56.47M to $57M according to consensus forecasts. The company most recently reported Q1 2026 earnings of **$-0.23 per share**. Compared to the same quarter last year when HTFL posted a loss of **$-1.46 per share**, the consensus estimate represents an **84.93% improvement** year-over-year
SI004 Perplexity Finance Heartflow, Inc. Common Stock Stock Price - Perplexity Investor interest has been supported by a Brown Capital Management Small Company Fund letter highlighting its high-margin expansion potential, with 2025 revenue of $176M (+40%) and an improving EBIT margin.
SI005 Securities and Exchange Commission Heartflow, Inc. Form 10-K Annual Report for the fiscal year ended December 31, 2025 We have incurred significant net losses since our inception, we expect to incur additional substantial losses in the foreseeable future and we may not be able to achieve or sustain profitability. ... Our revenue is currently generated almost entirely from the sales of only one product, Heartflow FFRCT Analysis
SI006 Securities and Exchange Commission Form 10-Q for Heartflow INC filed 11/12/2025 In October 2025, the Company and certain of its employees received civil investigative demands (the “CID”) from the U.S. Department of Justice, Civil Division, in connection with an investigation under the federal Anti-Kickback Statute and Civil False Claims Act (the “Investigation”). The CID requests information, documents, and testimony focused on the Company’s financial and contractual arrangements with providers and its sales and marketing activities.
SI008 Buying Your Time Heartflow Deep Dive ($HTFL) - Part 1 That changed decisively in January 2024 when FFRct moved from temporary Category III coding to a permanent Category I CPT code. ... Private payers followed Medicare’s lead, and HeartFlow now reports coverage for FFRCT across 99.5% of insured U.S. lives.
SI009 MarketBeat Heartflow Stock Bumped Up to Buy by Wall Street Zen Shares of HTFL stock opened at $49.32 on Friday. Heartflow has a 52-week low of $20.13 and a 52-week high of $52.22. The stock has a market cap of $4.29 billion, a PE ratio of -26.95 and a beta of 2.73.
SI010 Forge Global HeartFlow IPO Timeline and Financing Details Per Forge data, HeartFlow has raised a total of $890.7 million in funding over 12 rounds. ... Total Funding $755.52M
SE001 Heartflow, Inc. Heartflow - Decisive Coronary Care With Heartflow, a CCTA scan is transformed into a dynamic and personalized 3D model of the heart, assessing anatomy and physiology.
SE003 Heartflow, Inc. Form 10-Q for Heartflow INC filed 11/12/2025 To date, we have developed three software products (with a fourth product expected to launch in 2026) under the Heartflow Platform that provide physicians with the critical insights needed to effectively diagnose and manage CAD
SE004 U.S. Securities and Exchange Commission Heartflow, Inc. Annual Report Form 10-K for Fiscal Year Ended December 31, 2025 When the images arrive, we leverage multiple machine learning algorithms which have been trained from a database of millions of annotated CCTA images to precisely segment CCTA data and extract patient-specific 3D anatomy, which includes the coronary tree, myocardium and other anatomic features.
SE005 National Science Foundation HeartFlow's AI-powered medical technology debuts on Nasdaq | NSF From standard coronary CT angiography (CCTA) images, FFRCT analysis generated a 3D model, or digital twin, of a patient's heart and simulated blood flow through it, revealing pressure differences in the arteries.
SE007 VueJobs Senior Software Engineer at Heartflow Independent, end-to-end ownership of the design, development, testing, and maintenance of robust APIs (Python, AWS), interactive web applications (Django backend and Vue.js frontend), pipeline orchestrations, and associated infrastructure.
SE008 Teal Media Software Engineer – Frontend @ Heartflow cleared for use in the US, UK, Europe, Japan and Canada, and has been used for more than 750,000 patients worldwide.
SE009 Heartflow (reposted by Teal) Principal Device Quality Engineer at Heartflow Heartflow is the first AI-driven non-invasive integrated heart care solution across the CCTA pathway that helps clinicians identify stenoses in the coronary arteries (RoadMap™Analysis), assess coronary blood flow (FFR CT Analysis), and characterize and quantify coronary atherosclerosis (Plaque Analysis).
SE010 Heartflow, Inc. Heartflow Brand Guidelines Our AI-driven platform creates a 3D model of the heart, providing physicians with precise, personalized insights
SU001 Heartflow (reposted by Blue Venture Fund Job Board) IT Director, Salesforce Platform Owner @ HeartFlow Heartflow is a publicly traded company (HTFL) that has received international recognition for exceptional strides in healthcare innovation, is supported by medical societies around the world, cleared for use in the US, UK, Europe, Japan and Canada, and has been used for more than 750,000 patients worldwide.
SU002 Heartflow (syndicated by GlobeNewswire and Nasdaq) New Data at SCCT 2026 Reinforce Heartflow Plaque Analysis as the Standard for AI-Powered Coronary Artery Disease Management Heartflow has been adopted by more than 1,800 institutions globally and continues to strengthen its commercial presence to make this cutting-edge solution more widely available to an increasingly diverse patient population.
SU003 Heartflow, Inc. (filed with the U.S. Securities and Exchange Commission) Annual Report on Form 10-K for the Fiscal Year Ended December 31, 2025 While a single customer may include multiple accounts, no single customer accounted for 10% or more of our revenue during the years ended December 31, 2025, 2024 and 2023. However, the decision-making function for some of these accounts is concentrated in a relatively small number of customers, such that the loss of one customer could result in a disproportionate loss across our accounts.
SU004 Heartflow, Inc. (court complaint) Heartflow, Inc. v. Cleerly, Inc. Complaint for Patent Infringement Heartflow’s products have been used at over 1,500 hospitals in the United States to diagnose heart disease in over 600,000 patients.
SU005 Seeking Alpha HeartFlow, Inc. (HTFL) Q1 2026 Earnings Call Transcript Revenue of $52.59M beats by $2.88M
SU006 Heartflow, Inc. Quarterly Report on Form 10-Q for the Quarter Ended September 30, 2025 The Company recognizes usage-driven fee revenue upon delivery of the requested analysis to the physician, which is when control of these services is transferred to the customer. The Company recognizes revenue on a straight-line basis over the contract term for subscriptions where the customer pays a fixed amount upfront for unlimited analyses. Contracts with customers typically include a fixed amount of consideration and are generally cancellable with 30 days ’ written notice.
SU007 Heartflow Heartflow - Decisive Coronary Care
SU008 TradingKey HeartFlow (HTFL) Q2 2026 Earnings Call: Revenue Up 48%, Guidance Raised Plaque growth was supported by new account activations, more ordering physicians and increasing repeat use. Management raised its target for Plaque-activated accounts to approximately 1,250 by year-end and said coverage had reached about 78%.
SU009 Xtalks Heartflow Closes $364M IPO for AI-Driven Cardiac Imaging
SR001 Society of Cardiovascular Computed Tomography SCCT Guidelines for the Performance and Acquisition of Coronary Computed Tomographic Angiography It is generally accepted that the diagnostic quality of coronary physician or physician assistant. If pediatric imaging is performed, CTA images is highly dependent on a number of technical factors, at least one person certified in pediatric advanced life support including hardware, software, and acquisition protocols. These (PALS) should be available during the scan, and pediatric specific factors still continue to evolve at a rapid pace, resulting in the “state
SR002 Heartflow, Inc. (prospectus hosted by Stifel) HeartFlow, Inc. Form 424B4 prospectus Upon completion of this offering, our executive officers, directors, owners of 5% or more of our capital stock and their respective affiliates will own, in the aggregate, approximately 50.1% o f our common stock (assuming no exercise of the underwriters’ option to purchase additional shares and no purchases of shares in this offering by anyone in this group).
SR003 Heartflow, Inc. (filed with the SEC) Heartflow, Inc. Form 10-K for the fiscal year ended December 31, 2025 In October 2025, we and certain of our employees received civil investigative demands (the “CID”) from the U.S. Department of Justice, Civil Division, in connection with an investigation under the federal Anti-Kickback Statute and Civil False Claims Act (the “Investigation”).
SR004 Heartflow UK Modern Slavery Statement for 2026 We assess and mitigate such risk through annual audits, with our most recent audit in April 2026 concluding that no suppliers were found to be high risk.
SR005 Heartflow (job reposted by Welcome to the Jungle) Director of Customer Support - HeartFlow This role will lead a team to deliver world-class support to Heartflow’s customers, including physicians and hospital staff using our revolutionary SaaS technology to manage their patients.
SR006 MarketBeat Heartflow Stock Bumped Up to Buy by Wall Street Zen The stock has a market cap of $4.29 billion, a PE ratio of -26.95 and a beta of 2.73.
SR007 Heartflow, Inc. Form 10-Q for the quarter ended September 30, 2025 For the three and nine months ended September 30, 2025, we incurred net losses of $50.9 million and $92.4 million, respectively.
SR008 Heartflow Heartflow - Decisive Coronary Care >750K Patients Treated >1,800 Institutions Using Heartflow and Growing
SV001 Tracxn 2026 Funding Rounds & List of Investors - HeartFlow HeartFlow has raised ... a total of $936M ... over ... 12 funding rounds
SV002 Heartflow, Inc. Complaint for Patent Infringement: Heartflow, Inc. v. Cleerly, Inc. This is an action for patent infringement by Heartflow
SV003 Heartflow, Inc. via GlobeNewswire Heartflow Reports First Quarter 2026 Financial Results and Raises Full Year 2026 Guidance Total revenue of $52.6 million, a 41% increase year-over-year ... Gross margin of 80.2% ... Net operating loss of $29.5 million, including a $7.5 million non-cash impairment charge
SV004 Forge Global HeartFlow IPO Timeline and Financing Details - Forge Per Forge data, HeartFlow has raised a total of $890.7 million in funding over 12 rounds.
SV005 Heartflow, Inc. Form 10-K Annual Report for the Fiscal Year Ended December 31, 2025 We recognized revenue of $176.0 million for the year ended December 31, 2025 ... Heartflow FFRCT Analysis has served as our commercial foundation, representing 98% of our total revenue as of December 31, 2025.
SV006 Heartflow, Inc. Form 10-Q for the Quarterly Period Ended September 30, 2025 On August 11, 2025, the Company completed its IPO of 19,166,667 shares of its common stock ... at a price to the public of $19.00 per share.
SV007 PM Insights HeartFlow Valuation HeartFlow Valuation and Overview ... HeartFlow Funding Rounds & Cap Table Details
SV008 Silicon Valley Investclub Heartflow Raises $316.7 Million in IPO at a $2.27 Billion Valuation
SV009 Life Science Market Research Medtech Startups: HeartFlow, PathoGene, Farapulse, & more